A5010884266- Advanced Drug Delivery Systems
- Pharmacological Effects and Toxicity Studies
- Hydrogels: synthesis, properties, applications
- biodegradable polymer synthesis and properties
- Supramolecular Self-Assembly in Materials
- Lipid Membrane Structure and Behavior
- Cannabis and Cannabinoid Research
- Analytical Chemistry and Chromatography
- Molecular spectroscopy and chirality
Bar-Ilan University
2020-2022
Abstract Background Nanoparticles (NPs) incorporating drug formulations can be used to facilitate passage through biological barriers including the blood–brain barrier (BBB) and increase delivery bioavailability. Hence, NP-based administration may enhance efficiency of current antipsychotics. Encapsulation within NPs resolve aqueous solubility problems that not only reduce permeability BBB but also affect targeting. The present study describes a new system based on proteinoid explore...
Risperidone (RSP) is an atypical antipsychotic drug widely used to treat schizophrenia and bipolar disorder. Nanoparticles (NPs) are being developed as in vivo targeted delivery systems, which cross the blood-brain barrier improve pharmacokinetics effectiveness. Here, biodegradable proteinoids were synthesized by thermal step-growth polymerization from amino acids l-glutamic acid, l-phenylalanine l-histidine poly (l-lactic acid). Proteinoid NPs containing RSP then formed self-assembly,...
Background: Targeted nanoparticle (NP)-based drug delivery systems enable administration of non-soluble drugs and enhance their efficacy. The arginine-glycine-aspartic acid (RGD) motif is a known recognition site integrins, RGD receptors are overexpressed in tumors neovasculature can be used as targets for tumor treatment. Cannabidiol (CBD), the main non-psychotropic phytocannabinoid Cannabis sativa, exhibits various therapeutic effects has antitumor properties. Encapsulation CBD within...
Abstract Proteinoid nanoparticles composed of l ‐lysine and ‐phenylalanine were prepared showed enantioselective adsorption ‐amino acids at various pH values, emphasizing the chiral nature particles. The was examined using circular dichroism, isothermal titration calorimetry ζ‐potential measurements. Positively charged ammonium moieties on proteinoid surface are most likely responsible for owing to their chirality which originates from ‐lysine. Accordingly, a higher enantiomeric excess found...