A5066531281- Neonatal Respiratory Health Research
- Problem and Project Based Learning
- Congenital Diaphragmatic Hernia Studies
- Vitamin D Research Studies
- Cancer, Hypoxia, and Metabolism
- Innovations in Medical Education
- Respiratory Support and Mechanisms
- Airway Management and Intubation Techniques
- Bone health and osteoporosis research
- ATP Synthase and ATPases Research
- Renal and related cancers
- Clinical Reasoning and Diagnostic Skills
- Renal cell carcinoma treatment
- Protein Tyrosine Phosphatases
- Immune cells in cancer
- Systemic Sclerosis and Related Diseases
- Physical Unclonable Functions (PUFs) and Hardware Security
- Vitamin C and Antioxidants Research
- Adrenal Hormones and Disorders
- Restraint-Related Deaths
- Galectins and Cancer Biology
- Epigenetics and DNA Methylation
- Education and Critical Thinking Development
- Integrated Circuits and Semiconductor Failure Analysis
- MicroRNA in disease regulation
University Medical Center Freiburg
2024-2025
University of Freiburg
2024-2025
Guangxi Medical University
2020-2024
First Affiliated Hospital of GuangXi Medical University
2020-2024
Nanjing Maternity and Child Health Care Hospital
2024
Nanjing Medical University
2024
Zhengzhou University
2024
Encoded by PTPN11 , the Src-homology 2 domain-containing phosphatase (SHP2) integrates signals from various membrane-bound receptors such as receptor tyrosine kinases (RTKs), cytokine and integrin thereby promotes cell survival proliferation. Activating mutations in gene may trigger signaling pathways leading to development of hematological malignancies, but are rarely found solid tumors. Yet, aberrant SHP2 expression or activation has implications development, progression metastasis many...
Oncogenic KRAS mutations drive metabolic rewiring in pancreatic ductal adenocarcinoma (PDAC). Src-homology 2 domain-containing phosphatase (SHP2) is essential for full activity and promising dual SHP2/mitogen-activated protein kinase (MAPK) inhibition currently being tested clinical trials. Exploitable adaptations may contribute to an invariably evolving resistance. To understand the changes induced by inhibition, we comprehensively cell lines, endogenous tumor models, patient-derived...
To investigate the effect and underlying mechanism of exosomes secreted by human umbilical cord mesenchymal stem cells (hUCMSCs) on diffuse alveolar hemorrhage (DAH) in murine lupus.Exosomes were extracted from cultured hUCMSCs ultracentrifugation. The expressions exosome markers (Alix, CD63 TSG101) measured for identification hUCMSC-derived (hUCMSC-exosomes). DAH mice was revealed H&E staining. primary macrophages isolated bronchoalveolar lavage fluid (BALF) mice. M1 macrophage (iNOS, IL-6,...
Abstract Background In view of the harsh reality Chinese paediatricians face, challenge paediatric education is about instilling not only knowledge and clinical skills but also resilience beliefs. The aim study to explore a more effective method than traditional lecture-based learning (LBL) model for optimizing educational outcomes by establishing an innovative, comprehensive, case-based (CBL) combined with micro-film technique (MF + CBL). This approach has four important components:...
Background Pancreatic cancer has a poor prognosis. Targeting Kirsten Rat Sarcoma (KRAS) mutation and its related pathways may enhance immunotherapy efficacy. While in vivo monitoring of therapeutic response immune cell migration remains challenging, Fluorine‐19 MRI ( 19 F MRI) allow noninvasive longitudinal imaging cells. Purpose Evaluating the potential for changes tumor microenvironment, to combined SHP2/MEK inhibition. Study Type Pre‐clinical animal study. Animal Model Murine genetically...
Background The establishment of appropriate medical reference intervals (RIs) for specific populations is crucial accurate diagnosis and treatment disease. However, the RIs 25-hydroxyvitamin D (25(OH)D) in Chinese pediatric individuals are currently not available. This retrospective study aimed to establish serum Nanjing area China.Methods After data filtering deletion outliers, 138,150 25(OH)D records were finally included this study. effects age, sex, season on levels assessed, 2.5% 97.5%...
Background Respiratory infection is a common trigger for the episode of alveolar hemorrhage in pediatric diffuse hemorrahge (DAH). Whereas, futher detailed study hasn’t been conducted. The aim this was to explore etiological spectrum, clinical features, treatment strategies and outcomes respiratory induced (RIIEAH) DAH. Methods cases DAH who had RIIEAH definite diagnosis were included. A retrospective Results 1. total 16 with 21 RIIEAHs Twelve occurred at unstable stage, 6 stable stage 3 end...
To improve the management level of general anesthesia during bronchoscopy in children with diffuse alveolar hemorrhage (DAH). A retrospective study was conducted DAH who had performed under spontaneous respiration by face mask ventilation initially from June 2021 to 2022 our hospital. (1) Thirty-four underwent 38 procedures were included. (2) General induction bolus propofol intravenous all procedures. For maintaining anesthesia, combination use and remifentanil intravenously infusion given...
Abstract Background Early-onset pharyngeal airway collapse(PAL) in infant, which presents with onset within 6-months old is relatively rare, and has not been given enough attention clinic. The aim of this study was to explore the clinical features, endoscopic findings outcomes early-onset PAL infant. Methods children were included, a retrospective conducted. Results 1. Total 26 cases included. age neonatal period 20 cases, 1 3-months 5 4 case. 2. main manifestations noisy breathing(26/26),...
Abstract Purpose To improve the management level of general anesthesia during bronchoscopy in children with diffuse alveolar hemorrhage (DAH). Methods A retrospective study was conducted DAH who had performed under spontaneous respiration by face mask ventilation initially from June 2021 to 2022 our hospital. Results 1. Thirty-four underwent 38 procedures were included. 2. General induction bolus propofol intravenous all procedures. For maintaining anesthesia, 31 (81.6%) received both and...
Abstract Background: The related factors that cause recurrent wheezing in children are complex, and premature delivery may be one of the reasons. Little is known about early preterm infants. Methods: Data sourced from 1616 born between 2007 2013 8 hospitals Guangxi China. All were followed by telephone or questionnaire through sixth year life. Children grouped characters age: Group A: gestational age (GA) ≤ 32 weeks, B: weeks < GA 37 C: 42 weeks. Results: incidence risk infants analyzed....
Abstract Background: In view of the harsh reality Chinese paediatricians face, challenge paediatric education is about instilling not only knowledge and clinical skills but also resilience beliefs. The aim study to explore a more effective method than traditional lecture-based learning (LBL) model for optimizing educational outcomes by establishing an innovative, comprehensive, case-based (CBL) combined with micro-film technique (MF+CBL). This approach has four important components:...
Abstract Background: In view of the harsh reality Chinese paediatricians face, challenge paediatric education is about instilling not only knowledge and clinical skills but also resilience beliefs. The aim study to explore a more effective method than traditional lecture-based learning (LBL) model for optimizing educational outcomes by establishing an innovative, comprehensive, case-based (CBL) combined with micro-film technique (MF+CBL). This approach has four important components:...
Abstract Background: By establishing an innovative teaching model, teachers and students can optimize the education outcome. Lecture-Based Learning (LBL) model has long been widely used as main method in medical course Chinese culture with a positive result of grades, however, negative practice. Case-Based (CBL) modified it by focusing on clinical case study, yet its limitations. The aim our study is to discuss effect applying comprehensive renewal CBL model: Micro-Film Case Based (MF+CBL)...
Abstract Background: In view of the harsh reality Chinese paediatricians face, challenge paediatric education is about instilling not only knowledge and clinical skills but also resilience beliefs. The aim study to explore a more effective method than traditional lecture-based learning (LBL) model for optimizing educational outcomes by establishing an innovative, comprehensive, case-based (CBL) combined with micro-film technique (MF+CBL). This approach has four important components:...
Abstract Background: The factors that cause recurrent wheezing in children are complex, and premature delivery may be one of these factors. Little is known about early preterm infants. Methods: Data were sourced from 1616 born between 2007 2013 8 hospitals Guangxi, China. All followed up by telephone or questionnaire through the sixth year life. Children grouped gestational age (GA): Group A, GA ≤ 32 weeks; B, weeks < 37 C, 42 weeks. Results: incidences risk for infants analysed. as...