A5100317729- Nanoparticle-Based Drug Delivery
- Crystallization and Solubility Studies
- Surface Modification and Superhydrophobicity
- Nanoplatforms for cancer theranostics
- X-ray Diffraction in Crystallography
- Advanced Sensor and Energy Harvesting Materials
- Immune Cell Function and Interaction
- Advanced Drug Delivery Systems
- Immune cells in cancer
- Drug Solubulity and Delivery Systems
- RNA Interference and Gene Delivery
- Immunotherapy and Immune Responses
- Luminescence Properties of Advanced Materials
- Electrospun Nanofibers in Biomedical Applications
- Glycosylation and Glycoproteins Research
- Tuberculosis Research and Epidemiology
- Conducting polymers and applications
- Crystallography and molecular interactions
- Polydiacetylene-based materials and applications
- Polymer composites and self-healing
- Carbon and Quantum Dots Applications
- Supercapacitor Materials and Fabrication
- Salmonella and Campylobacter epidemiology
- Gas Sensing Nanomaterials and Sensors
- Drug Transport and Resistance Mechanisms
Lanzhou Jiaotong University
2013-2025
Ningxia Medical University
2015-2024
Peking University
2016-2024
Sichuan University
2022-2024
China Pharmaceutical University
2017-2024
First Hospital of Jilin University
2023-2024
Jilin University
2006-2024
Xinxiang Medical University
2020-2024
Ministry of Education of the People's Republic of China
2024
State Key Laboratory of Oral Diseases
2022-2023
Most of the conventional chemotherapeutic agents used for cancer chemotherapy suffer from multidrug resistance tumor cells and poor antitumor efficacy. Based on physiological differences between normal tissue tissue, one effective approach to improve efficacy is develop pH-sensitive polymeric micellar delivery systems. The copolymers with reversible protonation–deprotonation core units or acid-liable bonds therapeutic micelle-forming can be form micelles extracellular intracellular drug...
Recent studies demonstrated that cancer stem cells (CSCs) have higher tumorigenesis properties than those of differentiated and transcriptional factor-SOX2 plays a vital role in maintaining the unique CSCs; however, function underlying mechanism SOX2 carcinogenesis lung are still elusive. This study applied immunohistochemistry to analyze expression human tissues normal individuals as well patients with adenocarcinoma, squamous cell carcinoma, large small carcinoma specific overexpression...
Rationale: Mucosal-associated invariant T (MAIT) cells have been proven to play an important role in host defense against mycobacterial infection animal models; however, the functional of MAIT patients with active tuberculosis (TB) is still largely unknown.Objectives: To understand clinical features and functions TB.Methods: were analyzed pulmonary TB, tuberculous pleurisy, peritonitis by flow cytometry. The compared between TB healthy control subjects.Measurements Main Results: frequency...
An in-situ polymerization to coat fabrics with polydopamine-encapsulated octadecylamine endows the self-cleaning and self-healing abilities. The treated fabric exhibits after losing its hydrophobicity. It is durable against washing mechanical abrasion without changing Thanks versatile adhesive property of polydopamine, approach compatibile a variety substrates, such as fabrics, glass, sponge, paper, polymeric materials.
3D porous carbonaceous materials were prepared by combining pre-carbonization and KOH activation with sakura petals as raw materials. The carbon (SAC-4) exhibits a high specific surface area, suitable pore size distribution, low proportion of oxygen-rich groups N functional groups, partially graphitized phase, which are very beneficial for the electrochemical performance material supercapacitor electrode. In step, when mass ratio to (SC) is 4, prepared. A maximal capacitance 265.8 F g-1...
Silk fibroin (SF) is widely used to fabricate biomaterials for skin related wound caring or monitoring, and its hydrogel state are preferred their adaptability easy use. However, in-depth development of SF restricted by limited mechanical strength, increased risk infection, inability accelerate tissue healing. Therefore, a structure-function pluralistic modification strategy using composite system metal organic framework (MOF) as bridge expanding SF's biomedical application proposed. After...
The design of materials with self-healing hydrophobicity induced by stimuli such as temperature, humidity, and pH has raised considerable interest because the high practical potential materials. Mechanically superhydrophobicity was realized facilely coating textiles polydopamine (PDA) nanocapsule-encapsulated hydrophobic agents octadecylamine (ODA) octadecanethiol (ODT). nanocapsules trapped inside endow fast ability; once is lost damage to surface chemistry, are released multiple mechanical...
To achieve synergistic therapeutic efficacy and prevent cancer relapse, chemotherapy immunotherapy have been combined as a new modality for tumor treatment. In this work, we designed redox-responsive immunostimulatory polymeric prodrug carrier, PSSN10, programmable co-delivery of an immune checkpoint inhibitor NLG919 (NLG) chemotherapeutic doxorubicin (DOX). NLG-containing PSSN10 polymers were self-assembled into nano-sized micelles that served carrier to load DOX (DOX/PSSN10 micelles)....
Cancer metastasis is the leading cause of high mortality and disease recurrence in breast cancer. In this study, a novel tumor microenvironment charge reversal polymetformin (PMet)-based nanosystem co-delivering doxorubicin (DOX) plasmid encoding IL-12 gene (pIL-12) was developed for chemo–gene combination therapy on metastatic Cationic PMet readily self-assembled into micelles DOX physical encapsulation pIL-12 complexation, hyaluronidase-sensitive thiolated hyaluronic acid (HA-SH) then...
Immunochemotherapy is viewed as a promising approach for cancer therapy via combination treatment with immune-modulating drugs and chemotherapeutic drugs. A novel dual-functional immunostimulatory polymeric prodrug carrier PEG2k-Fmoc-1-MT was developed simultaneously delivering 1-methyl tryptophan (1-MT) of an indoleamine 2,3-dioxygenase (IDO) inhibitor doxorubicin (DOX) breast immunochemotherapy. DOX/PEG2k-Fmoc-1-MT micelles were more effective in cell proliferation inhibition apoptosis...