A5088399069- Heart Failure Treatment and Management
- Synthesis and Reactivity of Sulfur-Containing Compounds
- Cardiovascular Function and Risk Factors
- Organophosphorus compounds synthesis
- Synthesis of heterocyclic compounds
- Sulfur-Based Synthesis Techniques
- Sepsis Diagnosis and Treatment
- Phosphorus compounds and reactions
- Synthesis and Catalytic Reactions
- Acute Myocardial Infarction Research
- Cardiac Arrest and Resuscitation
- Atrial Fibrillation Management and Outcomes
- Organic Chemistry Cycloaddition Reactions
- Synthesis and Characterization of Heterocyclic Compounds
- Cardiac electrophysiology and arrhythmias
- Cyclopropane Reaction Mechanisms
- Cardiac pacing and defibrillation studies
- Hormonal Regulation and Hypertension
- Cardiac Fibrosis and Remodeling
- Synthesis of Organic Compounds
- Liver Disease Diagnosis and Treatment
- Cardiac Imaging and Diagnostics
- Biomarkers in Disease Mechanisms
- Carbohydrate Chemistry and Synthesis
- Asymmetric Synthesis and Catalysis
Roche (Switzerland)
2019-2024
Massachusetts General Hospital
2023
Harvard University
2023
Mario Negri Institute for Pharmacological Research
2012-2021
Istituti di Ricovero e Cura a Carattere Scientifico
1996-2021
Hospital de Sant Pau
2021
Istituto Nazionale di Fisica Nucleare, Sezione di Milano
2020
Ospedale Maggiore
2004-2015
Mario Negri Sud Foundation
2007-2015
Associazione Nazionale Medici Cardiologi Ospedalieri
2000-2015
Although previous studies have suggested the potential advantages of albumin administration in patients with severe sepsis, its efficacy has not been fully established.In this multicenter, open-label trial, we randomly assigned 1818 100 intensive care units (ICUs), to receive either 20% and crystalloid solution or alone. In group, target serum concentration was 30 g per liter more until discharge from ICU 28 days after randomization. The primary outcome death any cause at days. Secondary...
Neurohormones are considered markers of heart failure progression. We examined whether changes in brain natriuretic peptide (BNP) and norepinephrine (NE) over time associated with corresponding mortality morbidity the Valsartan Heart Failure Trial.Plasma BNP NE were measured before randomization during follow-up approximately 4300 patients Trial. The relation between baseline all-cause first morbid event (M&M) was analyzed subgroups, values above below median, by quartiles. change percent...
Circulating cardiac troponin T, a marker of cardiomyocyte injury, predicts adverse outcome in patients with heart failure (HF) but is detectable only small fraction those chronic stable HF. We assessed the prognostic value circulating T HF traditional (cTnT) and new precommercial highly sensitive assay (hsTnT).Plasma was measured 4053 enrolled Valsartan Heart Failure Trial (Val-HeFT). Troponin 10.4% population cTnT (detection limit < or = 0.01 ng/mL) compared 92.0% hsTnT (< 0.001 ng/mL)....
Background— The role of C-reactive protein (CRP) in heart failure is not well studied. We assessed the prognostic value CRP patients randomized Val-HeFT (Valsartan Heart Failure Trial) and studied changes that were associated with valsartan. Methods Results— Characteristics baseline levels above below median compared. Univariable multivariable Cox proportional hazards regression models used to examine relationship mortality morbidity. Interactions tested determine whether differences from 4...
Background: The B-type or brain natriuretic peptides (BNP) and the amino-terminal probrain peptide (NT-proBNP) are good markers of prognosis diagnosis in chronic heart failure (HF). It is unclear, however, whether differences their biological characteristics modify clinical correlates prognostic performance HF. This work aimed to provide a direct comparison value BNP NT-proBNP patients with stable Methods: We measured at baseline 3916 enrolled Valsartan Heart Failure Trial. To identify...
Rationale: Unphysiologic strain (the ratio between tidal volume and functional residual capacity) stress transpulmonary pressure) can cause ventilator-induced lung damage.Objectives: To identify a strain–stress threshold (if any) above which damage occur.Methods: Twenty-nine healthy pigs were mechanically ventilated for 54 hours with producing 0.45 3.30. Ventilator-induced was defined as net increase in weight.Measurements Main Results: Initial weight capacity measured computed tomography....
Objective: Tidal volume (VT) and of gas caused by positive end-expiratory pressure (VPEEP) generate dynamic static lung strains, respectively. Our aim was to clarify whether different combinations resulting in the same large global strain, constantly produce edema. Design: Laboratory investigation. Setting: Animal unit. Subjects: Twenty-eight healthy pigs. Interventions: After computed tomography, 20 animals were ventilated for 54 hours at a strain 2.5, either entirely (VT 100% VPEEP 0%),...
Abstract Introduction Sepsis, a leading cause of death in critically ill patients, is the result complex interactions between infecting microorganisms and host responses that influence clinical outcomes. We evaluated prognostic value presepsin (sCD14-ST), novel biomarker bacterial infection, compared it with procalcitonin (PCT). Methods This retrospective, case–control study multicenter, randomized trial enrolling patients severe sepsis or septic shock ICUs Italy. selected 50 survivors...
Background— Brain natriuretic peptide (BNP) and norepinephrine (NE) are strongly related to severity of independent predictors outcome in heart failure. The long-term effects angiotensin receptor blockers on BNP NE failure patients not known. Methods Results— Both were measured 4284 randomized valsartan or placebo the Valsartan Heart Failure Trial (Val-HeFT) at baseline 4, 12, 24 months after randomization. tested by ANCOVA, controlling for values concomitant ACE inhibitors and/or...
Cardiac troponins are emerging as important prognostic markers in chronic cardiovascular conditions like stable coronary artery disease or heart failure (HF). Less is known about the relation between serial measurements of high-sensitivity cardiac troponin T (hs-cTnT) and future events HF. We determined association changes over time hs-cTnT outcome patients with HF.We analyzed 5284 HF from 2 independent randomized clinical trials, Valsartan Heart Failure Trial (Val-HeFT) (n=4053) Gruppo...
Both reduced glomerular filtration and increased urinary albumin excretion independently determine outcome in patients with chronic heart failure (HF). However, tubulo-interstitial injury might indicate renal damage, even the presence of normal filtration. We studied relationship between tubular filtration, excretion, HF patients. In 2130 participating GISSI-HF trial, we measured albumin-to-creatinine ratio (UACR), estimated rate (eGFR), three markers damage: N-acetyl-beta-d-glucosaminidase...
Abstract Septic shock remains a major problem in Intensive Care Unit, with high lethality and high-risk second lines treatments. In this preliminary retrospective investigation we examined plasma metabolome clinical features subset of 20 patients severe septic (SOFA score >8), enrolled the multicenter Albumin Italian Outcome Sepsis study (ALBIOS, NCT00707122). Our purpose was to evaluate changes circulating metabolites relation mortality as pilot be extended larger cohort. Patients were...
Background— We developed a prognostic model to assess the risk of all-cause mortality in patients with chronic heart failure. Methods and Results— examined 6975 failure enrolled Gruppo Italiano per lo Studio della Streptochinasi nell'Infarto Miocardico-Heart Failure (GISSI-HF) trial (3.9 years follow-up). Multivariable Cox regression models were predict (1969 deaths). By stepwise selection, full final included 25 predictors. A reduced model, considering most significant variables ranked...
The renin-angiotensin system (RAS) plays a role in the pathogenesis of ARDS, Angiotensin II (Ang-II) contributing to inflammation and fibrogenesis. Angiotensin-(1-7) (Ang-(1-7)) may antagonize effects Ang-II. This study was aimed at evaluating potential for Ang-(1-7) reduce injury, fibrosis an experimental model ARDS acute late phases.Male Sprague Dawley rats underwent instillation 0.1 M hydrochloric acid (HCl, 2.5 ml/kg) into right bronchus. In study, acid-injured were subjected high...