A5061444969- Bipolar Disorder and Treatment
- Neurotransmitter Receptor Influence on Behavior
- Neuroendocrine regulation and behavior
- Circadian rhythm and melatonin
- Stress Responses and Cortisol
- Neuroscience and Neuropharmacology Research
- Tryptophan and brain disorders
- Sleep and related disorders
- Ion channel regulation and function
- COVID-19 and Mental Health
- Dietary Effects on Health
- Genetics and Neurodevelopmental Disorders
- Autism Spectrum Disorder Research
- Memory and Neural Mechanisms
- Cannabis and Cannabinoid Research
- Psychological and Temporal Perspectives Research
- Sleep and Wakefulness Research
- Mental Health Research Topics
- Schizophrenia research and treatment
- Suicide and Self-Harm Studies
- Adipose Tissue and Metabolism
- Psychological Well-being and Life Satisfaction
- Diet, Metabolism, and Disease
- Obsessive-Compulsive Spectrum Disorders
- Biochemical effects in animals
Academic College of Tel Aviv-Yafo
2015-2024
Aristotle University of Thessaloniki
2023-2024
Qatar University
2021
Tel Aviv University
1997-2021
Ben-Gurion University of the Negev
2000-2019
University of Minnesota
2005-2019
University of Minnesota, Duluth
2006-2018
Tata Institute of Fundamental Research
2015
Geha Mental Health Center
2015
University of Minnesota System
2013
The neurobiological underpinnings of mood modulation, molecular pathophysiology manic-depressive illness, and therapeutic mechanism stabilizers are largely unknown. extracellular signal-regulated kinase (ERK) pathway is activated by neurotrophins other neuroactive chemicals to produce their effects on neuronal differentiation, survival, regeneration, structural functional plasticity. We found that lithium valproate, commonly used for the treatment stimulated ERK in rat hippocampus frontal...
The mechanism by which lithium exerts either its anti-manic or antidepressant effects remains to be fully elucidated. Although inhibits the enzyme glycogen synthase kinase-3 (GSK-3) at concentrations that are relevant for treatment of bipolar disorder, it is unclear whether GSK-3-related mechanisms responsible therapeutic in this disease. We report AR-A014418 (a selective GSK-3 inhibitor) induces behavioural changes consistent with medications. Subacute intraperitoneal injections reduced...
Increasing data suggest that impairments of cellular plasticity underlie the pathophysiology bipolar disorder. In this context, it is noteworthy AMPA glutamate receptor trafficking regulates synaptic plasticity, effects mediated by signaling cascades, which are targets for antimanic agents. The present studies were undertaken to determine whether two clinically effective, but structurally highly dissimilar, agents lithium and valproate regulate expression subunit 1 (GluR1). Chronic (but not...
In the context of bipolar disorder (BPD) research it was demonstrated that administration structurally dissimilar mood stabilizers lithium and valproate produced a striking reduction in protein kinase C (PKC) rat brain. small clinical study, tamoxifen (a PKC inhibitor) had antimanic efficacy. However, both exert many biochemical changes attribution therapeutic relevance to any molecular findings needs be based on linking them behavioral effects.The present study designed explore such...
Abstract Background To compare the predictive value of circadian syndrome (CircS) and Metabolic (MetS) for cardiovascular disease. Method We used data 9360 Chinese adults aged ≥40 years from 2011 China Health Retirement Longitudinal Study (CHARLS). Of participants, 8253 people were followed in 2015 survey. MetS was defined using harmonized criteria. CircS based on components International Diabetes Federation (IDF) plus short sleep depression. The cut‐off set as ≥4. Multivariable logistic...
Circadian rhythms are considered an important factor in the aetiology, expression and treatment of major affective disorders, including seasonal disorder (SAD). However, data on effects daylight length manipulation or melatonin administration complex. It has been suggested that since diurnal nocturnal mammals differ significantly their physiological behavioural responses to daylight, rodents offer a preferable model disorders related circadian human. We previously found fat sand rats...
The study aimed to compare the predictive value of Circadian Syndrome (CircS) and Metabolic (MetS) for cardiovascular disease (CVD). We used data 12,156 adults aged ≥20 years who attended National Health Nutrition Examination Survey (NHANES) 2005-2016. Mortality was obtained from registry updated 2019. CircS defined based on components MetS, in addition short sleep depression. Both MetS were directly associated with self-reported history CVD. odds ratios prevalent CVD respectively, 2.92 (95%...
Circadian syndrome (CircS) is considered a better predictor for cardiovascular disease than the metabolic (MetS). We aim to examine associations between CircS and MetS with cognition in Chinese adults.