A5076072879- Immunotherapy and Immune Responses
- Extracellular vesicles in disease
- Nanoplatforms for cancer theranostics
- Immune cells in cancer
- CAR-T cell therapy research
- Nanoparticles: synthesis and applications
- Cancer Immunotherapy and Biomarkers
- Cancer Research and Treatments
- Cancer, Hypoxia, and Metabolism
- Vitamin C and Antioxidants Research
- Neuroblastoma Research and Treatments
- Berberine and alkaloids research
- Tissue Engineering and Regenerative Medicine
- Rheumatoid Arthritis Research and Therapies
- Bone Tissue Engineering Materials
- Natural product bioactivities and synthesis
- 3D Printing in Biomedical Research
- COVID-19 Impact on Reproduction
- Bone and Dental Protein Studies
- Carbon and Quantum Dots Applications
- Cancer Cells and Metastasis
- Complement system in diseases
- Ginseng Biological Effects and Applications
- Pharmacological Effects of Natural Compounds
- Periodontal Regeneration and Treatments
Soochow University
2020-2023
Autoimmune diseases are the third most common disease influencing quality of life many patients. Here, a programmed cell death-ligand 1 + (PD-L1) mesenchymal stem (MSC) derived extracellular vesicles (MSC-sEVs-PD-L1) using lentivirus-mediated gene transfection technology is developed for reconfiguration local immune microenvironment affected tissue in autoimmune diseases. MSC-sEVs-PD-L1 exhibits an impressive ability to regulate various activated cells immunosuppressed state vitro. More...
Abstract Microbe-based cancer immunotherapy has recently emerged as a hot topic for treatment. However, serious limitations remain including infection associated side-effect and unsatisfactory outcomes in clinic trials. Here, we fabricate different sizes of nano-formulations derived from yeast cell wall (YCW NPs) by differential centrifugation. The induction anticancer immunity our formulations appears to inversely correlate with their size due the ability accumulate tumor-draining lymph...
An implantable blood clot–based cancer vaccine is developed for enhanced immunotherapy.
Cancer vaccine platform has attracted great interest in the field of cancer immunotherapy. Here, 3D printed scaffolds loaded with immunoregulators are developed for enhanced The rapid manufacturing and precise molding based on printing can realize mass vaccines personalized design. Meanwhile, compared to traditional hydrogel, 3D-scaffold porous structure endows its similar functions real lymphoid organs by recruitment a number immune cells, leading formation "artificial tertiary structures,"...
The treatment of large-area bone defects still faces many difficulties and challenges. Here, we developed a blood clot delivery platform loaded with BMP-2 protein ([email protected]) for enhanced regeneration. Blood gel as natural biomaterials can be engineered from autologous blood. Once implanted into the large defect site, it used local delivery, well modulating osteoimmunology by recruiting great number macrophages regulating their polarization at different stages. Moreover, due to...
Immune checkpoint blockade (ICB) therapy has been considered as an effective way to boost immune cells recognize and attack tumors. However, side effects known immune-related adverse events (irAEs) should be carefully managed. Here, we engineer immunosuppressive nanoparticles by coating PD-L1 overexpressed mesenchymal stem (MSCs) plasma membrane on poly lactic-co-glycolic acid (MSC-PD-L1+ NPs) for managing reducing irAEs induced inhibitors. The can enrich at liver site after intravenous...
Advances in the development of therapeutic extracellular vesicles (EVs) for cancer immunotherapy have allowed them to emerge as an alternative cell therapy. In this proof-of-concept work, we develop bispecific EVs (BsEVs) by genetically engineering EV-producing dendritic cells (DCs) with aCD19 scFv and PD1 targeting tumor antigens blocking immune checkpoint proteins simultaneously. We find that these (EVs-PD1-aCD19) impressive ability accumulate huCD19-expressing solid tumors following...
Owing to the immune microenvironment of bones and low selectivity drug, patients with bone metastases often respond poorly immunotherapy. In this study, programmed cell death protein 1 (PD1)-expressing hematopoietic stem cells (HSCs) are genetically engineered for bone-targeted delivery transforming growth factor beta (TGF-β) small-molecule inhibitor SB-505124 (SB@HSCs-PD-1). Intriguingly, compared anti-PD-L1 monoclonal antibodies, as "living drugs", HSCs-PD-1 not only show great targeting...
Platelet extracellular vesicles are engineered to deliver dexamethasone in acute pneumonia. This drug delivery system considerably reduces the anxiety-like behavior and calms down cytokine storm compared mice treated with free drug.
Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized by inflammation and joint destruction. Herein, an inflamed joint‐targeting delivery platform developed based on platelet‐derived extracellular vesicles (PEVs) that are naturally occurring nanoparticles released platelets, loaded with berberine (BBR) for suppressing the progress of RA. It found PEVs could selectively target site in RA mice. In addition, BBR‐loaded exert anti‐inflammatory effects reshaping inflammatory...
Rheumatoid arthritis (RA) is a systemic autoimmune disease with clinical manifestations including joint cartilage, synovitis, and bone damage. Here we developed an injectable erythrocyte gel loaded Bulleyaconitine A (BLA) for the treatment of RA demonstrated its anti-inflammatory effects in vivo vitro. In vitro experiments showed that BLA could effectively down-regulate expression pro-inflammatory factor activated macrophages through nuclear factor-κB (NF-κB) pathway. have shown injection...
Adv. NanoBiomed Res. 2021, 2100071 DOI: 10.1002/anbr.202100071 In the initially published version of this article, following equal contribution statement referring to authors Qingle Ma and Jinyu Bai was omitted from author section: Q.M. J.B. contributed equally work.
Implanted biomaterials have transformed healthcare and the treatment of injury disease, but their influence on local immune landscape remains unclear. Here we discovered that degradation-resistant titanium-based implants establish an immunosuppressive microenvironment by recruiting myeloid cells, including monocytes, macrophages, neutrophils, myeloid-lineage dendritic cells. Unlike normal tissues, tissues nearby exhibit chronic inflamed status characterised myeloid-rich, T cell-exhaustion...
Cancer Immunotherapy In article number 2106768, Chao Wang and co-workers develop a 3D-printed scaffold loaded with immunoregulators for enhanced cancer immunotherapy. The 3D-scaffold porous structure endows the system similar functions to real lymphoid organs by recruitment of large immune cells, leading formation “artificial tertiary structures” (aTLS), which are promising sites enhance both humoral cellular responses. Efficient anticancer immunity is induced when combined checkpoint...
Abstract Background and Aims Nanoplastics (NPs) as contaminants in food water have drawn an increasing public attention. However, little is known about how NPs shape the gut immune landscape after entering body. The objective of study was to explore indirect effects caused by interaction with mammalian whole system Methods In this study, we fabricated (∼500 nm) microplastics (MPs) (∼2 μm) aimed evaluate their vivo feeding them mice. mechanism then investigated various technology including...