A5030131824- Cancer-related molecular mechanisms research
- Aortic aneurysm repair treatments
- Renin-Angiotensin System Studies
- Cardiac Valve Diseases and Treatments
- Cardiovascular Function and Risk Factors
- Chemotherapy-induced cardiotoxicity and mitigation
- Lipoproteins and Cardiovascular Health
- Atrial Fibrillation Management and Outcomes
- Hormonal Regulation and Hypertension
- Circular RNAs in diseases
- Cardiac Structural Anomalies and Repair
- Blood Pressure and Hypertension Studies
- Ultrasound and Hyperthermia Applications
- Acute Myocardial Infarction Research
- Cardiac tumors and thrombi
- MicroRNA in disease regulation
- Cancer, Hypoxia, and Metabolism
- Cardiovascular Syncope and Autonomic Disorders
- Macrophage Migration Inhibitory Factor
- Angiogenesis and VEGF in Cancer
- Cancer Risks and Factors
- Nutrition, Genetics, and Disease
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Heart Failure Treatment and Management
- CNS Lymphoma Diagnosis and Treatment
South China University of Technology
2018-2024
Guangzhou Medical University
2013-2024
Guangzhou First People's Hospital
2013-2024
Southern Medical University
2010-2020
Nanfang Hospital
2019-2020
Tianjin Medical University Cancer Institute and Hospital
2020
National Taiwan Normal University
2007
Essential hypertension (EH) is a principal contributing factor in worldwide cardiovascular disease mortality. Although interventions that minimize environmental risk factors for EH are associated with reduced disease, such approaches limited individuals high genetic risk. In this study, we investigated possible associations between ACE2 polymorphisms and hypertension-related target organ damages south Xinjiang, China. Four hundred two hypertensive patients were enrolled as study participants...
BackgroundIdentifying effective drugs to suppress vascular inflammation is a promising strategy delay the progression of abdominal aortic aneurysm (AAA). Itaconate has vital role in regulating inflammatory activation various diseases. However, itaconate AAA unknown. In this study, we explored inhibitory effect on formation and its underlying mechanisms.MethodsQuantitative PCR, western blotting immunohistochemistry were used determine Irg1 downstream Nrf2 expression human mouse samples....
Type 2 diabetes mellitus (T2D), rapidly increasing to epidemic proportions, globally escalates cardiovascular disease risk. Although intensive interventions and comprehensive management of environmental risks factors for T2D are associated with reduced disease, such approaches limited individuals high genetic In this study we investigated possible associations ACE2 polymorphisms in Uygur patients T2D. 275 272 non-diabetic were enrolled as participants. 14 genotyped by Matrix-assisted laser...
Cardiovascular benefits by reversing environmental risks factors for essential hypertension (EH) and dyslipidemia could be weaken high genetic risk. We investigated possible associations between ACE2 polymorphisms in patients with EH.Four hundred two hypertensive were enrolled an EH group 233 normotensive individuals as control from the Xinjiang region of China. Fourteen genotyped Matrix-assisted laser desorption ionization time-of-flight mass spectrometry.Participants carrying T allele (TT...
Abdominal aortic aneurysm (AAA) is accepted as a chronic vascular inflammatory disease. However, how the response regulated during AAA formation not fully understood. This study was undertaken to determine whether long noncoding RNA (lncRNA) H19 (H19) promotes by enhancing inflammation. qRT-PCR detected upregulation of in human and mouse tissue samples. Co-staining for macrophage marker MAC-2 showed that located smooth muscle cells (VSMCs) infiltrating macrophages. In vivo overexpression...
Objective: Long noncoding RNAs (lncRNAs) may serve as specific targets for the treatment of abdominal aortic aneurysms (AAAs). LncRNA GAS5, functionally associated with smooth muscle cell (SMC) apoptosis and proliferation, is likely involved in AAA formation, but exact role GAS5 unknown. We thus explored contribution to SMC-regulated formation its underlying mechanisms. Methods: Human specimens were used verify diverse expression normal tissues. The angiotensin II (Ang II)-induced model...
Inducing cardiomyocyte proliferation is a hopeful approach for cardiac regeneration following myocardial infarction. Previous studies have shown that p21 inhibits the and regeneration. Deacetylation of by Sirt1 deacetylase may reduce abundance remove p21-induced cell cycle arrest. However, whether deacetylation deacetylate control unclear. Here, we show acetylation induces arrest, whereas blocking increases proliferation. P21 can be acetylated Sirt1, activate ubiquitination through...
The long non-coding RNA (lncRNA) PTENP1 is a pseudogene of phosphatase and tensin homologue deleted on chromosome ten (PTEN), has been implicated in smooth muscle cell (SMC) proliferation apoptosis. the PTEN. However, it unclear whether how functions apoptosis human aortic SMCs (HASMCs). Here, we hypothesised that inhibits HASMC enhances by promoting PTEN expression. PCR analysis Western blot assays respectively showed both were up-regulated dissection (AD) samples. overexpression...
Cardiovascular death (CVD) in breast cancer patients without chemotherapy (CT) or (and) radiotherapy (RT) has not been studied yet. This study evaluates the correlation between and CVD risk independent of radiotherapy.Data female receiving CT RT were retrieved from Surveillance, Epidemiology, End Result (SEER) database (2004-2015). Data divided into two cohorts: tumor resection cohort no cohort. The was expressed as standardized mortality ratios (SMRs). A 1:1 propensity score matching (PSM)...
The aim of this study was to characterize the burden valvular heart disease (VHD)-related failure (HF) in Group 20 (G20) countries.
Background Magnetic targeting may help microbubbles (MBs) reach obstructive thrombi and improve the efficacy of MB-mediated sonothrombolysis, but role magnetic in sonothrombolysis remains elusive. Objectives We investigate feasibility magnetically targeted for treatment thrombi. Materials Methods Red white thromboembolic models were established vitro vivo. The randomly assigned to control, ultrasound plus control MB (US + C-MB), M-MB), or US M-MB recombinant tissue-type plasminogen activator...
Background Primary malignant cardiac tumors (PMCTs) are fatal, but up to now, there is still a lack of survival prediction model for prognosis evaluation. We developed nomograms predict overall (OS) and cancer-specific (CSS) PMCTs by the Surveillance, Epidemiology, End Result (SEER) database. Methods A total 506 participants were identified in SEER database from 1973 2014 randomly assigned into training cohort (N = 354) validation 152). The prognostic factors Kaplan-Meier multivariate Cox...
Type 2 diabetes (T2D) is characterized by increased levels of blood glucose but increasingly recognized as a heterogeneous disease, especially its multiple discrete cardiovascular phenotypes. Genetic variations play key roles in the heterogeneity diabetic This study investigates possible associations ATP-sensitive potassium channel (KATP) variants with phenotypes among Chinese patients T2D. Six hundred thirty-six T2D and 634 non-diabetic individuals were analyzed study. Nine KATP determined...
The influences of marital status on cardiovascular death risk in patients with breast cancer remained unclear. This study aimed to evaluate the associations different cancer.A total 182,666 female were enrolled this from Surveillance, Epidemiology, and End Results (SEER) database 2010 2014, was divided into two groups: married (N=107,043) unmarried (N=75,623). A 1:1 propensity score matching (PSM) applied reduce inter-group bias between groups. Competing-risks model used assess cancer.After...
To study the cardiovascular death (CVD) risk in primary central nervous system lymphoma (PCNSL) patients with chemotherapy.We obtained 2,020 PCNSL participants and 88,613 non-central (NCNSL) chemotherapy from Surveillance, Epidemiology, End Results (SEER) database 2004 to 2015. A 1:3 propensity score matching (PSM) was used reduce imbalance between without chemotherapy, as well NCNSL chemotherapy. Competing risks regressions were conducted evaluate independent influence of on CVD.After PSM,...
Abstract Background Exosome-derived microRNAs (exo-miRs) as messengers play important roles, in the cross-talk between genetic [ATP-sensitive potassium channels ( KATP ) variant rs1799858] and environmental [elevated serum low-density lipoprotein cholesterol (LDL-C) level] factors, but plasma exo-miRs expression profile its role biological processes from genotype to phenotype remain unclear. Methods A total of 14 subjects with increased LDL-C levels (≥ 1.8 mmol/L) were enrolled study. The...
Abstract Background Atrial fibrillation (AF) is the most common cardiac arrhythmia. Type 2 diabetes (T2D) an independent risk factor for AF. The cardioembolic stroke (CS) increased when both conditions coexist. Whether angiotensin-converting enzyme (ACE2) genetic variants predict risks AF and CS in Uygur patients with T2D remain elusive. Methods A total of 547 subjects (272 controls 275 patients) were recruited to study from south Xinjiang. Eight ACE2 identified by MassARRAY system. Results...
Serum concentration of apolipoprotein B (Apo B) is causally associated with arteriosclerosis cardiovascular disease (ASCVD) risk. Whether ATP-sensitive potassium channels (KATP) variants predict the risk increased Apo (≥ 80 mg/dL) and related ASCVD remain less clear. We recruited 522 subjects elevated counterpart (< from South China to assess associations KATP (rs11046182, rs78148713, rs145456027 rs147265929) risks serum mg/dL), carotid artery stenosis (CAS) ≥ 50% new-onset ischemic stroke...
Abstract Context Lower serum concentration of apolipoprotein A-I (ApoA-I) is causally associated with heart failure (HF) risk. Adenosine triphosphate–sensitive potassium channels (KATP), as gating coupling vascular reactivity and metabolism ischemic protection, become a new potential target management for HF. The KATP gene sequence highly polymorphic has high degree genetic heterogeneity. Objective This work aimed to determine whether variants predict the risks decreased ApoA-I its related...