A5037596194- Dementia and Cognitive Impairment Research
- Alzheimer's disease research and treatments
- COVID-19 Clinical Research Studies
- SARS-CoV-2 detection and testing
- SARS-CoV-2 and COVID-19 Research
- Health disparities and outcomes
- Health, Environment, Cognitive Aging
- Frailty in Older Adults
- Hemoglobinopathies and Related Disorders
- Blood Pressure and Hypertension Studies
- Blood transfusion and management
- Lipoproteins and Cardiovascular Health
- Health Systems, Economic Evaluations, Quality of Life
- Renal Diseases and Glomerulopathies
- Aging and Gerontology Research
- Aging, Health, and Disability
- Neuroinflammation and Neurodegeneration Mechanisms
- Research on Leishmaniasis Studies
- Balance, Gait, and Falls Prevention
- COVID-19 epidemiological studies
- Blood donation and transfusion practices
- COVID-19 diagnosis using AI
- Blood groups and transfusion
- Health and Medical Research Impacts
- S100 Proteins and Annexins
Instituto de Investigaciones Científicas y Servicios de Alta Tecnología
2015-2025
Secretaría Nacional de Ciencia, Tecnología e Innovación
2019-2025
City of Knowledge
2015-2024
Acharya Nagarjuna University
2014-2016
Abstract The last decade has seen a substantial increase in research focused on the identification of blood‐based biomarkers that have utility Alzheimer's disease (AD). Blood‐based significant advantages being time‐ and cost‐efficient as well reduced invasiveness increased patient acceptance. Despite these efforts, field been hampered by lack reproducibility an unclear path for moving basic discovery toward clinical utilization. Here we reviewed recent literature AD to provide current state...
This study combined data across four independent cohorts to examine the positive and negative predictive values of an Alzheimer's disease (AD) blood test if implemented in primary care.
La acumulación irregular de la proteína ?-amiloide (A?), tau hiperfosforilada y neuroinflamación son factores que afectan función neuronal en Enfermedad Alzheimer (EA). asociada a EA podría causar el daño sináptico por sí mismo o exacerbar causado A?. Se ha detectado un aumento citocina CCL1 (I-309) suero sangre periférica personas con Deterioro Cognitivo Leve (DCL) EA, lo se propone puede ser útil como biomarcador diagnóstico del DCL EA. El objetivo general este estudio fue evaluar efecto...
To describe the biomarker profiles in elderly Panamanians diagnosed with Alzheimer's disease (AD), mild cognitive impairment (MCI) or no using serum-based biomarkers.Twenty-four proteins were analyzed an electrochemiluminescence-based multiplex assay platform. A profile was generated random forest analyses.Two differed among groups: IL-18 and T-lymphocyte-secreted protein I-309. The AD highly accurate independent of age, gender, education Apolipoprotein E ε4 status. MCI had substantial...
Cognitive impairment and depression are common mental health problems among the elderly, although few studies have examined their cooccurrence in older adults Latin America. The purpose of this study was to examine cognitive impairment, depression, two conditions associated factors a sample Panama. This included 304 community-dwelling elderly (≥ 65 years) individuals. Participants underwent clinical interview assessments function by Minimental State Examination depressive symptoms Geriatric...
Novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the etiologic agent of ongoing disease 2019 (COVID-19) pandemic, which has reached 28 million cases worldwide in 1 year. The serological detection antibodies against virus will play a pivotal role complementing molecular tests to improve diagnostic accuracy, contact tracing, vaccine efficacy testing, and seroprevalence surveillance. Here, we aimed first evaluate lateral flow assay's ability identify specific IgM IgG...
Abstract Background At the beginning of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) pandemic, transfusion disease 2019 (COVID‐19) convalescent plasma (CCP) emerged as a potential therapeutic strategy to help patients severely afflicted by COVID‐19. The efficacy CCP has been controversial it depends on many variables pertaining donor and patient with COVID‐19, for example, time convalescence or symptoms onset. This feasibility descriptive study aimed assess safety multiple...
Background Evidence suggests that a combination of biological and social factors influence risk dementia differently for women men. In healthy older women, several may contribute to changes in cognition. Objective Describe the characteristics associated with variation cognition sample cognitively Panamanian women. Methods The study includes cross-sectional analyses cognitive domains at baseline ( n = 357) 17-month (SD 2.0) follow-up 200) aged 60 years enrolled Panama Aging Research...
Falls are common among elderly adults, and predictors of hospitalization, institutionalization mortality.
Research on age-related cognitive impairment is scarce in Central America. We report factors associated with among a sample of older adults Panama diagnosed Alzheimer's disease (AD, n = 31), mild (MCI, 43), or no (controls, 185). Apolipoprotein E (ApoE) genotype was assessed subset cases (n 135). Age (OR 2.53, 95% CI 1.03-6.17) and ApoE ɛ4 5.14, 2.11-12.52) were significantly related to (AD/MCI combined). Results underscore the potential genetic screening for identifying those at risk dementia.
COVID-19 is the name of acute respiratory disease caused by new coronavirus SARS-CoV-2, a close relative those that severe outbreaks SARS and MERS several years ago. Since first appearance on December 2019, pandemic has cause extremely high levels mortality, morbidity, global economic breakdown, consequent human suffering. The main diagnostic test for confirmation symptomatic individuals detection viral RNA reverse transcriptase-quantitative real time PCR (RT-PCR). Additionally, serology...
Summary The adequate choice of Trypanosoma cruzi strains as antigen source for the diagnosis Chagas disease is still controversial due to differences in terms accuracy reported between different diagnostic tests. In this study was determined if genetic variability genotypes T. (TcI, Tc II and IV ) affect final disease. sensitivity specificity index in‐house ELISA tests prepared with were evaluated chagasic non‐chagasic control sera using TESA ‐blot a reference test. results revealed that did...
The Panama Aging Research Initiative is a cohort study of 423 adults aged ≥65 years recruited from an outpatient geriatric department Panama’s largest public hospital, the Social Security Fund’s Dr Arnulfo Arias Madrid Hospital Complex (Complejo Hospitalario de la Caja Seguro Social). provides first reports modifiable and non-modifiable risk factors cognitive impairment dementia, as well various health conditions common among older in Panama, including chronic illnesses, polypharmacy rates...
Vascular pathology and genetic markers such as apolipoprotein E allele ε4 (ApoE ε4) are risk factors for the progression from mild cognitive impairment (MCI) to Alzheimer's disease (AD). In Panama, a high prevalence of vascular an increase in aging population, generate need investigate biomarkers using specific, sensitive, non-invasive cost-efficient methods that could be used primary care. The main objective this study was explore association between intima-media thickness (IMT) stenosis,...
Abstract A rapidly aging world population is fueling a concomitant increase in Alzheimer's disease (AD) and related dementias (ADRD). Scientific inquiry, however, has largely focused on White populations Australia, the European Union, North America. As such, there an incomplete understanding of AD other populations. In this perspective, we describe research efforts challenges cohort studies from three regions world: Central America, East Africa, Asia. These cohorts are engaging with Davos...
ABSTRACT Novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the etiologic agent of ongoing disease 2019 (COVID-19) pandemic, which has reached 28 million cases worldwide in eight months. The serological detection antibodies against virus will play a pivotal role complementing molecular tests to improve diagnostic accuracy, contact tracing, vaccine efficacy testing and seroprevalence surveillance. Here, we aimed first evaluate lateral flow assay’s ability identify specific...
Early in the SARS-CoV-2 pandemic, many national public health authorities implemented non-pharmaceutical interventions to mitigate disease outbreaks. Panamá established mandatory mask use two months after its first documented case. Initial compliance was high, but diverse masks were used areas. We studied behavioral dynamics of through COVID-19 waves Panama, improve implementation effective, low-cost containment measures when populations are exposed novel air-borne pathogens. Mask behavior...
Background: A growing body of evidence points to potential risks associated with polypharmacy (using ≥5 medications) in older adults, but most is derived from studies where racial and ethnic minorities remain underrepresented among research participants. Objective: Investigate the association between cognitive function, subjective health state, frailty, falls Hispanic adults. Methods: Panama Aging Research Initiative–Health Disparities (PARI-HD) a community-based cohort study adults free...
The population of Hispanic older adults is growing along with the burden chronic diseases. This cross-sectional study aims to assess factors associated frailty among community-dwelling women aged ≥60 years ( n = 357) enrolled in Panama Aging Research Initiative—Health Disparities cognitive-functional health persons Panama. Cognitive function was assessed a neuropsychological test battery. Depression measured Geriatric Scale. Frailty defined using Fried criteria and participants were...
Abstract Background Dementia affects nearly 50 million people worldwide and is the leading cause of disability in older adults. According to predictions by World Health Organization, global population with dementia will reach 82 2030, 152 2050. Currently, pharmacological interventions delay cognitive decline are proving be insufficient. By contrast, non‐pharmacological approaches have gained attention recent years because they can improve clinical symptoms, low risk could even alleviate...