A5101760939- Cardiovascular Health and Disease Prevention
- Cardiovascular Health and Risk Factors
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Blood Pressure and Hypertension Studies
- Birth, Development, and Health
- Liver Disease Diagnosis and Treatment
- Cardiovascular Disease and Adiposity
- Pregnancy and preeclampsia studies
- Gestational Diabetes Research and Management
- Nutritional Studies and Diet
- Heart Rate Variability and Autonomic Control
- Cardiovascular Function and Risk Factors
- Cerebrovascular and Carotid Artery Diseases
- Cardiac Health and Mental Health
- Health, Environment, Cognitive Aging
- Chronic Kidney Disease and Diabetes
- Heart rate and cardiovascular health
- Lipoproteins and Cardiovascular Health
- Diabetes Management and Education
- Atrial Fibrillation Management and Outcomes
- Cardiac Imaging and Diagnostics
- Diet, Metabolism, and Disease
- Alcohol Consumption and Health Effects
- Silicon Carbide Semiconductor Technologies
- Health disparities and outcomes
North China University of Science and Technology
2014-2025
Kailuan General Hospital
2016-2025
Sixth Affiliated Hospital of Sun Yat-sen University
2025
Sun Yat-sen University
2025
Wuhan Institute of Technology
2024
Guilin University of Electronic Technology
2023-2024
Bioscience (China)
2024
Fudan University
2023
Nankai University
2021-2022
Guangdong Province Women and Children Hospital
2014-2022
Background— The American Heart Association Committee recently developed definitions of “ideal,” “intermediate,” and “poor” cardiovascular health based on 7 disease (CVD) risk factors or behaviors. This study evaluated the prevalence “ideal” metrics from June 2006 to October 2007 in Kailuan cohort (n=101 510; age 18–98 years) northern China its relationship with 4-year CVD incidence. Methods Results— We used Cox proportional hazards regression calculate hazard ratios 95% confidence intervals...
The American Heart Association 2020 Strategic Impact Goals target an improvement in overall cardiovascular health, as assessed by 7 health metrics (smoking, body weight, physical activity, diet, plasma glucose level, cholesterol and blood pressure).To examine whether trajectories of over time, the score (CHS) 2006, 2008, 2010, are associated with subsequent risk CVD.The Kailuan study is a prospective, population-based that began 2006. cohort included 74 701 Chinese adults free myocardial...
OBJECTIVE To examine the change in fasting blood glucose (FBG) during repeated assessments over time and its potential impact on risk of developing myocardial infarction (MI). RESEARCH DESIGN AND METHODS This prospective cohort study included 68,297 participants without diabetes (mean age 49 years) who were free MI, stroke, cancer prior to or 2010 (baseline current analysis). FBG concentrations measured 2006, 2008, 2010. The trajectories 2006–2010, primary exposure study, identified by...
Previous studies has shown a significant relationship between baseline triglyceride-glucose (TyG) index and cardiovascular disease (CVD). However, the long-term effect of TyG incident CVD remains uncertain. This study aimed to investigate association cumulative risk CVD.
The association between long-term blood pressure (BP) patterns in community-dwelling adults and risk of intracerebral hemorrhage cerebral infarction is not well characterized. This prospective study included 79 385 participants, free stroke, myocardial infarction, cancer or before 2010 (baseline). Systolic BP trajectories were identified using latent mixture modeling with data from 2006, 2008, 2010. Incident cases occurred during to 2014, confirmed by review medical records, 3 physicians. We...
Resting heart rate (RHR) is a predictive risk factor of the development cardiovascular diseases, but its association with arterial hypertension has remained unclear. This study investigated relationship between RHR and new-onset (NOH) in an Asian population.The Kailuan prospective longitudinal cohort on factors or cerebrovascular events. Hazard ratios 95% confidence intervals (CIs) were calculated using Cox regression modelling.Out 101 510 individuals originally included into study, 31 507...
The association between vascular stiffening and blood pressure is likely bidirectional. present study was designed to examine temporal relationships among stiffness, progression, hypertension. Asymptomatic Polyvascular Abnormalities Community a community‐based, prospective, long‐term follow‐up observational study. investigation based on the baseline examinations (2010–2011) first measurements (2012–2013) included in A total of 4025 participants were followed for an average 27 months. Of 2153...
The persistence and clinical consequences of rabies virus (RABV) infection have prompted global efforts to develop a safe effective vaccines against rabies. mRNA represent promising option emerging re-emerging infectious diseases, gaining particular interest since the outbreak COVID-19. Herein, we report development highly efficacious vaccine composed sequence-modified encoding RABV glycoprotein (RABV-G) packaged in core-shell structured lipopolyplex (LPP) nanoparticles, named LPP-mRNA-G....
Background and Aims The American Heart Association has recently established seven ideal cardiovascular health metrics for promotion disease reduction (i.e., non-smoking, normal body mass index, physically active, healthy diet, levels of cholesterol, blood pressure fasting glucose). present study seeks to evaluate how well these predict mortality from all causes diseases in adult Chinese living a northern industrial city. Methods Results Data 95,429 adults who participated the Kailuan cohort...
<h3>Background</h3> Gait speed modulation is impaired in manifest Huntington's disease (mHD) due to reduced stride length. Speed impairments and their functional correlates have not been examined prodromal HD (pHD). <h3>Aims</h3> (1) To examine (stride length-cadence relationship) pHD mHD; (2) evaluate the association between mobility. <h3>Method</h3> We tested 20 (mean = 41.75 y), 19 mHD 44 controls 42.45 y). Experiment I (internal cues): subjects walked at self-selected preferred, fast,...
In 2010 the American Heart Association proposed a definition of ideal health behaviors and factors to measure cardiovascular health, from which Huffman et al. created Cardiovascular Health Score (CVH score) estimate these metrics on an individual level. We performed prospective cohort study among employees Kailuan Group Corporation, who underwent physical examination in 2006–2007 investigate relationship between CVH score risk disease (CVD). A total 91,598 individuals free stroke myocardial...
Abstract Objective We aimed to examine the association of triglyceride-glucose index (TyG) with risk for cardiovascular disease (CVD) among postmenopausal women. Methods A total 7741 participants met inclusion criteria, and were included in analysis. The TyG was calculated as ln (triglyceride [mg/dL] × fasting blood glucose [mg/dL]/2). classified into four groups by quartiles index, Q1 group used reference group. cumulative incidence CVD compared using Kaplan–Meier curves. between women...
Abstract Background The triglyceride–glucose index (TyG index), an alternative indicator of peripheral insulin resistance (IR), is associated with cardiovascular disease (CVD) in the general population. aim this research was to determine correlation between early-onset stroke and TyG among young Chinese adults. Methods Participants (age ≤ 40 years) who attended their first physical examination Kailuan General Hospital or its 11 subsidiary hospitals 2006 2012 were enrolled. subjects divided...
Background Resting heart rate (RHR) predicts both cardiovascular and noncardiovascular death in different populations. However, the results of association between RHR diseases (CVDs) are inconsistent, especially for each subtype CVDs. Objective The aim this study was to prospectively explore relationship CVDs including myocardial infarction (MI), ischemic stroke, hemorrhagic stroke all-cause a general population. Methods Kailuan is prospective longitudinal cohort on risk factors or...
Arterial stiffness (AS) was associated with heart failure (HF) in previous studies based on specific populations small samples and the effects of age blood pressure AS were not taken into account. Whether independently new-onset HF community dwellers has been fully investigated to date.Individuals who participated health evaluations underwent synchronized brachial-ankle pulse wave velocity (baPWV) screening 2010 2019 included. They free atrial fibrillation at baseline. The participants...
Multi-modality medical imaging study, especially brain MRI, greatly facilitates the research on subclinical disease. However, there is still a lack of such studies with wider age span participants. The MEdical sTudy bAsed KaiLuan Study (META-KLS) was designed to address this issue large sample size population. We aim enrol at least 1000 subjects in META-KLS. All participants without contraindications will perform multi-modality imaging, including retinal fundus photograph, optical coherence...
The triglyceride-glucose (TyG) index is considered as a pivotal factor for various metabolic, cardiovascular, and cerebrovascular diseases. However, there currently paucity of relevant studies on the association between long-term level change TyG-index cardiometabolic diseases (CMDs) risk. We aimed to explore risk CMDs in relation TyG-index.Based prospective cohort study, total 36359 subjects who were free CMDs, had complete data triglyceride (TG) fasting blood glucose (FBG) underwent four...
Abstract Background Ustekinumab (UST) has been proved to be effective in the treatment of Crohn's disease (CD). However, data on efficacy UST treating CD patients with penetrating complications are limited. The objective this study was evaluate and safety CD. Methods In single-center, prospective, observational real-world study, we enrolled who were undergoing treatment. primary endpoint rate transmural healing at week 26 52 evaluated by computerized tomography enterography or magnetic...
Abstract Hexagonal boron nitride (h-BN) has emerged as a promising two-dimensional material for quantum and optoelectronic applications, with its unique ability to host engineered defects enabling single-photon emission spin manipulation. This study investigates defect formation in h-BN using focused helium ion beam (He + FIB) irradiation post-annealing treatments. We demonstrate that at doses up 2×10 9 ions/μm 2 does not induce phase transitions or amorphization. Spectroscopic analyses,...