A5100672235- Epilepsy research and treatment
- Pharmacological Effects and Toxicity Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Cancer Cells and Metastasis
- PARP inhibition in cancer therapy
- Multiple Sclerosis Research Studies
- Neurogenesis and neuroplasticity mechanisms
- Drug Transport and Resistance Mechanisms
- Diet and metabolism studies
- Adipose Tissue and Metabolism
- Immune Cell Function and Interaction
- RNA regulation and disease
- Birth, Development, and Health
- Cancer-related molecular mechanisms research
- Biochemical effects in animals
- Nutritional Studies and Diet
- Pneumocystis jirovecii pneumonia detection and treatment
- Pain Mechanisms and Treatments
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Peripheral Neuropathies and Disorders
- Reproductive System and Pregnancy
- Sirtuins and Resveratrol in Medicine
- Childhood Cancer Survivors' Quality of Life
- Gastric Cancer Management and Outcomes
- Traditional Chinese Medicine Analysis
Loyola University Chicago
2023-2025
Henan University
2017-2025
Institute of Psychology, Chinese Academy of Sciences
2021-2025
Tianjin International Joint Academy of Biomedicine
2016-2025
Hebei Medical University
2017-2025
Xingtai People's Hospital
2023-2025
Southern Medical University
2025
Soochow University
2021-2024
Anhui University
2024
Hangzhou Normal University
2024
Recent studies demonstrated that cancer stem cells (CSCs) have higher tumorigenesis properties than those of differentiated and transcriptional factor-SOX2 plays a vital role in maintaining the unique CSCs; however, function underlying mechanism SOX2 carcinogenesis lung are still elusive. This study applied immunohistochemistry to analyze expression human tissues normal individuals as well patients with adenocarcinoma, squamous cell carcinoma, large small carcinoma specific overexpression...
Abstract Interleukin 35 (IL-35) is a novel member of the IL-12 family, consisting an EBV-induced gene 3 (EBI3) subunit and P35 subunit. IL-35 immune-suppressive cytokine mainly produced by regulatory T cells. However, role in cancer metastasis progression not well understood. Here we demonstrate that overexpressed human pancreatic ductal adenocarcinoma (PDAC) tissues, overexpression associated with poor prognosis PDAC patients. has critical roles cell extravasation facilitating adhesion to...
As an important component of the tumor microenvironment, CD4+ CD25+ Tregs reduce antitumor immunity, promote angiogenesis and metastasis in breast cancer. However, their function regulating "stemness" cells communication between cancer stem (CSCs) remain elusive. Here, we disclose that primarily cultured isolated from breast-tumor-bearing Foxp3-EGFP mouse upregulate stemness property cells. increased side-population Aldehyde dehydrogenase-bright population cells, promoted sphere formation a...
Abstract This study aims to investigate the association between trajectories of cognition and body mass index (BMI) among Chinese middle old-aged adults. A total 5693 adults (age 45 +) whose cognitive score is higher than average at baseline were included from China Health Retirement Longitudinal Study (CHARLS:2011–2015). Cognitive function was measured by Mini-mental state examination (MMSE) in version. The Group-based trajectory modeling (GBTM) adopted identify potential heterogeneity...
Legumain is a member of the asparaginyl endopeptidase family that over-expressed in response to hypoxic stress on mammary adenocarcinoma, colorectal cancer, proliferating endothelial cells, and tumor-associated macrophages (TAMs). Here, we demonstrate elevated expression legumain ovarian cancer by proteomic approach using isobaric tags for relative absolute quantification (iTRAQ) followed liquid chromatography-mass spectrometry (LC-MS/MS). To investigate relationship between development,...
Tumour microenvironment (TME) contributes significantly towards potentiating the stemness and metastasis properties of cancer cells.IL6-Stat3 is one important cell signaling pathways in mediating communication between tumour immune cells.Here, we have systematically developed a novel anti-CD44 antibody-mediated liposomal nanoparticle delivery system loaded with anti-IL6R antibody, which could specifically target TME CD44 + breast cells different mouse models for triple negative luminal...
ABSTRACT Inflammation induced oligodendrocyte death and CNS demyelination, are key features of multiple sclerosis (MS). Inflammation-triggered endoplasmic reticulum (ER) stress oxidative promote tissue damage in MS its preclinical animal model, experimental autoimmune encephalitis (EAE). Compound AA147 is a potent activator the ATF6 signaling arm unfolded protein response (UPR) that can also induce antioxidant through activation NRF2 pathway neuronal cells. Previous work showed protects...
ABSTRACT Portal hypertension (PH) is a collection of clinical conditions that occur due to an enduring elevation pressure within the portal venous system, and it closely linked prognosis liver disease patients. The hepatic gradient (HVPG) considered diagnostic standard for PH, but its use limited invasive, costly, radiological nature. As such, search noninvasive methods focus researchers worldwide. This review article provides overview routine novel blood test indicators, as well models...
Inflammation-induced oligodendrocyte death and CNS demyelination are key features of multiple sclerosis (MS). Inflammation-triggered endoplasmic reticulum (ER) stress oxidative promote tissue damage in MS its preclinical animal model, experimental autoimmune encephalitis (EAE). Compound AA147 is a potent activator the ATF6 signaling arm unfolded protein response (UPR) that can also induce antioxidant through activation NRF2 pathway neuronal cells. Previous work showed protects tissues...
Abstract Objective To explore the postoperative risk factors of Merkel cell carcinoma patients who have undergone surgical resection, and to construct a survival prognosis column chart. Method Patients diagnosed with underwent resection from 2000 2019 were selected surveillance, epidemiology, end results database. COX regression analysis was used screen for independent prognostic factors, chart constructed. The predictive performance evaluated using consistency index, receiver operating...
The primary pathology of rheumatoid arthritis (RA) involves the invasion extracellular matrix (ECM) articular cartilage by inflammation-activated fibroblast-like synoviocytes (FLS), a process targeted most RA therapeutic drugs. However, absence an efficient in vitro model for evaluating FLS hinders relevant drug screening and mechanism research. To address this, novel three-dimensional (3D) chondrocytic spheroid that mimics ECM has been developed, along with corresponding indices to quantify...
Valproic acid (VPA) is one of the most widely-prescribed antiepileptic drugs, as VPA-induced hepatotoxicity severe adverse reaction that can lead to death. The objective this study was gain an understanding dysregulated lipid metabolism in mechanism hepatotoxicity. Nontargeted lipidomics analysis with LC-Q-TOF/MS performed explore differential lipids from patient serum and L02 cells. Lipidomics data interpretation augmented by gene expression analyses for key enzymes pathways. From...
Abstract TIFA, also called T2BP, was first identified using yeast two-hybrid screening. Our previous work showed that TIFA suppresses hepatocellular carcinoma (HCC) progression via apoptosis and cell cycle arrest. However, the mechanism by which this suppression occurs remains unclear. Here we demonstrated TIFA-induced demonstrates two distinct time patterns (i.e., at 48 h >7 days) when reconstitution occurs. Moreover, found MALT1 (a competitor of TIFA) plays a crucial role in...
The inflammatory environment of demyelinated lesions in multiple sclerosis (MS) patients contributes to remyelination failure. Inflammation activates a cytoprotective pathway, the integrated stress response (ISR), but it remains unclear whether enhancing ISR can improve an environment. To examine this possibility, stage experimental autoimmune encephalomyelitis (EAE), as well mouse model that incorporates cuprizone-induced demyelination along with CNS delivery proinflammatory cytokine IFN-γ...
Rationale: Psychological stress has been linked to cancer development and resistance therapy by many epidemiological clinical studies. Stress-induced immunosuppressive microenvironment hormones, in particular glucocorticoids, extensively studied. However, the impacts of other stress-related neurotransmitters, such as serotonin (5-hydroxytryptamine, 5-HT), on just start be revealed. Here, we aimed identify novel neurotransmitters involved stress-induced growth dissemination ovarian (OC)...
Ovarian cancer (OV) is a common type of carcinoma in females. Many studies have reported that ferroptosis associated with the prognosis OV patients. However, mechanism by which this occurs not well understood. We utilized Genotype-Tissue Expression (GTEx) and The Cancer Genome Atlas (TCGA) to identify ferroptosis-related genes OV. In present study, we applied Cox regression analysis select hub used least absolute shrinkage selection operator construct prediction model mRNA expression...