A5103023108- Drug Solubulity and Delivery Systems
- Immunotherapy and Immune Responses
- RNA Interference and Gene Delivery
- Nanoparticle-Based Drug Delivery
- Crystallization and Solubility Studies
- Advanced Drug Delivery Systems
- Pharmacological Effects of Natural Compounds
- Immune Response and Inflammation
- Ginseng Biological Effects and Applications
- Nanoplatforms for cancer theranostics
- Drug Transport and Resistance Mechanisms
- Advancements in Transdermal Drug Delivery
- Analytical Chemistry and Chromatography
- Polysaccharides and Plant Cell Walls
- Immune Cell Function and Interaction
- Gut microbiota and health
- Glycosylation and Glycoproteins Research
- Surfactants and Colloidal Systems
- Proteoglycans and glycosaminoglycans research
- Monoclonal and Polyclonal Antibodies Research
- Natural product bioactivities and synthesis
- Carbon and Quantum Dots Applications
- Phytochemistry and Bioactivity Studies
- Virus-based gene therapy research
- Immune cells in cancer
Ningxia Medical University
2016-2025
University of Chinese Academy of Sciences
2025
University of Science and Technology Beijing
2024
Huazhong Agricultural University
2020-2022
Xijing Hospital
2003-2021
National Clinical Research Center for Digestive Diseases
2021
Sichuan Agricultural University
2018
Ningxia Medical University General Hospital
2017
Tianjin Agricultural University
2016
Nationwide Children's Hospital
2013
Most of the conventional chemotherapeutic agents used for cancer chemotherapy suffer from multidrug resistance tumor cells and poor antitumor efficacy. Based on physiological differences between normal tissue tissue, one effective approach to improve efficacy is develop pH-sensitive polymeric micellar delivery systems. The copolymers with reversible protonation–deprotonation core units or acid-liable bonds therapeutic micelle-forming can be form micelles extracellular intracellular drug...
The purpose of this study was to increase the dissolution glycyrrhetinic acid (GA) by preparing ternary solid dispersion (TSD) systems containing alkalizers, and explore modulating mechanism alkalizers in systems. GA TSDs were prepared hot melt extrusion (HME) with Kollidon® VA64 as carrier L-arginine/meglumine alkalizers. vitro release TSD investigated a test, dissociation constant (pKa) used describe ionization degree drug different pH buffers. Scanning electron microscopy (SEM),...
Abstract Fibers of chitosan and polyethylene glycol (PEG), with salicylic acid as model drug incorporated in different concentrations, were obtained by spinning their solution through a viscose‐type spinneret into coagulating bath containing aqueous tripolyphosphate ethanol. Chemical, morphological, mechanical properties characterization carried out, well the studies factors that influence releasing from chitosan/PEG fibers. These included component ratio PEG, loaded amount acid, pH ionic...
Ulcerative colitis (UC) is a chronic inflammatory disease that affects the gastrointestinal tract and characterized by immune dysregulation. Oral administration of nanoformulations containing immunomodulators desirable approach to treating UC. However, low drug-loading (<10%, typically), premature drug release, systemic absorption these continue be significant challenges restricting clinical applications. Herein, we developed colon-targeted piperine-glycyrrhizic acid nanocrystals...
Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized by abnormal activation of CD4
The structural disruption of intestinal barrier and excessive reactive oxygen/nitrogen species (RONS) generation are two intertwined factors that drive the occurrence development ulcerative colitis (UC). Synchronously restoring mitigating excess RONS is a promising strategy for UC management, but its treatment outcomes still hindered by low drug accumulation retention in colonic lesions. Inspired intestine colonizing bacterium, we developed mucoadhesive probiotic Akkermansia...
Background/Objectives: Ferroptosis, a type of programmed cell death, is mainly associated with disruptions in iron metabolism, imbalances the amino acid antioxidant system, and build-up lipid peroxides. Triple-negative breast cancer (TNBC) has dismal prognosis. Since activating ferroptosis can suppress proliferation, it holds promise as novel therapeutic target for patients. Thus, objective this study was to clarify mechanism TNBC, aiming find new treatment strategies TNBC Methods: We...
Abstract Ulcerative colitis (UC) leads to complex alterations in the intestinal microenvironment, with gut microbiota dysbiosis and excessive reactive oxygen species (ROS) being major drivers. Previously, microecological preparations have been used restore homeostasis demonstrated considerable potential; however, efficacy is hindered due hostile environment gastrointestinal tract high ROS levels at lesion sites. Accordingly, a multienzyme mimicking vanadium carbide (V2C) MXenzyme armored...
Fibers of alginate and polyethylene glycol (PEG), with salicylic acid (SA) as model drug incorporated in different concentrations, were obtained by spinning their solution through a viscose-type spinneret into coagulating bath containing aqueous CaCl(2) ethanol. Chemical, morphological, mechanical properties characterization carried out, well the studies factors that influence releasing from alginate/PEG fibers. These included component ratio PEG, loaded amount SA, pH, ionic strength release...
A novel CD44 receptor targeting and endosome pH-sensitive dual functional hyaluronic acid–deoxycholic acid–histidine (HA-DOCA-His) micellar system was designed for intracellular paclitaxel (PTX) delivery. The HA-DOCA-His micelles exhibited desirable pH (5.0–6.0)-induced aggregation deformation behavior verified by size distribution, critical concentration, zeta potential changes. presented excellent encapsulation efficiency loading capacity of 90.0% 18.9% PTX, respectively. PTX release from...