A5003348866- Viral Infectious Diseases and Gene Expression in Insects
- Immune Cell Function and Interaction
- Zebrafish Biomedical Research Applications
- Developmental Biology and Gene Regulation
- Neurogenesis and neuroplasticity mechanisms
- Coccidia and coccidiosis research
- Monoclonal and Polyclonal Antibodies Research
- Toxin Mechanisms and Immunotoxins
- Helminth infection and control
- Diatoms and Algae Research
- Algal biology and biofuel production
- Immune Response and Inflammation
- Cytokine Signaling Pathways and Interactions
- Platelet Disorders and Treatments
- Glycosylation and Glycoproteins Research
- Hematopoietic Stem Cell Transplantation
- Chronic Lymphocytic Leukemia Research
- Immunotherapy and Immune Responses
- GABA and Rice Research
- Fungal and yeast genetics research
- Amino Acid Enzymes and Metabolism
- T-cell and B-cell Immunology
- Agricultural safety and regulations
- Immunodeficiency and Autoimmune Disorders
- Animal Genetics and Reproduction
University College London
2008-2022
Vanderbilt University
1994-2021
Attogen Biomedical Research
2013
Pfizer (United States)
1999-2000
New York University
1999
University of California, San Diego
1997
Reproductive Genetics Institute
1997
Rush University Medical Center
1997
Centre National de la Recherche Scientifique
1994
University of Florida
1986
A 4-kilobase complementary DNA (cDNA) encoding human macrophage-specific colony-stimulating factor (CSF-1) was isolated. When introduced into mammalian cells, this cDNA directs the expression of CSF-1 that is structurally and functionally indistinguishable from natural urinary CSF-1. Direct structural analysis both recombinant purified protein revealed these species contain a sequence at least 40 amino acids their carboxyl termini which are not found in coding region 1.6-kilobase previously...
Interleukin-3 (IL-3) is a member of family growth factors, each which supports the proliferation and development hematopoietic precursors in culture. Although biologic effects different factors have been well documented culture systems, it has only recently become possible to study activities these molecules vivo. In comparison with later acting granulocyte-macrophage colony-stimulating factor (GM-CSF) granulocyte factor, IL-3 elicited delayed relatively modest leukocytosis when continuously...
Abstract Two components of a receptor complex for IL-13, the IL-4R and low affinity IL-13-binding chain, IL-13Rα1, have been cloned in mice humans. An additional high binding chain IL-13Rα2, has described We isolated cDNA from thymus that encodes murine orthologue human IL-13Rα2. The predicted protein sequence IL-13Rα2 (mIL-13Rα2) 59% overall identity to is closely related subunit, IL-13Rα1. genes both mIL-13-binding chains map X chromosome. A specific interaction between mIL-13Rα2.Fc IL-13...
Interleukin 6 (IL-6) is a major growth factor for tumor plasma cells involved in human multiple myeloma (MM). In particular, cell lines (HMCL), whose completely dependent on addition of exogenous IL-6, can be obtained reproducibly from every patient with terminal disease. Four cytokines, ciliary neurotropic (CNTF), IL-11, leukemia inhibitory (LIF), and oncostatin M (OM), use the same transducer chain (signal gp130) as IL-6 share numerous biological activities this IL. We found that these...
The habenulae are bilateral nuclei located in the dorsal diencephalon that conserved across vertebrates. Here we describe main afferents to larval and adult zebrafish. We observe from subpallium, nucleus rostrolateralis, posterior tuberculum, hypothalamic lobe, median raphe, olfactory bulb right habenula parapineal left habenula. In addition, find a ventrolateral telencephalic neurochemical hodological data identify as ventral entopeduncular (vENT), confirming extending observations of Amo...
Abstract The growth‐promoting activities of optimally stimulating concentrations leukemia inhibitory factor (LIF) and interleukin‐11 (IL‐11), a stromal cell‐derived cytokine, on megakaryocytes in liquid marrow cultures were compared to interleukin‐6 (IL‐6), known megakaryocytic maturation factor. Maximally LIF (25 ng/ml), IL‐11 (10 or IL‐6 alone ng/ml) promoted an 81, 157, 153% increase, respectively, acetylcholinesterase (AchE) activity murine serum‐free with controls (n = 5). In...
Inward-rectifying K+ (K+in) channels in the guard cell plasma membrane have been suggested to function as a major pathway for influx into cells during stomatal opening. When K+in were blocked with external Cs+ wild-type Arabidopsis cells, light-induced opening was reduced. Transgenic plants generated that expressed mutant of channel, KAT1, which shows enhanced resistance block. Stomata these transgenic lines opened presence Cs+. Patch-clamp experiments showed inward K+(in) currents less by...
Abstract We have studied the interaction of 35 S‐labeled recombinant IL‐3 with acute myelogenous leukemia cell line, KG‐1. S‐IL‐3 bound to these cells in a time dependent, saturable, and specific manner at 4°C. Scatchard transformation binding isotherms demonstrated existence small number (200) sites, an apparent dissociation constant 70‐105 pM. After temperature shift from 4°C 37°C, surface‐bound was rapidly internalized processed into trichloroacetic acid soluble form that released medium....
It is currently unclear how intrinsic and extrinsic mechanisms cooperate to control the progression from self-renewing neurogenic divisions in retinal precursor cells. Here, we use zebrafish flotte lotte (flo) mutant, which carries a mutation elys (ahctf1) gene, study relationship between cell cycle neuronal differentiation by investigating proliferating progenitor cells transition towards stem niche termed ciliary marginal zone (CMZ). In embryos without Elys, CMZ retain capacity proliferate...
The nucleotide sequence of 5'-noncoding and N-terminal coding regions two coordinately regulated, repressible acid phosphatase genes from Saccharomyces cerevisiae were determined. These unlinked encode different, but structurally related polypeptides molecular weights 60,000 56,000. DNA sequences their 5'-flanking show stretches extensive homology upstream of, surrounding, a "TATA" in region which heterogeneous 5' ends the p60 mRNA mapped. predicted amino encoded by both confirmed...
The prevalence of serum IgE antibodies to Dermatophagoides pteronyssinus (house-dust mite), Aspergillus fumigatus, and bovine beta-lactoglobulin was significantly greater in cases sudden infancy death (S.I.D.) than a control group infants the same age range. This difference most pronounced with D. antibodies, which suggests that hypersensitivity house-dust mite may be factor aetiology S.I.D. Western Australia. Both had similar concentrations immunoglobulins G, M, E but IgA levels were higher group.
The TLS-CHOP oncoprotein, found in the majority of human myxoid liposarcomas, consists a fusion between transcription factor CHOP/GADD153 and N terminus an RNA-binding protein TLS/FUS. Clinical correlation vitro transformation assays indicate that TLS plays important role oncogenesis by TLS-CHOP. Until now, however, only activity attributed to oncoprotein is inhibiting binding factors C/EBP class certain adipogenic target genes, function shares with nononcogenic CHOP protein. Here we report...