A5015038886- Fatty Acid Research and Health
- Nutritional Studies and Diet
- Eicosanoids and Hypertension Pharmacology
- Diet and metabolism studies
- Cardiovascular Health and Disease Prevention
- Phytochemicals and Antioxidant Activities
- Blood Pressure and Hypertension Studies
- Heart Rate Variability and Autonomic Control
- Diet, Metabolism, and Disease
- Lipid metabolism and disorders
- Adipokines, Inflammation, and Metabolic Diseases
- Obesity, Physical Activity, Diet
- Antioxidant Activity and Oxidative Stress
- Consumer Attitudes and Food Labeling
- Pharmacology and Obesity Treatment
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Immune Response and Inflammation
- Birth, Development, and Health
- Stress Responses and Cortisol
- Natural Antidiabetic Agents Studies
- Sleep and related disorders
- Traumatic Brain Injury Research
- Metabolomics and Mass Spectrometry Studies
- Alcohol Consumption and Health Effects
- Phytoestrogen effects and research
University of Arizona
2017-2023
Pennsylvania State University
2008-2020
University of Wisconsin–Madison
2017
Park University
2016
Office of Dietary Supplements
2012
National Institutes of Health
2012
Allegheny College
2011
University of Massachusetts Chan Medical School
2007-2009
Hypertriglyceridemia (triglycerides 200-499 mg/dL) is relatively common in the United States, whereas more severe triglyceride elevations (very high triglycerides, ≥500 are far less frequently observed. Both becoming increasingly prevalent States and elsewhere, likely driven large part by growing rates of obesity diabetes mellitus. In a 2002 American Heart Association scientific statement, omega-3 fatty acids (n-3 FAs) eicosapentaenoic acid (EPA) docosahexaenoic (DHA) were recommended (at...
The erythrocyte membrane content of eicosapentaenoic acid (EPA) and docosahexaenoic (DHA), which constitutes the omega-3 index (O3I), predicts cardiovascular disease mortality. amount EPA+DHA needed to achieve a target O3I is poorly defined, as are determinants response change in intake. objective this study was develop predictive model supplementation healthy adults, specifically identifying factors that determine response.A randomized, placebo-controlled, double-blind, parallel-group...
The consumption of cocoa and dark chocolate is associated with a lower risk CVD, improvements in endothelial function may mediate this relationship. Less known about the effects cocoa/chocolate on augmentation index (AI), measure vascular stiffness tone peripheral arterioles. We enrolled thirty middle-aged, overweight adults randomised, placebo-controlled, 4-week, cross-over study. During active treatment (cocoa) period, participants consumed 37 g/d sugar-free beverage (total = 22 g/d, total...
Endothelial dysfunction is an important outcome for assessing vascular health in intervention studies. However, reliability of the standard non-invasive method (flow-mediated dilation) a significant challenge clinical applications and multicenter trials. We evaluated repeatability pulse amplitude tonometry (PAT) to measure change wave during reactive hyperemia (Itamar Medical Ltd, Caesarea, Israel). Twenty healthy adults completed two PAT tests (mean interval = 19.5 days) under standardized...
Despite the importance of n-3 fatty acids for health, intakes remain below recommended levels. The objective this study was to provide an updated assessment fish and acid intake (i.e., eicosapentaenoic (EPA), docosahexaenoic (DHA), EPA+DHA) in United States using 2003–2014 National Health Nutrition Examination Survey (NHANES) data (n = 45,347)). Over survey period, toddlers, children, adolescents (aged 1–19) had significantly lower (p < 0.001) compared adults seniors, which remained...
Background Walnuts have beneficial effects on cardiovascular risk factors, but it is unclear whether these are attributable to the fatty acid ( FA ) content, including α‐linolenic ALA ), and/or bioactives. Methods and Results A randomized, controlled, 3‐period, crossover, feeding trial was conducted in individuals at for disease (n=45). Following a 2‐week standard Western diet run‐in (12% saturated FAs [ SFA ], 7% polyunsaturated FAs, 12% monounsaturated FAs), participants consumed 3...
Specialized pro-resolving mediator(s) (SPMs) are produced from the endogenous ω-3 polyunsaturated fatty acids (PUFA), eicosapentaenoic acid (EPA) and docosahexaenoic (DHA), accelerate resolution of acute inflammation. We identified specific clusters SPM in human plasma serum using LC-MS/MS based lipid mediator (LM) metabololipidomics two separate laboratories for inter-laboratory validation. The cluster consisted resolvin (Rv)E1, RvD1, lipoxin (LX)B4, 18-HEPE, 17-HDHA, RvE1, AT-LXA4,...
Abstract The American Heart Association recommends consuming fish (particularly oily fish) at least two times per week, which would provide ≈ 0.5 g/day of eicosapentaenoic acid (EPA) + docosahexaenoic (DHA) for cardiovascular disease risk reduction. Previous analyses indicate that this recommendation is not being met; however, few studies have assessed different ethnicities, subpopulations requiring additional n‐3 fatty intake (i.e., children and pregnant and/or lactating women), or deciles...
Despite the popularity of dietary nitrate supplementation and growing evidence base its potential ergogenic vascular health benefits, there is no direct information about effects on exercising limb blood flow in humans. We hypothesized that acute from beetroot juice would augment increases forearm flow, as well progressive dilation brachial artery, during graded handgrip exercise healthy young men. In a randomized, double-blind, placebo-controlled crossover study, 12 (22 ± 2 years) men...
The role of the long-chain omega-3 (n-3) fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic (DHA) in lipid metabolism inflammation has been extensively studied; however, little is known about relationship between docosapentaenoic (DPA, 22:5 n-3) triglycerides (TG). We evaluated whether n-3 DPA content red blood cells (RBC) was associated with markers (interleukin-6 (IL-6), tumor necrosis factor α (TNF-α), C-reactive protein (CRP) fasting TG prior to supplementation two studies...
Although there are many recognized health benefits for the consumption of omega-3 (n-3) long-chain polyunsaturated fatty acids (LCPUFA), intake in United States remains below recommended amounts. This analysis was designed to provide an updated assessment fish and n-3 LCPUFA (eicosapentaenoic (EPA), docosahexaenoic acid (DHA), EPA+DHA) adult population, based on education, income, race/ethnicity, using data from 2003-2014 National Health Nutrition Examination Survey (NHANES) (n = 44,585)....
Ajulemic acid (AjA), a synthetic nonpsychoactive cannabinoid, and lipoxin A(4) (LXA(4)), an eicosanoid formed from sequential actions of 5- 15-lipoxygenases (LOX), facilitate resolution inflammation. The purpose this study was to determine whether the ability AjA limit progress inflammation might relate increase in LXA(4), known anti-inflammatory proresolving mediator. Addition (0-30 microM) vitro human blood synovial cells increased production LXA(4) (ELISA) 2- 5-fold. Administration mice...
Abstract Little is known about transient effects of foods and nutrients on reactivity to mental stress. In a randomized crossover study healthy adults ( n = 20), we measured heart rate variability (respiratory sinus arrhythmia), blood pressure, other hemodynamic variables after three test meals varying in type amount fat. Measurements were collected at rest during speech cold pressor tasks. There significant postmeal changes resting diastolic pressure (−4%), cardiac output (+18%), total...
Data suggest that culinary spices are a potent, low-calorie modality for improving physiological responses to high fat meals. In pilot study (N = 6 healthy adults), we showed meal containing antioxidant spice blend attenuated postprandial lipemia by 30% compared low meal. Our goal was confirm this effect in larger sample and consider the influence of acute psychological stress on metabolism. Further, used vitro methods evaluate inhibitory digestive enzymes. 2 x 2, randomized, 4-period...