A5100324181- Ion channel regulation and function
- Calcium signaling and nucleotide metabolism
- Physiological and biochemical adaptations
- Neurobiology and Insect Physiology Research
- Cardiac electrophysiology and arrhythmias
- Cellular transport and secretion
- Salivary Gland Disorders and Functions
- Nitric Oxide and Endothelin Effects
- Insect and Arachnid Ecology and Behavior
- Diet and metabolism studies
- Cholesterol and Lipid Metabolism
- Lysosomal Storage Disorders Research
- Vitamin K Research Studies
- Atrial Fibrillation Management and Outcomes
- Cardiomyopathy and Myosin Studies
- Animal Genetics and Reproduction
- Ion Transport and Channel Regulation
- Integrated Energy Systems Optimization
- Salivary Gland Tumors Diagnosis and Treatment
- Vietnamese History and Culture Studies
- Hormonal Regulation and Hypertension
- Chinese history and philosophy
- Pluripotent Stem Cells Research
- Stress Responses and Cortisol
- Endoplasmic Reticulum Stress and Disease
Hebei University of Technology
2024
Chinese Academy of Sciences
2008-2018
Institute of Zoology
2015-2018
State Key Laboratory of Integrated Management of Pest Insects and Rodents
2018
Shanghai Jiao Tong University
2017
Ruijin Hospital
2017
Institute of Biophysics
2008-2016
Institute of Genetics and Developmental Biology
2016
Yangzhou University
2016
Guangxi Medical University
2012
This experiment was conducted to study the effects of dietary alfalfa flavonoids extraction supplemental level on growth performance, organ development and blood biochemical indexes Yangzhou geese at age 28 70 days. Two hundred forty 21-day-old healthy male with similar body weight were randomly distributed into 4 groups 6 replicates per group 10 replicate. Geese in control fed a basal diet others experimental (groups 1, 2, 3) diets supplemented 150, 300 450 mg/kg (the concentration it 81%),...
Chinese cordyceps, also known as “Dong Chong Xia Cao” in Chinese, which means being worm winter and herb summer, is the fruiting body of Ophiocordyceps sinensis developed from cadaver mum...
Introduction: Chronic social isolation (CSI) stress leads to numerous maladaptive changes in physiology and psychology, however, very little is known about the effects of longer time-scale CSI there are divergent views regarding underlying mechanisms. This study aimed elucidate common neuroendocrine mechanisms caused by 14-week (14wk-) 20-week (20wk-) CSI. Methods: We investigated impacts 14wk- 20wk- on anxiety/depression-like behaviors male C57BL/6N mice with classical behavioral tests,...
Information about the interactions of single nucleotide polymorphisms (SNPs) and overweight/obesity on serum lipid profiles is still scarce. The present study was undertaken to detect ten SNPs their with levels. A total 978 normal weight 751 overweight/obese subjects Bai Ku Yao were randomly selected from our previous stratified randomized cluster samples. Normal weight, overweight obesity defined as a body mass index (BMI) < 24, 24–28, > 28 kg/m2; respectively. Serum cholesterol (TC),...
Some Shanghai Clinical Center f a role of Niemann-Pick type C1 (NPC1) for obesity traits. However, whether the loss-of-function mutations in NPC1 cause adiposity humans remains unknown. We recruited 25 probands with rare autosomal-recessive C (NP-C) disease and their parents assessment effect heterozygous on adiposity. found that male NPC1+/- carriers had significantly higher BMI than matched control subjects or whole population-based subjects. Consistently, mice increased fat storage while...
Beta-adrenergic augmentation of Ca(2+) sparks and cardiac contractility has been functionally linked to phosphorylation-dependent dissociation FK506 binding protein 12.6 (FKBP12.6) regulatory proteins from ryanodine receptors subtype 2 (RYR2). We used FKBP12.6 null mice test the extent which affects mediates inotropic action isoproterenol (ISO), investigate underlying mechanisms cyclic ADP-ribose (cADPR) regulation sparks.Ca(2+) were measured in cardiomyocytes papillary muscle segments mice,...
Little is known about the interactions of single nucleotide polymorphisms (SNPs) and overweight/obesity on blood pressure levels. The present study was undertaken to detect 10 lipid-related gene SNPs their with Genotyping ATP-binding cassette transporter A1 (ABCA-1) V825I, acyl-CoA:cholesterol acyltransferase-1 (ACAT-1) rs1044925, low density lipoprotein receptor (LDL-R) AvaII hepatic lipase (LIPC) -250G > A, endothelial (LIPG) 584C T, methylenetetrahydrofolate reductase (MTHFR) 677C E3...
ABSTRACT The stretching of smooth muscle tissue modulates contraction through augmentation Ca2+ transients, but the mechanism underlying stretch-induced transients is still unknown. We found that mechanical and maintenance mouse urinary bladder strips single myocytes at 30% 18% beyond initial length, respectively, resulted in oscillations. Experiments indicated remarkably increased production nitric oxide (NO) as well amplitude duration contraction. Stretch-induced oscillations contractility...
The present study investigated whether dl-praeruptorin (Pd-Ia) prevents endothelin-1 (ET-1)-induced cardiomyocyte hypertrophy and the potential pathways that underlie such an effect. We assessed surface area, protein synthesis, expression of Bax/Bcl2 Jun genes, atrial natriuretic factor (ANF) Ca2+/calmodulin-dependent kinase II (CaMK-II) activity in cultured neonatal rat ventricular cardiomyocytes with ET-1-induced hypertrophy. It was found Pd-Ia decreased area synthesis rate exposed to...
Abstract Background Niemann-pick C1-like 1 (NPC1L1) is a key protein for intestinal cholesterol transportation. Common single nucleotide polymorphisms (SNPs) in the NPC1L1 gene have been associated with absorption and serum lipid levels. The present study was undertaken to explore possible association of rs2072183 1735 C > G SNP several environmental factors levels Mulao Han populations. Methods Genotyping performed 688 subjects 738 participants Chinese. interactions between polymorphism...
Abstract Ghost moths inhabiting the alpine meadows of Tibetan Plateau are cold‐adapted stenothermal organisms that susceptible to heat (dead within 7 days at 27 °C exposure). Exploring metabolic basis their susceptibility would extend our understanding thermal biology alpine‐dwelling invertebrates. Here, gas chromatography–mass spectrometry‐based metabolomics was combined with physiological and transcriptional approaches determine mechanisms in Thitarodes xiaojinensis larvae. The results...
Cardiomyocytes derived from murine embryonic stem (ES) cells possess various membrane currents and signaling cascades link to that of hearts. The role atrial natriuretic peptide (ANP) in regulation potentials Ca(2+) has not been investigated developmental cardiomyocytes.We the ANP regulating L-type channel current (I(CaL)) different stages cardiomyocytes ES cells. decreased frequency action (APs) early stage (EDS) cardiomyocytes, bodies (EB) as well whole embryo exerted an inhibitory effect...
Telomeres are maintained usually by telomerase, a specialized reverse transcriptase that adds this sequence to chromosome ends. In study, telomerase activity was detected in the different somatic tissues, such as midgut and fat bodies, telomeric repeat amplification protocol (TRAP) Spodoptera exigua. The structure of telomeres S. exigua evaluated analysis TRAP products, revealing synthesized (TTAGG)n repeat. presence (TERT) subunit coding gene has been cloned, sequenced expressed vitro...
Fully grown oocytes of most vertebrates are arrested at prophase I meiosis (G2 arrest). Upon exposure to steroid hormones, resume meiotic process, also called G2/M transition. The G protein-signaling pathway has been shown play essential roles in the arrest G2 phase. Previously, we showed that long chain fatty acyl-coenzyme A synthetase acsl1b was required for maintaining Xenopus Acsl1b presumably synthesizes palmitoyl-coenzyme can be utilized by acyltransferases modify proteins arrest. In...
This work is designed to study the thermodynamic equations of groundwater source heat pump in hot summer and cold winter, determine optimal operating conditions by means analysis pump, flow, unit, power, evaporation side condensation side. Practice has proved that equipment runs stably with high efficiency. By comparison, ground exchangers were compared conventional chillers boiler. The results showed underground had higher energy consumption, lower primary reduced CO2 emissions,...