A5101859547- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Cancer-related gene regulation
- RNA Research and Splicing
- Online Learning and Analytics
- COVID-19 Clinical Research Studies
- Online and Blended Learning
- Esophageal Cancer Research and Treatment
- Plant Molecular Biology Research
- Glycosylation and Glycoproteins Research
- Folate and B Vitamins Research
- Ferroptosis and cancer prognosis
- Metabolism, Diabetes, and Cancer
- Esophageal and GI Pathology
- Nutrition and Health in Aging
- Rabies epidemiology and control
- Epigenetics and DNA Methylation
- Mycobacterium research and diagnosis
- Gastrointestinal motility and disorders
- Renin-Angiotensin System Studies
- Advanced Neural Network Applications
- Chromosomal and Genetic Variations
- Insect-Plant Interactions and Control
Chinese Academy of Medical Sciences & Peking Union Medical College
2022-2025
Jiangsu Province Hospital
2022-2023
First Affiliated Hospital of Anhui Medical University
2023
Anhui Medical University
2023
Nanjing Medical University
2016-2023
The Seventh Affiliated Hospital of Sun Yat-sen University
2020-2023
Sun Yat-sen University
2020-2023
Central University of Finance and Economics
2022
State Key Laboratory of Oral Diseases
2018-2021
Sichuan University
2018-2021
ABSTRACT TLS, the product of a gene commonly translocated in liposarcomas (TLS), is prototypical newly identified class nuclear proteins that contain C-terminal domain with distinct RNA recognition motif (RRM) surrounded by Arg-Gly-Gly (RGG) repeats. Its unique N terminus serves as an essential transforming for number fusion oncoproteins human sarcomas and leukemias. In this study we use vivo UV crosslinking procedure to probe interactions TLS RNA. found bind association rapidly diminished...
A novel method for simultaneous segmentation of multiple interacting surfaces belonging to objects, called LOGISMOS (layered optimal graph image objects and surfaces), is reported. The approach based on the algorithmic incorporation spatial inter-relationships in a single n-dimensional graph, followed by optimization that yields globally solution. method's utility performance are demonstrated bone cartilage task human knee joint. Although trained only relatively small number nine example...
AbstractThe current discourse surrounding Massive Open Online Courses (MOOCs) is powerful. Despite their rapid and widespread deployment, research has yet to confirm or refute some of the bold claims rationalizing popularity efficacy these large-scale virtual learning environments. Also, MOOCs' reputed disruptive, game-changing potential for education remains unsubstantiated. A sober counterbalance needed, in particular, via attending students' everyday accounts complex realities massive...
Electroacupuncture (EA) at ST36 can significantly improve gastrointestinal symptoms, especially in promoting motility. The automatic nervous system plays a main role EA, but few studies exist on how vagovagal and sympathetic reflexes affect EA to regulate motility.To study the of ST36, as well associated receptor subtypes that are involved.Gastric motility was measured with manometric balloon placed gastric antrum area anesthetized animals. peripheral discharge using platinum electrode...
BackgroundGroup B Streptococcus is a common vaginal bacterium and the leading cause of invasive fetoplacental infections. Group in vagina can invade through cervix to ascending uteroplacental infections or be transmitted neonate during delivery. Some studies have found that women with "dysbiotic" polymicrobial Lactobacillus-depleted microbiota are more likely harbor group Streptococcus. Gardnerella vaginalis often most abundant bacteria vaginas dysbiosis, while being detected at lower levels...
An elevated level of homocysteine (Hcy) in the blood is designated hyperhomocysteinaemia (Hhcy) and regarded as a strong risk factor for development atherosclerosis (ATH), although association remains controversial. Considered to be essential gene expression regulators, micro-RNAs (miRNAs) modulate cardiovascular disease thus can potential biomarkers therapeutic targets atherosclerosis. The aim current study investigate levels atherosclerosis-associated miR-143 miR-145 Hhcy patients predict...
Delays in diagnosis and treatment initiation may allow the emergence of new cases by transmission to community, is one challenges facing programme management drug resistance Myanmar. This study aimed explore delays initiation, associated factors among patients with multidrug-resistant tuberculosis. A cross-sectional was conducted at Yangon Regional Tuberculosis Centre, Data were collected face-to-face interviews treatment-card reviews all adult who had registered started standard regimen...
The TLS-CHOP oncoprotein, found in the majority of human myxoid liposarcomas, consists a fusion between transcription factor CHOP/GADD153 and N terminus an RNA-binding protein TLS/FUS. Clinical correlation vitro transformation assays indicate that TLS plays important role oncogenesis by TLS-CHOP. Until now, however, only activity attributed to oncoprotein is inhibiting binding factors C/EBP class certain adipogenic target genes, function shares with nononcogenic CHOP protein. Here we report...
Aims The treatment of bipolar disorder often includes use multiple drug therapies. Lithium is one the most commonly used treatments, but has a narrow therapeutic window. Lamotrigine, an established antiepileptic drug, emerging as potentially important new therapy in disorder. objective this two‐treatment crossover study was to determine whether lamotrigine affects lithium pharmacokinetics. Methods Twenty healthy adult men completed study. Subjects took 2 g gluconate anhydrous every 12 h...
The role of long noncoding RNAs (lncRNAs) has been verified by more and researches in recent years. However, there are few reports on cellular senescence-associated lncRNAs lung adenocarcinoma (LUAD). Therefore, to explore the prognostic effect LUAD, 279 senescence-related genes, survival information clinicopathologic parameters were derived from CellAge database Cancer Genome Atlas (TCGA) database. Then, we constructed a novel predictive signature (CS-ALPS) consisting 6 lncRNAS (AC026355.1,...
Fetal growth restriction (FGR) is one of the most common fetal complications during pregnancy in obstetrics department, with poor therapeutic efficacy. The local inflammatory response placenta has gradually become known as main mechanism for occurrence and development FGR. aim this study was to improve knowledge placental mechanisms regulating gene expression.The differentially expressed genes (DEGs) FGR patients were analyzed through bioinformatics analysis. expression level detected by...
Abstract β ‐TrCP is an E3 ubiquitin ligase that plays important roles in multiple human cancers including esophageal squamous cell carcinoma (ESCC). Analysis of ESCC patient samples reveal only protein level but not transcript associated with prognosis, suggesting regulators stability play essential role progression and may be novel targets to develop therapies. Although known mediated by the ubiquitin‐proteasome system, it unclear which enzymes a major determine context ESCC. In this study,...
This research asks "What is it like for a K-12 school-age child to learn in massive open online course (MOOC)?" Evidence suggested that significant number of children are participating MOOCs either independently or alongside their parents, both inside and outside the school system. Researchers have expressed concerns regarding how these self-directed, learning environments may alter children's study patterns habits. However, little scholarly attention has been devoted this unique phenomenon....
Background. The roles of the sympathetic and parasympathetic systems in mediating effect electroacupuncture (EA) at ST37 on jejunal motility have yet to be demonstrated. Aim . We used rats mice investigate mechanism action EA motility. Methods. Jejunal was recorded by a balloon placed jejunum connected biological signal collection system through transducer. effects (3 mA) were evaluated Sprague-Dawley without drugs with administration clenbuterol, propranolol, acetylcholine, atropine....