A5102978156- Bacteriophages and microbial interactions
- RNA and protein synthesis mechanisms
- Bacterial Genetics and Biotechnology
- Blood Pressure and Hypertension Studies
- Enzyme Structure and Function
- Renin-Angiotensin System Studies
- Perovskite Materials and Applications
- RNA Research and Splicing
- Cardiovascular Health and Risk Factors
- Organic Light-Emitting Diodes Research
- Cerebrovascular and Carotid Artery Diseases
- Hormonal Regulation and Hypertension
- DNA and Nucleic Acid Chemistry
- HIV/AIDS drug development and treatment
- Plant Virus Research Studies
- HIV Research and Treatment
- Heart Rate Variability and Autonomic Control
- Quantum Dots Synthesis And Properties
- Advanced biosensing and bioanalysis techniques
- Cardiovascular Function and Risk Factors
- Genomics and Chromatin Dynamics
- Viral gastroenteritis research and epidemiology
- Intracranial Aneurysms: Treatment and Complications
- Polyomavirus and related diseases
- Synthesis and pharmacology of benzodiazepine derivatives
University of Colorado Anschutz Medical Campus
2019-2024
Kailuan General Hospital
2012-2024
Xiamen University
2022-2023
Army Medical University
2023
Chongqing Medical University
2023
Second Affiliated Hospital of Chongqing Medical University
2023
Dalian Medical University
2023
Huazhong University of Science and Technology
2018-2022
Nanjing Agricultural University
2022
People's Hospital of Xinjiang Uygur Autonomous Region
2018-2021
Abstract Perovskite light‐emitting diodes (PeLEDs) are strong candidates for next‐generation display and lighting technologies due to their high color purity low‐cost solution‐processed fabrication. However, PeLEDs not superior commercial organic (OLEDs) in efficiency, as some key parameters affecting such the charge carrier transport light outcoupling usually overlooked well optimized. Here, ultrahigh‐efficiency green reported with quantum efficiencies surpassing a milestone of 30% by...
The potent HIV-1 capsid inhibitor GS-6207 is an investigational principal component of long-acting antiretroviral therapy. We found that inhibits by stabilizing and thereby preventing functional disassembly the shell in infected cells. X-ray crystallography, cryo-electron microscopy, hydrogen-deuterium exchange experiments revealed tightly binds two adjoining subunits promotes distal intra- inter-hexamer interactions stabilize curved lattice. In addition, interferes with binding to cellular...
Essential hypertension (EH) is a principal contributing factor in worldwide cardiovascular disease mortality. Although interventions that minimize environmental risk factors for EH are associated with reduced disease, such approaches limited individuals high genetic risk. In this study, we investigated possible associations between ACE2 polymorphisms and hypertension-related target organ damages south Xinjiang, China. Four hundred two hypertensive patients were enrolled as study participants...
Type 2 diabetes mellitus (T2D), rapidly increasing to epidemic proportions, globally escalates cardiovascular disease risk. Although intensive interventions and comprehensive management of environmental risks factors for T2D are associated with reduced disease, such approaches limited individuals high genetic In this study we investigated possible associations ACE2 polymorphisms in Uygur patients T2D. 275 272 non-diabetic were enrolled as participants. 14 genotyped by Matrix-assisted laser...
Abstract Group III–V semiconductor‐based microscale light‐emitting diode (micro‐LED) displays are recognized as one of the most promising display technologies with superhigh brightness and resolution, strong contrast, superlarge color gamut but currently suffer from low efficiency, production yield, high cost. Here, it is proposed to realize cost‐effective full‐color micro‐LED by using perovskite quantum dot LEDs (micro‐PeLEDs) emitters. Bright uniform red‐, green‐, blue‐emitting (RGB)...
ABSTRACT Herpes simplex virus 1 (HSV-1), the prototypic member of herpesviruses, employs a virally encoded molecular machine called terminase to package viral double-stranded DNA (dsDNA) genome into preformed protein shell. The contains large subunit that is thought cleave concatemeric during packaging initiation and completion each cycle supply energy process via ATP hydrolysis. We have determined X-ray structure C-terminal domain large-subunit pUL15 (pUL15C) from HSV-1. shows fold...
Many DNA viruses use powerful molecular motors to cleave concatemeric viral into genome-length units and package them preformed procapsid powered by ATP hydrolysis. Here we report the structures of DNA-packaging motor gp2 bacteriophage Sf6, which reveal a unique clade RecA-like ATPase domain an RNase H-like nuclease tethered regulatory linker domain, exhibiting strikingly distinct arrangement. The complexed with nucleotides reveal, at atomic detail, catalytic center embraced domain. activity...
Cardiovascular benefits by reversing environmental risks factors for essential hypertension (EH) and dyslipidemia could be weaken high genetic risk. We investigated possible associations between ACE2 polymorphisms in patients with EH.Four hundred two hypertensive were enrolled an EH group 233 normotensive individuals as control from the Xinjiang region of China. Fourteen genotyped Matrix-assisted laser desorption ionization time-of-flight mass spectrometry.Participants carrying T allele (TT...
Polydopamine coating significantly prevents N loss during the pyrolysis of g-C 3 5 . N-Doped carbon drives organics oxidation by electron-transfer between surface-activated PMS and organic contaminants.
Lead halide perovskite nanocrystals (NCs) have been the star material in lighting and displays owing to their excellent photoelectrical properties, but they not simultaneously realized high photoluminescence quantum yield (PLQY) stability. To solve this problem, we propose a perovskite/linear low-density polyethylene (perovskite/LLDPE) core/shell NC by synergistic role of pressure effect steric effect. Green CsPbBr3/LLDPE NCs with near-unity PLQY nonblinking behavior were synthesized through...
Abstract Quasi‐2D Dion‐Jacobson (DJ) perovskites are promising candidates for fabricating high‐performance blue‐emitting perovskite light‐emitting diodes (PeLEDs) because of their strong quantum/dielectric confinement and high stability. However, obtaining high‐efficiency blue PeLEDs based on DJ remains a major challenge. Herein, sky‐blue synthesized by using 1,8‐diamino‐3,6‐dioxaoctane as an organic diamine high‐quality films prepared incorporating poly(vinylidene fluoride‐ co...
In herpesviruses and many bacterial viruses, genome-packaging is a precisely mediated process fulfilled by virally encoded molecular machine called terminase that consists of two protein components: A DNA-recognition component defines the specificity for packaged DNA, catalytic provides energy packaging reaction hydrolyzing ATP. The docks onto portal complex embedded in single vertex preformed viral shell procapsid, pumps DNA into procapsid through conduit formed portal. Here we report 1.65...
Abstract The Mediator complex plays an essential and multi-faceted role in regulation of RNA polymerase II transcription all eukaryotes. Structural analysis yeast has provided understanding the conserved core its interaction with but failed to reveal structure Tail module that contains most subunits targeted by activators repressors. Here we present a molecular model mammalian ( Mus musculus ) Mediator, derived from 4.0 Å resolution cryo-EM map complex. reveals previously unresolved module,...
<title>Abstract</title> Aims Plants evolve with persistent core microbiomes that extend host functional repertoires, yet the assembly patterns and functions of these communities remain insufficiently understood, limiting their application in enhancing plant performance. Methods We investigated bacterial bulk soil, rhizosphere root endosphere various Cd-hyperaccumulators growing under controlled field conditions, identified microbes linked to key traits using 16S rRNA gene sequencing...
The Ran-binding protein 2 (RanBP2) is a vertebrate mosaic composed of four interspersed RanGTPase binding domains (RBDs), variable and species-specific zinc finger cluster domain, leucine-rich, cyclophilin, cyclophilin-like (CLD) domains. Functional mapping RanBP2 showed that the domains, CLD, between RBD1 RBD2, RBD3 RBD4, respectively, associate specifically with nuclear export receptor, CRM1/exportin-1, components 19 S regulatory particle 26 proteasome. Now, we report novel domain located...
A novel information encryption and decryption technology was demonstrated based on chemical conversion between perovskite nanocrystal films.
The natural product α-hydroxytropolones manicol and β-thujaplicinol inhibit replication of herpes simplex viruses 1 2 (HSV-1 HSV-2, respectively) at nontoxic concentrations. Because these were originally developed as divalent metal-sequestering inhibitors the ribonuclease H activity HIV-1 reverse transcriptase, likely target related HSV proteins nucleotidyltransferase (NTase) superfamily, which share an "RNase H-like" fold. One potential candidate is pUL15, a component viral terminase...
Many dsDNA viruses encode DNA-packaging terminases, each containing a nuclease domain that resolves concatemeric DNA into genome-length units. Terminase nucleases resemble the RNase H-superfamily nucleotidyltransferases in folds, and share two-metal-ion catalytic mechanism. Here we show residue K428 of bacteriophage terminase gp2 mediates binding metal cofactor Mg(2+). A K428A mutation allows visualization, at high resolution, ion mode with coupled-octahedral configuration active site,...
A new 3,7-dihydroxytropolone synthetic strategy provides access to a proposed natural product precursor and potent antiviral compounds.
Ideal cardiovascular health (CVH) is associated with reduced risk of cardiac and cerebral events. Arterial stiffness plays an important role in the progress events, but it unclear whether ideal CVH, particular, cumulative exposure to CVH (cumCVH), arterial stiffness. We examined association between cumCVH using data from Kailuan Study.The study cohort consisted 20,355 participants community-based cohort, whose mean follow-up period was 3.36 years since baseline (visit 3). CumCVH calculated...