A5101806214- Moyamoya disease diagnosis and treatment
- Neurological Complications and Syndromes
- Intracranial Aneurysms: Treatment and Complications
- Pregnancy and preeclampsia studies
- Angiogenesis and VEGF in Cancer
- RNA modifications and cancer
- Wnt/β-catenin signaling in development and cancer
- Systemic Sclerosis and Related Diseases
- Aortic Disease and Treatment Approaches
- T-cell and Retrovirus Studies
- Hedgehog Signaling Pathway Studies
- Cardiac electrophysiology and arrhythmias
- Apelin-related biomedical research
- Radiopharmaceutical Chemistry and Applications
- Blood disorders and treatments
- Cardiac pacing and defibrillation studies
- Cancer, Lipids, and Metabolism
- Cancer-related Molecular Pathways
- Heart Failure Treatment and Management
- Ferroptosis and cancer prognosis
- Eosinophilic Disorders and Syndromes
- Lung Cancer Treatments and Mutations
- Synthesis and Biological Evaluation
- Cerebrovascular and Carotid Artery Diseases
- Head and Neck Cancer Studies
University of Chinese Academy of Sciences
2024-2025
Zhongnan Hospital of Wuhan University
2024
Wuhan University
2024
Central South University
2018-2020
Xiangya Hospital Central South University
2018-2020
Capital Medical University
2013
Beijing Chao-Yang Hospital
2013
China Medical University
2013
Fibrotic animal models are critical for the pathogenesis investigations and drug explorations in systemic sclerosis (SSc). The bleomycin (BLM)-induced mouse model is classical most widely used fibrosis model. However, traditional subcutaneous injection of BLM rarely induced diffuse skin lung lesions. Hypochlorous acid (HOCl)-induced mice a more representative that have cutaneous lesions, renal involvement. fibrotic immunological features this not fully elucidated. Here, we injected BALB/c...
Background/Objectives: Ferroptosis, a type of programmed cell death, is mainly associated with disruptions in iron metabolism, imbalances the amino acid antioxidant system, and build-up lipid peroxides. Triple-negative breast cancer (TNBC) has dismal prognosis. Since activating ferroptosis can suppress proliferation, it holds promise as novel therapeutic target for patients. Thus, objective this study was to clarify mechanism TNBC, aiming find new treatment strategies TNBC Methods: We...
Abstract Background Triple negative breast cancer (TNBC) is a type of that for oestrogen receptor, progesterone receptor and human epidermal growth factor 2, highly malignant aggressive, lacks corresponding targeted therapy, has relatively poor prognosis. Therefore, understanding the mechanism TNBC development formulating effective treatment strategies inducing cell death are still urgent tasks in TNBC. Research shown uncarboxylated osteocalcin can promote proliferation prostate cancer, lung...
Abstract Background Autoantibodies specific to the angiotensin II type I receptor (anti-AT 1 -AR) have been implicated in pathology of congestive heart failure (CHF). Anti-AT -AR may be associated with left ventricular function CHF patients treated perindopril. Methods Synthetic (AT -R) peptides served as target antigen. ELISA was used screen sera 156 patients, which were divided into positive and negative groups based on their anti-AT reactivity. Echocardiography a 6-minute walk test...
<h3>Objectives</h3> Previously, we reported that autoantibodies specific for the angiotensin II type 1 receptor (anti-AT<sub>1</sub>-AR) is implicated in pathogenesis of congestive heart failure (CHF). We hypothesised presence anti-AT<sub>1</sub>-AR associated with left ventricular function CHF patients response to perindopril. <h3>Methods</h3> Synthetic (AT<sub>1</sub>-R) peptides were used as target antigen. An ELISA was screen sera 156 NYHA class II-IV. The then divided into positive or...
<h3>Objectives</h3> Preeclampsia is the leading cause of maternal and neonatal morbidity mortality with incompletely understood pathogenesis. The purpose current study to determine whether there a relationship between presence autoantibody against M<sub>2</sub>-muscarinic receptor severe preeclampsia. <h3>Methods</h3> Peptide corresponding amino acid sequences second extracellular loops M<sub>2</sub> was synthesised as antigens test 60 patients preeclampsia, normal pregnant women 40...