A5058033856- Breast Lesions and Carcinomas
- Ovarian cancer diagnosis and treatment
- Breast Cancer Treatment Studies
- Pelvic floor disorders treatments
- Palliative Care and End-of-Life Issues
- Endometriosis Research and Treatment
- Endometrial and Cervical Cancer Treatments
- Cancer and Skin Lesions
- Gynecological conditions and treatments
- Respiratory Support and Mechanisms
- Breast Implant and Reconstruction
- Cancer Diagnosis and Treatment
- Decision-Making and Behavioral Economics
- Uterine Myomas and Treatments
- Menopause: Health Impacts and Treatments
- Anorectal Disease Treatments and Outcomes
- Urinary Bladder and Prostate Research
- Thyroid Cancer Diagnosis and Treatment
- Reconstructive Surgery and Microvascular Techniques
- Cancer survivorship and care
- Financial Markets and Investment Strategies
- Geriatric Care and Nursing Homes
- Neonatal Respiratory Health Research
- Soft tissue tumor case studies
- Management, Economics, and Public Policy
National University of Rosario
2025
Sapienza University of Rome
2015-2024
Policlinico Umberto I
2014-2024
IBM (Italy)
2014-2022
University of Florence
2021
Fondazione Humanitas per la Ricerca
1990-2020
Università Campus Bio-Medico
2019
AbbVie (United States)
2017
Vita-Salute San Raffaele University
2014-2016
University of Milan
1993-2015
Objective: Tidal volume (VT) and of gas caused by positive end-expiratory pressure (VPEEP) generate dynamic static lung strains, respectively. Our aim was to clarify whether different combinations resulting in the same large global strain, constantly produce edema. Design: Laboratory investigation. Setting: Animal unit. Subjects: Twenty-eight healthy pigs. Interventions: After computed tomography, 20 animals were ventilated for 54 hours at a strain 2.5, either entirely (VT 100% VPEEP 0%),...
The objective of this study was to evaluate the impact delirium on survival advanced cancer patients also assessed with a validated prognostic score (the palliative [PaP] score).The population prospective multicenter consecutive case series for whom chemotherapy no longer considered viable and who were referred care programs. Clinical biologic factors included in PaP at entry. Confusion Assessment Method criteria applied screen presenting delirium. Survival times measured from time...
High tidal volume can cause ventilator-induced lung injury (VILI), but positive end-expiratory pressure (PEEP) is thought to be protective. We aimed find the volumetric VILI threshold and see whether PEEP protective per se or indirectly. In 76 pigs (22 ± 2 kg), we examined lower upper limits (30.9–59.7 mL/kg) of inspiratory capacity by computed tomography (CT) scan at 45 cmH2O pressure. The underwent a 54-h mechanical ventilation with global strain ((tidal (dynamic) + (static))/functional...
Improving the prognosis of breast cancer patients is utmost importance in terms increasing survival rates. Modern medicine has therefore prioritized better quality life for patients, even after disease, through a management potential long-term side effects induced by anticancer treatments. Fertility preservation and family planning are crucial issues to be addressed all reproductive age. Along those lines, new branch with distinct multidisciplinary characteristics developed over years:...
<h3>Objective.</h3> —To assess prospectively the impact on survival and health-related quality of life two follow-up protocols in patients with early breast cancer. <h3>Design.</h3> —Randomized controlled clinical trial. <h3>Setting.</h3> —Multicenter study involving 26 general hospitals Italy. <h3>Patients.</h3> —A consecutive sample 1320 women younger than 70 years stage I, II, III unilateral primary <h3>Intervention.</h3> —Patients were randomly assigned to an intensive surveillance,...
Background: Adipose tissue is a source of stromal and vascular cells suitable for regenerative medical applications. Cell recovery depends on several factors, including the characteristics cannula used to harvest tissue. Objectives: The authors assess whether aspiration superficial layers adipose performed with microcannula, rather than standard cannula, allows improved isolation cells, they evaluate angiogenic potential isolated in vitro vivo. Methods: Adipose-derived stem (ADSC) were...
Triple negative breast cancer (TNBC) has an aggressive clinical behaviour, with a poorer prognosis compared to other subtypes. Recently, tumor-infiltrating lymphocytes (TILs) have been proposed as predictive biomarker for better outcome and pathological response (pR) after neoadjuvant chemotherapy (NACT) in TNBC. These data confirm the role of immune system neoplastic progression therapy. We performed retrospective analysis 54 pre-NACT biopsies TNBC both percentage stromal TILs degree PD-L1...
Background Several factors influence patients' trust, and trust influences the doctor-patient relationship. Recent literature has investigated quality of personal relationship its dynamics by considering role communication elements that giving in frame general practitioner (GP) consultations. Objective We analysed certain aspects interaction between patients GPs to understand formation maintenance focusing on channels. The impact socio-demographic variables relationships was also evaluated....
OBJECTIVE: To investigate the relations between acute inflammation, as shown by high C‐reactive protein (CRP) serum levels, and laboratory indexes of iron nutritional status to ascertain whether presence inflammation affects diagnostic reliability these indexes. DESIGN: Cross‐sectional study. SETTING: Geriatric ward for rehabilitation. PARTICIPANTS: A total 163 patients, 77 men 86 women aged 60 years or older. MEASUREMENTS: CRP values > 1 mg/dL were considered indicate inflammation. Iron...
Abstract Introduction Hepatic mitochondrial dysfunction may play a critical role in the pathogenesis of metformin-induced lactic acidosis. However, patients with severe metformin intoxication have 30 to 60% decrease their global oxygen consumption, as for generalized inhibition respiration. We developed pig model validate this clinical finding and assess function liver other tissues. Methods Twenty healthy pigs were sedated mechanically ventilated. Ten infused large dose (4 8 g) five not...