A5037853531- Treatment of Major Depression
- Tryptophan and brain disorders
- Neuroscience and Neuropharmacology Research
- Stress Responses and Cortisol
- Bipolar Disorder and Treatment
- Neurotransmitter Receptor Influence on Behavior
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Neuroendocrine regulation and behavior
- Receptor Mechanisms and Signaling
- Genetics and Neurodevelopmental Disorders
- Wnt/β-catenin signaling in development and cancer
- Anesthesia and Neurotoxicity Research
- Nuclear Receptors and Signaling
- Mental Health Research Topics
- Epigenetics and DNA Methylation
- Cancer-related gene regulation
- Ion channel regulation and function
- Computational Drug Discovery Methods
- Functional Brain Connectivity Studies
- Estrogen and related hormone effects
- Memory and Neural Mechanisms
- Diet and metabolism studies
- Genetic Neurodegenerative Diseases
- Phosphodiesterase function and regulation
University of Maryland, Baltimore
2016-2025
VA Maryland Health Care System
2014-2025
University of Mary
2025
National Institutes of Health
2004-2024
Institute on Aging
2016-2024
National Institute on Aging
2016-2024
National Institute of Mental Health
2004-2021
National Center for Advancing Translational Sciences
2018-2021
University of Baltimore
2009-2016
Notre Dame of Maryland University
2016
The neurobiological underpinnings of mood modulation, molecular pathophysiology manic-depressive illness, and therapeutic mechanism stabilizers are largely unknown. extracellular signal-regulated kinase (ERK) pathway is activated by neurotrophins other neuroactive chemicals to produce their effects on neuronal differentiation, survival, regeneration, structural functional plasticity. We found that lithium valproate, commonly used for the treatment stimulated ERK in rat hippocampus frontal...
The forced swim test is a rodent behavioral used for evaluation of antidepressant drugs, efficacy new compounds, and experimental manipulations that are aimed at rendering or preventing depressive-like states. Mice placed in an inescapable transparent tank filled with water their escape related mobility behavior measured. straightforward to conduct reliably it requires minimal specialized equipment. Successful implementation the adherence certain procedural details minimization unwarranted...
The tail-suspension test is a mouse behavioral useful in the screening of potential antidepressant drugs, and assessing other manipulations that are expected to affect depression related behaviors. Mice suspended by their tails with tape, such position it cannot escape or hold on nearby surfaces. During this test, typically six minutes duration, resulting oriented behaviors quantified. valuable tool drug discovery for high-throughput prospective compounds. Here, we describe details required...
Manic-depressive illness has been conceptualized as a neurochemical illness. However, brain imaging and postmortem studies reveal gray-matter reductions, well neuronal glial atrophy loss in discrete regions of manic-depressive patients. The roles such cerebral morphological deficits the neuropathophysiology therapeutic mechanisms are unknown. Valproate (2-propylpentanoate) is commonly used mood stabilizer. ERK (extracellular signal-regulated kinase) pathway by neurotrophic factors to...
Ketamine is a well-characterized NMDA receptor (NMDAR) antagonist, although the relevance of this pharmacology to its rapid (within hours administration) antidepressant actions, which depend on mechanisms convergent with strengthening excitatory synapses, unclear. Activation synaptic NMDARs necessary for induction canonical long-term potentiation (LTP) leading sustained expression increased strength. We tested hypothesis that effects requires NMDAR activation, by using behavioral...
The mechanism by which lithium exerts either its anti-manic or antidepressant effects remains to be fully elucidated. Although inhibits the enzyme glycogen synthase kinase-3 (GSK-3) at concentrations that are relevant for treatment of bipolar disorder, it is unclear whether GSK-3-related mechanisms responsible therapeutic in this disease. We report AR-A014418 (a selective GSK-3 inhibitor) induces behavioural changes consistent with medications. Subacute intraperitoneal injections reduced...