A5045355006- CAR-T cell therapy research
- Immunotherapy and Immune Responses
- Nanowire Synthesis and Applications
- Advanced Breast Cancer Therapies
- Viral Infectious Diseases and Gene Expression in Insects
- Cancer-related cognitive impairment studies
- Virus-based gene therapy research
- Nanoparticle-Based Drug Delivery
- Nanofabrication and Lithography Techniques
- Nanoplatforms for cancer theranostics
- HER2/EGFR in Cancer Research
- RNA Interference and Gene Delivery
- Advancements in Semiconductor Devices and Circuit Design
- Advanced biosensing and bioanalysis techniques
- Neuroscience and Neural Engineering
- Cancer Immunotherapy and Biomarkers
- Extracellular vesicles in disease
- Graphene and Nanomaterials Applications
University of North Carolina at Chapel Hill
2019-2025
North Carolina State University
2019-2021
UNC Lineberger Comprehensive Cancer Center
2019-2021
Chimeric antigen receptor (CAR)-redirected T lymphocytes (CAR cells) show modest therapeutic efficacy in solid tumors. The desmoplastic structure of the tumor and immunosuppressive microenvironment usually account for reduced CAR cells Mild hyperthermia reduces its compact interstitial fluid pressure, increases blood perfusion, releases antigens, promotes recruitment endogenous immune cells. Therefore, combination mild with adoptive transfer can potentially increase index these It is found...
Chimeric antigen receptor T cell (CAR T) therapy was a milestone in the treatment of relapsed and refractory B malignancies. However, beneficial effects CAR cells have not been obtained solid tumors yet. Herein, we implement porous microneedle patch that accommodates allows situ penetration-mediated seeding when implanted tumor bed or post-surgical resection cavity. loaded pores tips were readily escorted to an evenly scattered manner without losing their activity. Such microneedle-mediated...
Regional delivery of chimeric antigen receptor (CAR) T cells in glioblastoma represents a rational therapeutic approach as an alternative to intravenous administration avoid the blood-brain barrier impediment. Here, we developed fibrin gel that accommodates CAR-T cell loading and promotes their gradual release. Using model subtotal resection, demonstrated fibrin-based within surgical cavity enables superior antitumor activity compared directly inoculated into tumor resection cavity.
Advances in the development of therapeutic extracellular vesicles (EVs) for cancer immunotherapy have allowed them to emerge as an alternative cell therapy. In this proof-of-concept work, we develop bispecific EVs (BsEVs) by genetically engineering EV-producing dendritic cells (DCs) with aCD19 scFv and PD1 targeting tumor antigens blocking immune checkpoint proteins simultaneously. We find that these (EVs-PD1-aCD19) impressive ability accumulate huCD19-expressing solid tumors following...
PHOTOTHERMAL THERAPYCAR-T lymphocytes show modest therapeutic efficacy in solid tumors.Mild hyperthermia of the tumor reduces its compact structure and interstitial fluid pressure (IFP), increases blood perfusion, releases antigens, promotes recruitment endogenous immune cells.In article number 1900192, Gianpietro Dotti, Zhen Gu, co-workers find that CSPG4-specific CAR-T cells infused NSG mice engrafted with human melanoma WM115 cell line had superior antitumor activity after photothermal...
Abstract Chimeric antigen receptor T (CAR‐T) cell therapy has produced impressive clinical responses in patients with B‐cell malignancies. Critical to the success of CAR‐T therapies is achievement robust gene transfer into cells mediated by viral vectors such as gamma‐retroviral vectors. However, current methodologies retroviral rely on spinoculation and use retronectin, which may limit implementation cost‐effective therapies. Herein, a low‐cost, tunable, macroporous, alginate scaffold that...
Abstract Chimeric antigen receptor (CAR)‐modified T‐cell therapy has shown enormous clinical promise against blood cancers, yet efficacy solid tumors remains a challenge. Here, we investigated the potential of new combination cell therapy, where tumor‐homing induced neural stem cells (iNSCs) are used to enhance CAR‐T‐cell and achieve efficacious suppression brain tumors. Using in vitro vivo migration assays, found iNSC‐secreted RANTES/IL‐15 increased sixfold expansion threefold, resulting...
Drug delivery systems based on amphiphilic supramolecular macrocycles have garnered increased attention over the past two decades due to their ability successfully formulate nanoparticles. Macrocyclic (MC) materials can self-assemble at lower concentrations without need for surfactants and polymers, but are required form stabilize nanoparticles higher concentrations. Using MCs deliver both hydrophilic hydrophobic guest molecules is advantageous. We developed novel types of macrocycle (MC...
Drug delivery systems based on amphiphilic supramolecular macrocycles have garnered increased attention over the past two decades due to their ability successfully formulate nanoparticles. Macrocyclic (MC) materials can self-assemble at lower concentrations without need for surfactants and polymers, but are required form stabilize nanoparticles higher concentrations. Using MCs deliver both hydrophilic hydrophobic guest molecules is advantageous. We developed novel types of macrocycle (MC...