A5101575619- Cancer Immunotherapy and Biomarkers
- RNA modifications and cancer
- Radiomics and Machine Learning in Medical Imaging
- Ferroptosis and cancer prognosis
- Hepatocellular Carcinoma Treatment and Prognosis
- Immune cells in cancer
- Immunotherapy and Immune Responses
- RNA Research and Splicing
- Cancer-related molecular mechanisms research
- Immune Cell Function and Interaction
- Cancer-related Molecular Pathways
- Ovarian cancer diagnosis and treatment
- Galectins and Cancer Biology
- Cancer Research and Treatments
- Cancer, Hypoxia, and Metabolism
- Glycosylation and Glycoproteins Research
- Motivation and Self-Concept in Sports
- Signaling Pathways in Disease
- Liver Disease Diagnosis and Treatment
- Nanomaterials for catalytic reactions
- Glioma Diagnosis and Treatment
- Epigenetics and DNA Methylation
- Nuclear Receptors and Signaling
- HIV Research and Treatment
- Lipid metabolism and biosynthesis
Zunyi Medical University
2023-2025
First Affiliated Hospital of Xi'an Jiaotong University
2025
Nankai University
2020-2024
Zhejiang Sci-Tech University
2019-2024
Yantai University
2024
Intelligent Health (United Kingdom)
2023
First Affiliated Hospital of GuangXi Medical University
2020-2021
Guangxi Medical University
2020-2021
Anhui Medical University
2020-2021
Beijing Institute of Technology
2019
Parkinson's disease (PD), a neurodegenerative disorder with an unknown etiology, is primarily characterized by the degeneration of dopamine (DA) neurons. The prevalence PD has experienced significant surge in recent years. unidentified etiology poses limitations to development effective therapeutic interventions for this condition. Helicobacter pylori (H. pylori) infection affected approximately half global population. Mounting evidences suggest that H. plays important role through various...
Preoperative identification of hepatocellular carcinoma (HCC), combined hepatocellular-cholangiocarcinoma (cHCC-ICC), and intrahepatic cholangiocarcinoma (ICC) is essential for treatment decision making. We aimed to use ultrasound-based radiomics analysis non-invasively distinguish histopathological subtypes primary liver cancer (PLC) before surgery.We retrospectively analyzed ultrasound images 668 PLC patients, comprising 531 HCC 48 cHCC-ICC 89 ICC patients. The boundary a tumor was...
Abstract Background The molecular biomarkers of breast ductal carcinoma in situ (DCIS) have important guiding significance for individualized precision treatment. This study was intended to explore the radiomics based on ultrasound images predict expression mass type DCIS. Methods 116 patients with DCIS were included this retrospective study. features extracted images. According ratio 7:3, data sets split into training set and test set. models developed estrogen receptor (ER), progesterone...
Background: Chromosome 1p/19q codeletion is one of the most important genetic alterations for low grade gliomas (LGGs), and patients with have significantly prolonged survival compared to those without codeletion. And tumor immune microenvironment also plays a vital role in progression prognosis. However, effect on LGGs unclear. Methods: Immune cell infiltration 281 from The Cancer Genome Atlas (TCGA) 543 Chinese Glioma (CGGA) were analyzed through three bioinformatics tools: ESTIMATE...
Rationale: Psychological stress has been linked to cancer development and resistance therapy by many epidemiological clinical studies. Stress-induced immunosuppressive microenvironment hormones, in particular glucocorticoids, extensively studied. However, the impacts of other stress-related neurotransmitters, such as serotonin (5-hydroxytryptamine, 5-HT), on just start be revealed. Here, we aimed identify novel neurotransmitters involved stress-induced growth dissemination ovarian (OC)...
The reduction of cellular PD-L1 abundance through lysosomal degradation is recognized as essential for effective and sustained targeting PD-L1-dependent immune evasion in cancer. While Hsc70 can interact with to promote its degradation, the overexpression CMTM6 competitively inhibits this interaction, leading blockade degradation. To overcome issue, a meso chimeric peptide PEPPDL1 was designed specifically bind PD-1 binding domain instead Hsc70/CMTM6 domain, while also facilitate dragging...
The consumption of natural gas in China, predominantly cities, has nearly tripled over the past decade. However, there is an absence measurement-based assessment methane emissions from Chinese cities. Moreover, it challenging to separate contribution relative other major urban sources (e.g., wastewater, landfills) using only observations. Here, we use in-situ and total-column ethane observations across Yangtze River Delta, one China’s most important metropolitan areas, between 2012...
Abstract Turnover intention is a negative outcome for an organization. The purpose of this article to examine the relationships among work passion, subjective well-being, career adaptability, and turnover Chinese government employees. consists empirical study with sample 472 employees in Shandong Province, China. Participants completed series questionnaires three waves. results indicate that harmonious passion negatively related obsessive positively intention. Additionally, relationship...
Hydroxysteroid 17-Beta Dehydrogenase 6 (HSD17B6), a key protein involved in synthetizing dihydrotestosterone, is abundant the liver. Previous studies have suggested role for dihydrotestosterone modulating progress of various malignancies, and HSD17B6 dysfunction was associated with lung cancer prostate cancer. However, little known about detailed hepatocellular carcinoma (HCC).Clinical implication survival data related to expression patients HCC were obtained through TCGA, ICGC, ONCOMINE,...
Tumor glycolysis is a major promoter of carcinogenesis and cancer progression. Given its complex mechanisms interactions, comprehensive analysis needed to reveal clinical significance molecular features. On the basis well-established gene expression signature, we quantified 8633 patients with different types from Cancer Genome Atlas (TCGA) evaluated their prognostic associations. High tumor glycolytic activity correlated inferior overall survival in pan-cancer (hazard ratio: 1.70, 95%...
Growing evidence suggests that cisplatin and other chemotherapeutic agents promote tumor metastasis while inhibiting growth, which is a critical issue for certain patients in clinical practices. However, the role of chemotherapeutics promoting molecular mechanism involved are unclear. Here, we investigated roles lung adenocarcinoma (LUAD). We demonstrated promoted epithelial-mesenchymal transition (EMT), cell motility, vitro vivo. The bioinformatic analysis biology approaches also indicated...
Transcoelomic spread of cancer cells across the peritoneal cavity occurs in most initially diagnosed ovarian (OC) patients and accounts for cancer-related death. However, how OC interact with stromal to evade immune surveillance remains largely unexplored. Here, through an vivo genome-wide CRISPR/Cas9 screen, we identified IL20RA, which decreased dramatically during metastasis, as a key factor preventing transcoelomic metastasis OC. Reconstitution IL20RA highly metastatic greatly suppresses...
BACKGROUND:The tumor microenvironment is largely orchestrated by the immune cells. Considerable evidence has shown their excellent clinicopathological application value in assessment of clinical outcomes and immunotherapy efficacy. Hence, a moderate, individualized prognostic signature based on cells that can estimate prognosis reflect hepatocellular carcinoma (HCC) patients greatly needed. MATERIAL AND METHODS:Here, we systematically analyzed expression differences survival prediction...
A 2D NiCo-MOF bimetallic nanosheet was constructed as a single-atom catalyst and it exhibited excellent performance for the hydrogenation of various nitroarenes aldehyde compounds, in terms high conversion, selectivity rapid kinetics.
The lack of tumor specific antigens (TSA) and the immune tolerance are two major obstacles for immunotherapy cancer. Current checkpoint inhibitors (ICIs) show clinical responses in only limited subsets cancer patients, which, to some extent, depends on mutation load cells that may generate neoantigens. Here, we aimed a neoantigen MDP exhibit stronger anti-tumor efficacy. Methods: In this study, utilized chemically modified sialic acid precursor tetra acetyl-N-azidoacetyl-mannosamine...
Splicing factors (SFs) have been increasingly documented to perturb the genome of cancers. However, little is known about alterations SFs in hepatocellular carcinoma (HCC). This study comprehensively delineated genomic and epigenomic characteristics 404 HCC based on multi-omics data from Cancer Genome Atlas database. The analysis revealed several clinically relevant that could be effective biomarkers for monitoring onset prognosis (such as, HSPB1, DDX39A, NELFE, which were three most...
Long non-coding RNA known as ASB16 antisense RNA1 (ASB16-AS1) has been proven to be an oncogene, and the relationship between ASB16-AS1 immunity is still under studied. This study aims explore expression prognostic potential of ASB16-AS1, visualize immune infiltration in pan-cancer analysis. We clarified patterns its with prognosis through multi-platform multi-database sources. also verified function liver hepatocellular carcinoma (LIHC). A variety cell content evaluation methods were used...
Objectives To determine the performance of machine learning (ML)‐based ultrasomic analysis subacromial impingement syndrome (SIS) stage evaluation. Methods In this retrospective study, 324 patients with SIS were included. The was evaluated a Neer test. Regions musculi supraspinatus manually segmented by an experienced radiologist. Then, 5936 features extracted from Ultrasomics Platform software. Wilcoxon test used to identify differentially expressed radiomic features. these submitted least...