A5100428144- Lipoproteins and Cardiovascular Health
- Phytochemicals and Antioxidant Activities
- Receptor Mechanisms and Signaling
- Ovarian cancer diagnosis and treatment
- Spectroscopy and Laser Applications
- Cancer, Lipids, and Metabolism
- Hormonal Regulation and Hypertension
- Antiplatelet Therapy and Cardiovascular Diseases
- Acute Myocardial Infarction Research
- Essential Oils and Antimicrobial Activity
- MicroRNA in disease regulation
- Phytochemistry and Biological Activities
- Computational Drug Discovery Methods
- Genomics, phytochemicals, and oxidative stress
- Cancer-related molecular mechanisms research
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Circular RNAs in diseases
- Natural product bioactivities and synthesis
- Advanced Sensor and Control Systems
- Renin-Angiotensin System Studies
- Spectroscopy and Chemometric Analyses
- Adipose Tissue and Metabolism
- Advanced Algorithms and Applications
- Plant tissue culture and regeneration
- Pharmacological Effects of Natural Compounds
Agricultural Research Service
2018-2025
Beltsville Human Nutrition Research Center
2018-2025
University of Maryland, College Park
2017-2025
Guangzhou University of Chinese Medicine
2023-2025
Ohio University
2025
Heze Medical College
2025
Sun Yat-sen University
2012-2024
Sun Yat-sen University Cancer Center
2012-2024
Qilu University of Technology
2018-2024
Anyang Institute of Technology
2023-2024
BACKGROUND Sensitive and specific biomarkers for the early detection of esophageal squamous cell carcinoma (ESCC) are urgently needed to reduce high morbidity mortality disease. The discovery serum microRNAs (miRNAs) their unique concentration profiles in patients with various diseases makes them attractive, novel noninvasive tumor diagnosis. In this study, we investigated miRNA profile ESCC develop a diagnostic biomarker. METHODS Serum samples were taken from 290 140 age- sex-matched...
Turmeric (Curcuma longa L.) is a perennial tuberous plant from the genus Curcuma (Zingiberaceae) and has been widely used in foods for thousands of years. The present study examined ethanol extract turmeric its chemical composition, antimicrobial activity, free radical scavenging properties. UHPLC-MS/MS analysis tentatively identified eight compounds extract. Potential effects 0.1, 1.0, 10 mg equivalents (TE)/mL were evaluated vitro against variety Gram-negative bacteria (i.e., Escherichia...
OBJECTIVE The aim of the current study is to determine impact elevated lipoprotein(a) [Lp(a)] on cardiovascular events (CVEs) in stable coronary artery disease (CAD) patients with different glucose metabolism status. RESEARCH DESIGN AND METHODS In this multicenter study, we consecutively enrolled 5,143 from March 2011 February 2015. Patients were categorized according status (diabetes mellitus [DM], pre–diabetes [pre-DM], and normal regulation [NGR]) levels further classified into 12 groups...
Type 2 diabetes mellitus (T2D), rapidly increasing to epidemic proportions, globally escalates cardiovascular disease risk. Although intensive interventions and comprehensive management of environmental risks factors for T2D are associated with reduced disease, such approaches limited individuals high genetic In this study we investigated possible associations ACE2 polymorphisms in Uygur patients T2D. 275 272 non-diabetic were enrolled as participants. 14 genotyped by Matrix-assisted laser...
There is no current consensus on the role of chemotherapy in addition to radiation for postoperative adjuvant treatment patients with early-stage cervical cancer adverse pathological factors.To evaluate clinical benefits sequential chemoradiation (SCRT) and concurrent (CCRT) compared alone (RT) as a cancer.After radical hysterectomy at 1 8 participating hospitals China, FIGO (International Federation Gynecology Obstetrics) stage IB IIA factors were randomized 1:1:1 receive RT, CCRT, or SCRT....
Abstract Background The atherogenicity of remnant cholesterol (RC) has been underlined by recent guidelines, which was linked to coronary artery disease (CAD), especially for patients with diabetes mellitus (DM). This study aimed examine the prognostic value plasma RC in CAD under different glucose metabolism status. Methods Fasting were directly calculated or measured 4331 CAD. Patients followed occurrence major adverse cardiovascular events (MACEs) and categorized according both status...
This study investigated whether and how gypenosides from jiaogulan tea at 100 300 mg/kg/day levels could reduce the development of overweight insulin resistance in C57 BL/6J mice fed a high-fat diet 12 weeks. The supplement significantly reduced final body weight, plasma total cholesterol, homeostasis model assessment-estimated (HOMA-IR) index by 19.9%, 40%, 36%, respectively, compared with control group. Gypenosides also increased brown adipocyte tissue activity white adipose browning....
To achieve efficient palladium-catalyzed cross-coupling reaction under mild conditions with the flexible steric bulk strategy, a series of Pd-PEPPSI (PEPPSI: pyridine-enhanced precatalyst preparation, stabilization, and initiation) complexes C1-C6 were synthesized characterized, in which unsymmetric was introduced on N-aryl ancenaphthyl skeleton. These well-defined palladium found to be excellent precatalysts for Buchwald-Hartwig amination aryl chlorides amines air. The electronic effect...
Cardiovascular benefits by reversing environmental risks factors for essential hypertension (EH) and dyslipidemia could be weaken high genetic risk. We investigated possible associations between ACE2 polymorphisms in patients with EH.Four hundred two hypertensive were enrolled an EH group 233 normotensive individuals as control from the Xinjiang region of China. Fourteen genotyped Matrix-assisted laser desorption ionization time-of-flight mass spectrometry.Participants carrying T allele (TT...
Abstract Background Elevation in small dense low-density lipoprotein (sdLDL) is common patients with diabetes mellitus (DM), which has already been reported to be associated incidence of coronary artery disease (CAD). The aim the present study was investigate prognostic value plasma sdLDL level stable CAD and DM. Methods A total 4148 consecutive were prospectively enrolled into followed up for major cardiovascular events (MACEs) 8.5 years. Plasma measured each patient by a direct method...
Background Although several studies have indicated that lipoprotein(a) is a useful prognostic predictor for patients following percutaneous coronary intervention (PCI), previous observations somewhat been limited by either small sample size or short-term follow-up. Hence, this study aimed to evaluate the impact of on long-term outcomes in large cohort stable artery disease after PCI. Methods and Results In multicenter prospective study, we consecutively enrolled 4078 undergoing PCI from...
BACKGROUND. Adoptive cell therapy (ACT) with tumor-infiltrating lymphocytes (TILs) has achieved remarkable clinical efficacy in metastatic cancers such as melanoma and cervical cancer (CC). Here, we explored the safety, feasibility, preliminary tumor response performed translational investigations of adjuvant immunotherapy using infusion autogenous TILs (auto-TILs) following concurrent chemoradiotherapy (CCRT) patients CC who had locally advanced disease.
To obtain optimal juice-making methods, three pretreatment methods were selected to evaluate their effects on the quality characteristics of jujube juices before and after lactic acid bacteria fermentation. As a result, significant differences between all detected indicators observed in fermented unfermented following different methods. Jujube pretreated with hot water soaking (HS) had better color higher levels total sugar, reducing sugar free amino acids than those boiling steeping (BS)...
Increasing soil salinization has led to severe losses of plant yield and quality. Thus, it is urgent investigate the molecular mechanism salt stress response. In this study, we took systematically analyzed cotton root response by single-cell transcriptomics technology; 56,281 high-quality cells were totally obtained from 5-days-old lateral tips Gossypium arboreum under natural growth different salt-treatment conditions. Ten cell types with an array novel marker genes synthetically identified...
The water and ethanol extracts of huangqin, the roots
Abstract A series of Pd–PEPPSI complexes were designed and synthesized. The relationship between catalyst structure properties was systematically investigated. It revealed that “bulky‐yet‐flexible” C3 bearing ancenaphthyl backbone a highly efficient precatalyst could be successfully employed in Suzuki–Miyaura reactions (hetero)aryl chlorides with (hetero)arylboronic acids at low palladium loading the presence weak inorganic base air.