A5100428454- Nanoplatforms for cancer theranostics
- Immunotherapy and Immune Responses
- Nanoparticle-Based Drug Delivery
- Immune Cell Function and Interaction
- Cancer Immunotherapy and Biomarkers
- Advanced Nanomaterials in Catalysis
- RNA Interference and Gene Delivery
- Immune cells in cancer
- Gut microbiota and health
- MicroRNA in disease regulation
- Cancer, Hypoxia, and Metabolism
- Immune Response and Inflammation
- Spine and Intervertebral Disc Pathology
- Osteoarthritis Treatment and Mechanisms
- Extracellular vesicles in disease
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- SARS-CoV-2 and COVID-19 Research
- interferon and immune responses
- Cell Adhesion Molecules Research
- Hippo pathway signaling and YAP/TAZ
- Photoacoustic and Ultrasonic Imaging
- Advanced biosensing and bioanalysis techniques
- Antimicrobial Peptides and Activities
- Cancer Research and Treatments
Soochow University
2016-2025
Nanjing University
2018-2025
Nanjing Drum Tower Hospital
2018-2025
Fuzhou University
2024-2025
Deyang Stomatological Hospital
2025
Brown University
2015-2025
Rhode Island Hospital
2015-2025
Shanghai Clinical Research Center
2021-2025
Shanghai Institute of Hematology
2025
Shanghai Xuhui Central Hospital
2013-2025
Abstract A therapeutic strategy that can eliminate primary tumours, inhibit metastases, and prevent tumour relapses is developed herein by combining adjuvant nanoparticle-based photothermal therapy with checkpoint-blockade immunotherapy. Indocyanine green (ICG), a agent, imiquimod (R837), Toll-like-receptor-7 agonist, are co-encapsulated poly(lactic-co-glycolic) acid (PLGA). The formed PLGA-ICG-R837 nanoparticles composed purely three clinically approved components be used for near-infrared...
The Drosophila TEAD ortholog Scalloped is required for Yki-mediated overgrowth but largely dispensable normal tissue growth, suggesting that its mammalian counterpart may be exploited selective inhibition of oncogenic growth driven by YAP hyperactivation. Here we test this hypothesis genetically and pharmacologically. We show a dominant-negative molecule does not perturb liver potently suppresses hepatomegaly/tumorigenesis resulting from overexpression or Neurofibromin 2 (NF2)/Merlin...
We have previously shown that antimicrobial peptides like defensins the capacity to mobilize leukocytes in host defense. LL-37 is cleaved 37-residue, COOH-terminal peptide of hCAP18 (human cationic protein with a molecular size 18 kD), only identified member humans family proteins called cathelicidins. LL-37/hCAP18 produced by neutrophils and various epithelial cells. Here we report chemotactic for, can induce Ca(2+) mobilization in, human monocytes formyl receptor-like 1 (FPRL1)-transfected...
A unique type of pH/H2O2 dual-responsive intelligent nanoscale delivery system based on albumin-coated MnO2 is presented, which capable modulating the tumor microenvironment (TME) by relieving hypoxia. Additionally, TME-responsive size changes enable effective intratumor diffusion. highly combined photodynamic and chemotherapy realized with these nanoparticles in a mouse model. As service to our authors readers, this journal provides supporting information supplied authors. Such materials...
Tumor vaccines for cancer prevention and treatment have attracted tremendous interests in the area of immunotherapy recent years. In this work, we present a strategy to construct by encapsulating immune-adjuvant nanoparticles with cell membranes modified mannose. Poly(d,l-lactide-co-glycolide) are first loaded toll-like receptor 7 agonist, imiquimod (R837). Those adjuvant (NP-R) then coated (NP-R@M), whose surface proteins could act as tumor-specific antigens. With further modification...
External radiotherapy is extensively used in clinic to destruct tumors by locally applied ionizing-radiation beams. However, the efficacy of usually limited tumor hypoxia-associated radiation resistance. Moreover, as a local treatment technique, can hardly control metastases, major cause cancer death. Herein, core-shell nanoparticles based poly(lactic-co-glycolic) acid (PLGA) are fabricate, encapsulating water-soluble catalase (Cat), an enzyme that decompose H2 O2 generate , inside inner...
Hypoxia not only promotes tumor metastasis but also strengthens resistance to therapies that demand the involvement of oxygen, such as radiation therapy and photodynamic (PDT). Herein, taking advantage high reactivity manganese dioxide (MnO 2 ) nanoparticles toward endogenous hydrogen peroxide (H O within microenvironment generate , multifunctional chlorine e6 (Ce6) loaded MnO with surface polyethylene glycol (PEG) modification (Ce6@MnO ‐PEG) are formulated achieve enhanced tumor‐specific...
Hypoxia, a common feature within many types of solid tumors, is known to be closely associated with limited efficacy for cancer therapies, including radiotherapy (RT) in which oxygen essential promote radiation-induced cell damage. Here, an artificial nanoscale red-blood-cell system designed by encapsulating perfluorocarbon (PFC), commonly used blood substitute, biocompatible poly(d,l-lactide-co-glycolide) (PLGA), obtaining PFC@PLGA nanoparticles, are further coated membrane (RBCM). The...
Defensins, a family of cationic, structurally related, antimicrobial peptides, contribute to host defense by disrupting the cytoplasmic membrane microbes. Here we show that human neutrophil defensins selectively induce migration CD4+/CD45RA+ naive and CD8+, but not CD4+/CD45RO+ memory, T cells. Moreover, are chemotactic for immature dendritic cells derived from either CD34+ progenitors or peripheral blood monocytes. Upon maturation induced treatment with tumor necrosis factor alpha...
Significance Hydrogen peroxide is closely associated with many important physiological and pathological events. Herein, we develop a liposomal nanoprobe for in vivo H 2 O -responsive chromogenic assay, which highly specific sensitive to . Using such nanoprobe, photoacoustic imaging of -related inflammation processes mice induced by either LPS or bacteria realized. Meanwhile, reacting endogenous produced tumor cells, allows early-stage small tumors orthotopic brain glioma even enables...
Recently, graphene oxide (GO) based nanocomposites have raised significant interests in many different areas, one of which being antibacterial agents where sliver nanoparticle (AgNPs) anchored GO (GO-Ag) has shown promising potential. However, to our best knowledge, factors affecting its activity as well the underlying mechanism remain unclear. In this study, we fabricate GO-Ag with AgNPs ratios and carefully investigate their activities against both Gram-negative (G-) bacteria Escherichia...
Abstract Previous studies have demonstrated that β-defensins exhibit chemotactic activity by sharing the chemokine receptor CCR6 with CC ligand CCL20/macrophage-inflammatory protein-3α (MIP-3α). Structural analysis of CCL20/MIP-3α revealed most positively charged residues are concentrated at one area its topological surface, a characteristic considered to be important for antimicrobial defensins. Here, we report similar defensins, has effects on Escherichia coli, Pseudomonas aeruginosa,...
A new "Abraxane-like" nanotheranostic formulation self-assembled from three clinically approved agents, human serum albumin, paclitaxel, and indocyanine green, is developed. Utilizing such a newly formulated nanodrug, combined photothermal chemotherapy conducted under the guidance of imaging, not only effectively eliminating subcutaneous tumors, but also significantly inhibiting development metastatic tumors in this proof-of-concept study. As service to our authors readers, journal provides...
In recent years, a wide range of near-infrared (NIR) light absorbing nanomaterials, mostly inorganic ones, have been developed for photothermal therapy (PTT) cancer. this work, we develop novel organic PTT agent based on poly-(3,4-ethylenedioxythiophene):poly(4-styrenesulfonate) (PEDOT:PSS), conductive polymer mixture with strong NIR absorbance, in vivo treatment After being layer-by-layer coated charged polymers and then conjugated branched polyethylene glycol (PEG), the obtained...
Chimeric antigen receptor (CAR)-redirected T lymphocytes (CAR cells) show modest therapeutic efficacy in solid tumors. The desmoplastic structure of the tumor and immunosuppressive microenvironment usually account for reduced CAR cells Mild hyperthermia reduces its compact interstitial fluid pressure, increases blood perfusion, releases antigens, promotes recruitment endogenous immune cells. Therefore, combination mild with adoptive transfer can potentially increase index these It is found...
Abstract Reactive oxygen species (ROS) play vital roles in intestinal inflammation. Therefore, eliminating ROS the inflammatory site by antioxidant enzymes such as catalase and superoxide dismutase may effectively curb bowel disease (IBD). Here, Escherichia coli Nissle 1917 (ECN), a kind of oral probiotic, was genetically engineered to overexpress (ECN-pE) for treatment To improve bioavailability ECN-pE gastrointestinal tract, chitosan sodium alginate, effective biofilms, were used coat via...
Eosinophil-derived neurotoxin (EDN) is an eosinophil granule–derived secretory protein with ribonuclease and antiviral activity. We have previously shown that EDN can induce the migration maturation of dendritic cells (DCs). Here, we report activate myeloid DCs by triggering Toll-like receptor (TLR)2–myeloid differentiation factor 88 signaling pathway, thus establishing as endogenous ligand TLR2. activates TLR2 independently TLR1 or TLR6. When mice were immunized ovalbumin (OVA) together...
Paclitaxel (PTX) can bind to human serum albumin (HSA) via hydrophobic interaction, forming Abraxane, which is a U.S. Food and Drug Administration (FDA) approved effective antitumor nanomedicine drug. Herein, the drug PTX used induce self-assembly of HSA modified with either photosensitizer chlorin e6 (Ce6), at same time serves as chelating agent for Mn2+ enable magnetic resonance imaging, or acyclic Arg-Gly-Asp (cRGDyK) peptide that targets αvβ3-integrin overexpressed on tumor angiogenic...
YAP (Yes-associated protein) and TAZ (transcriptional coactivator with PDZ-binding motif) are major downstream effectors of the Hippo pathway that influences tissue homeostasis, organ size, cancer development. Aberrant hyperactivation YAP/TAZ causes overgrowth tumorigenesis, whereas their inactivation impairs development regeneration. Dynamic precise control activity is thus important to ensure proper physiological regulation homeostasis cells. Here, we show activation results in negative...