A5041437278- Fatty Acid Research and Health
- Eicosanoids and Hypertension Pharmacology
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Alcohol Consumption and Health Effects
- Diet, Metabolism, and Disease
- Lipid metabolism and disorders
- Cardiovascular Function and Risk Factors
- Peroxisome Proliferator-Activated Receptors
- Liver Disease Diagnosis and Treatment
- Cholesterol and Lipid Metabolism
- Cardiovascular Disease and Adiposity
- Adipose Tissue and Metabolism
- Nuts composition and effects
- Diet and metabolism studies
- Lipid metabolism and biosynthesis
- Sleep and related disorders
- Metabolomics and Mass Spectrometry Studies
- Cardiovascular Health and Risk Factors
- Lipoproteins and Cardiovascular Health
- Renal Diseases and Glomerulopathies
- Cancer, Lipids, and Metabolism
- Diabetes Management and Research
- Antiplatelet Therapy and Cardiovascular Diseases
- Nutritional Studies and Diet
- Inflammatory mediators and NSAID effects
Pennsylvania State University
2016-2025
University of South Dakota
2011-2024
Sanford Research
2010-2024
DEVCOM Army Research Laboratory
2017-2021
New York University
2021
United States Army
2021
ICF International (United Kingdom)
2019-2021
Drexel University
2021
St. Gregory's University
2013-2019
Sanford USD Medical Center
2013
Diets rich in fermentable fibres provide an array of health benefits; however, many patients with IBD report poor tolerance to fibre-rich foods. Intervention studies dietary murine models colonic inflammation have yielded conflicting results on whether ameliorate or exacerbate IBD. Herein, we examined how replacing the insoluble fibre, cellulose, fibres, inulin pectin, impacted colitis resulting from immune dysregulation via inhibition interleukin (IL)-10 signalling and/or innate deficiency...
Background— Omega-3 polyunsaturated fatty acids (eicosapentaenoic acid and docosahexaenoic acid) from fish oil ameliorate cardiovascular diseases. However, little is known about the effects of ω-3 on cardiac fibrosis, a major cause diastolic dysfunction heart failure. The present study assessed fibrosis. Methods Results— We left ventricular fibrosis pathology in mice subjected to transverse aortic constriction after consumption or control diet. In mice, 4 weeks induced significant...
A subject's baseline FA composition may influence the ability of dietary highly unsaturated omega-3 FAs (n3-HUFA) to change circulating profiles esterified and their oxygenated metabolites. This study evaluates basal n3-HUFA n3-oxylipin status on magnitude response consumption. Blood was collected from fasting subjects (n = 30) before after treatment (4 weeks; 11 ± 2 mg/kg/day ethyl esters). Esterified were quantified in erythrocytes, platelets, plasma by GC-MS. oxylipins LC-MS/MS. Treatment...
The long-chain omega-3 fatty acids (n-3 FA) eicosapentaenoic acid (EPA) and docosahexaenoic (DHA) have beneficial health effects, but the molecular mediators of these effects are not well characterized. Oxygenated n-3 FAs (oxylipins) may be an important class mediators. Members this chemical include epoxides, alcohols, diols, ketones, many which bioactivity in vitro. Neither presence oxylipins human plasma nor effect FA ingestion on their levels has been documented. We measured derived from...
High density lipoprotein (HDL) cholesterol levels are associated with decreased risk of cardiovascular disease, but not all HDL functionally equivalent. A primary determinant functional status is the conformational adaptability its main protein component, apoA-I, an exchangeable apolipoprotein. Chemical modification as may occur under conditions inflammation or diabetes, can severely impair function and presence disease. apoA-I also impairs ability to exchange on off HDL, a critical process...
Heart failure with preserved ejection fraction (HFpEF) is half of all HF, but standard HF therapies are ineffective. Diastolic dysfunction, often secondary to interstitial fibrosis, common in HFpEF. Previously, we found that supra-physiologic levels ω3-PUFAs produced by 12 weeks ω3-dietary supplementation prevented fibrosis and contractile dysfunction following pressure overload [transverse aortic constriction (TAC)], a model resembles aspects remodeling This raised several questions...
Objectives: The objective of this study is to outline a framework for how fatty acids may be acting as mediators/suppressors and/or moderators an individual’s genetic predisposition cardiovascular lipid biomarkers. Methods: All UK Biobank participants with demographic and lifestyle variables, circulating lipids, NMR-measured acid data collected at the baseline visit (N = 229,859) were included in analyses. We fit four separate linear regression models, one each following common measures...
Background Assessment of coronary heart disease (CHD) risk is typically based on a weighted combination standard factors. We sought to determine the extent which lipidomic approach red blood cell fatty acid (RBC-FA) profiles could discriminate acute syndrome (ACS) cases from controls, and compare RBC-FA discrimination with that Methodology/Principal Findings were measured in 668 ACS 680 age-, race- gender-matched controls. Multivariable logistic regression models FA (FA) factors (SRF)...
Objective The purpose of this study was to compare the apolipoprotein composition three major lipoprotein classes in patients with metabolic syndrome healthy controls. Methods Very low density (VLDL), intermediate/low (IDL/LDL, hereafter LDL), and high lipoproteins (HDL) fractions were isolated from plasma 56 subjects 14 age-sex matched volunteers. content analyzed by one-dimensional (1D) gel electrophoresis confirmation a combination mass spectrometry biochemical assays. Results Metabolic...
Metabolic syndrome (MetSyn) is characterized by chronic inflammation which mediates the associated high risk for cardiovascular and other diseases. Oxylipins are a superclass of lipid mediators with potent bioactivities in inflammation, vascular biology, more. While their role as locally produced agents appreciated, most oxylipins plasma found lipoproteins suggesting defective regulation could be mediated elevated VLDL low HDL levels characteristic MetSyn. Our objective was to compare...