A5100437318- Pain Mechanisms and Treatments
- Nitric Oxide and Endothelin Effects
- Ion channel regulation and function
- Geology and Paleoclimatology Research
- Acupuncture Treatment Research Studies
- Intellectual Property and Patents
- Innovation Policy and R&D
- Neuropeptides and Animal Physiology
- Climate variability and models
- Arctic and Antarctic ice dynamics
- Cryospheric studies and observations
- Adenosine and Purinergic Signaling
- Electromagnetic Fields and Biological Effects
- Nanoplatforms for cancer theranostics
- Electrospun Nanofibers in Biomedical Applications
- Geological formations and processes
- Neuroscience and Neuropharmacology Research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Economic Growth and Productivity
- Protein Kinase Regulation and GTPase Signaling
- Climate change and permafrost
- Laser Applications in Dentistry and Medicine
- Cancer, Hypoxia, and Metabolism
- Neuroinflammation and Neurodegeneration Mechanisms
- Nerve injury and regeneration
Chinese Academy of Sciences
2002-2025
Shenzhen Institutes of Advanced Technology
2025
Dalian Institute of Chemical Physics
2023
Institute of Tibetan Plateau Research
2023
Lanzhou University
2022
Institute of Biophysics
2008-2021
National Research Institute of Brewing
2019
Shanghai Xuhui Central Hospital
2017
Shanghai Clinical Research Center
2017
Peking University
2014
Sonodynamic therapy (SDT) is a promising therapeutic modality known for its non-invasiveness, temporal-spatial controllability, and deeper tissue penetration. However, the SDT treatment efficacy still hampered by scarcity of ideal sonosensitizers complex tumor microenvironment (TME). To address these challenges, sono-metabolic nano-composite (TiO2-Au@DON) using metabolic reprogramming prodrugs 6-Diazo-5-oxo-l-norleucine (DON) grafted on TiO2-Au Janus nanoparticles (NPs) fabricated. The...
Abstract Peripheral axotomy‐induced sprouting of thick myelinated afferents (A‐fibers) from laminae III–IV into I–II the spinal cord is a well‐established hypothesis for structural basis neuropathic pain. However, we show here that cholera toxin B subunit (CTB), neuronal tracer used to demonstrate A‐fibers in several earlier studies, also labels unmyelinated (C‐fibers) lamina II and thin I, when applied after peripheral nerve transection. The contained vasoactive intestinal polypeptide...
cGMP is considered the only mediator synthesized by soluble guanylyl cyclase (sGC) in response to nitric oxide (NO). However, purified sGC can synthesize several other cyclic nucleotides, including inosine 3',5'-cyclic monophosphate (cIMP). The present study was designed determine role of cIMP hypoxic contractions isolated porcine coronary arteries. Vascular responses were examined measuring isometric tension. Cyclic nucleotides assayed HPLC tandem mass spectroscopy. Rho kinase (ROCK)...
Novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the etiologic agent of ongoing disease 2019 (COVID-19) pandemic, which has reached 28 million cases worldwide in 1 year. The serological detection antibodies against virus will play a pivotal role complementing molecular tests to improve diagnostic accuracy, contact tracing, vaccine efficacy testing, and seroprevalence surveillance. Here, we aimed first evaluate lateral flow assay's ability identify specific IgM IgG...
Hollow smooth muscle organs such as the bladder undergo significant changes in wall tension associated with filling and distension, attendant tone. Our previous study indicated that stretch induces Ca(2+) release occurs form of sparks waves urinary myocytes. While, mechanism underlying stretch-induced Ca2+ is unknown.We examined transduction linking cell to release. The probability frequency induced by were closely related extent extension time was maintained. Experiments tissues single...
ABSTRACT The stretching of smooth muscle tissue modulates contraction through augmentation Ca2+ transients, but the mechanism underlying stretch-induced transients is still unknown. We found that mechanical and maintenance mouse urinary bladder strips single myocytes at 30% 18% beyond initial length, respectively, resulted in oscillations. Experiments indicated remarkably increased production nitric oxide (NO) as well amplitude duration contraction. Stretch-induced oscillations contractility...
Hatched from natural geomagnetic conditions, 1-day-old chicks were stimulated with Methyl Anthranilate (MeA) and labeled as the control group (CG). We found that line density of dendritic spines (LDds) neurons in memory-related nuclei [Intermediate Medial Hyperstriatum Ventrale (IMHV) lobus parolfactorius (LPO)] was increased by 38.7%, total lengths (TLds) individual IMHV 37.1 to 45.4%. In addition, average LDds imprinted (ICs) 10.8%, had long dendrites 50%. contrast, experimental...
Abstract Skeletal muscle contributes significantly to human health, which is closely relevant locomotion, energy metabolism, immune regulation, and aging. holds the potential recover its healthy condition via self‐repairing after minor damage. However, capacity of sarcous self‐repair becomes incompetent following massive trauma or some myopathy, raises a huge demand for skeletal regeneration. engineering aims rebuild tissues in vitro repair injuries, develop pathological models, advance...
Summary The Asian Pain Symposium (APS) is a main pain research meeting in Asia. Since established 2000 Kyoto, five other APSs have been held different regions including Seoul of Korea 2004, Fukuoka Japan 2008, Shanghai China 2011, Okazaki 2013, and Suzhou 2015. 7 th (APS 2017) was Taipei Taiwan during October 26th to 29th, 2017. APS 2017 sponsored by Ministry Science Technology Institute Biomedical Neuroscience Program Academia Sinica Society. president the Dr. Bai Chuang Shyu, Sciences,...