A5100355402- Viral Infections and Immunology Research
- Renal cell carcinoma treatment
- Appendicitis Diagnosis and Management
- Abdominal Trauma and Injuries
- Renal and related cancers
- Hepatocellular Carcinoma Treatment and Prognosis
- Heavy metals in environment
- Cytokine Signaling Pathways and Interactions
- Antifungal resistance and susceptibility
- Fungal Infections and Studies
- Lipid metabolism and biosynthesis
- Tracheal and airway disorders
- Diverticular Disease and Complications
- Trace Elements in Health
- Cancer, Lipids, and Metabolism
- Chemical Synthesis and Analysis
- Immune Cell Function and Interaction
- Minimally Invasive Surgical Techniques
- Heavy Metal Exposure and Toxicity
- interferon and immune responses
- Click Chemistry and Applications
- Pleural and Pulmonary Diseases
- Advanced biosensing and bioanalysis techniques
- Congenital gastrointestinal and neural anomalies
- Gallbladder and Bile Duct Disorders
St George Hospital
2025
Sutherland Hospital
2025
UNSW Sydney
2025
Guangxi Medical University
2014-2024
First Affiliated Hospital of GuangXi Medical University
2016-2024
Weatherford College
2023
First People's Hospital of Yuhang District
2023
Triple-negative breast cancer (TNBC) is highly invasive with a poor prognosis, and chemotherapy remains the clinical treatment of choice. Paclitaxel commonly used first-line drug, but its untargeted distribution poses challenges. Inspired by antibody-drug conjugates, we develop precisely structured framework nucleic acid-programmed aptamer-paclitaxel conjugate (FAPC) chemically well-defined paclitaxel loading dosing, enabling regulation receptor-aptamer affinity to facilitate tumor-targeted...
Hirschsprung's disease (HD) is a commonly digestive malformation in children that usually requires surgery. This study aims to evaluate the short-term efficacy of conventional laparoscopic surgery (CLS), transumbilical single-hole (TU-LESS), and robotic (RS) treatment disease.90 patients with undergone at our center between 2015 2019, divided into three groups (group CLS, TU-LESS RS), were retrospectively analysed.CLS group showed no significant difference operation duration (P > 0.05) but...
Hepatoblastoma is a kind of extreme malignancy frequently diagnosed in children. Although surgical resection considered as the first-line treatment for hepatoblastoma, relatively large population patients have lost preferred opportunity surgery. Administration locoregional ablation enables local tumor control but with deficiency insufficient ablation, residual tumor, and rapid progression. In this study, we integrated 219 hepatoblastoma 121 non-cancer liver tissues to evaluate expression...
Abstract Background: Viral myocarditis (VMC) is the major cause of sudden death in adolescents. To date, no effective treatment has been identified for VMC. Studies have shown that T helper (Th) cells such as Th1, Th2, Th17, and Th22 are involved pathogenesis However, role B their impact on Th VMC unclear. In this study, we investigated cell differentiation myocardial damage an animal model Methods Results: C57BL/6 mice were infected with Coxsackievirus B3 (CVB3) intraperitoneally or...
To investigate the diagnosis and treatment of invasive pulmonary aspergillosis (IPA) in children.The clinical data 16 cases proven or probable IPA who had been our Hospital from January 2006 to June 2014 were retrospectively analyzed.Among patients, 11 males 5 females. One child 15 children IPA. Host risk included long duration use multiple broad-spectrum antibiotics cases, neutropenia 9 mechanical ventilation 3 primary immunodeficiency disease 2 long-term glucocorticoids measles congenital...
Background Single-incision laparoscopic splenectomy (SILS) remains a challenging procedure because of the technical difficulty. In this prospective study, we aimed to evaluate efficacy and safety SILS in children with massive splenomegaly. Methods Pediatric patients splenomegaly were recruited for university-affiliated hospital. The data on patient demographics, clinical features, operative variables, perioperative outcomes collected prospectively analyzed. According different surgical...
Fulminant myocarditis (FM) is associated with high mortality, and studies on soluble suppression of tumorigenicity 2 (sST2) are still scarce. The aim this study was to investigate the relationship between sST2 FM in children myocarditis. This a single-center retrospective clinical observational study. We continuously included patients diagnosed as suspected viral from December 2019 2022. A total 203 younger than 11 years old were enrolled study, 22 whom FM. level positively correlated...
Abstract Background Laparoscopic splenectomy (LS), a treatment for both benign and malignant splenic diseases, can prove technically challenging in patients with massive splenomegaly. In particular, the optimal surgical modality treating splenomegaly children remains controversial. Methods The clinicopathologic data of 289 pediatric undergoing were studied retrospective analysis. Accordingly, classified into LS surgery group open (OS) group. laparoscopy cohort, they separated two subgroups...
Background: Wilms tumour is the most common childhood renal cancer that requires development of better treatments. Nitidine chloride, a Chinese traditional medicine, could have therapeutic potential for tumour, however there been no studies to date. Methods: In-house RNA-seq was performed and public plus microarrays datasets were incorporated identifying landscape differentially expressed genes (DEGs) in tumour. Meanwhile, targets nitidine chloride acquired through combined analysis...