A5100440307- Ubiquitin and proteasome pathways
- Cancer-related Molecular Pathways
- Peptidase Inhibition and Analysis
- Cancer, Hypoxia, and Metabolism
- interferon and immune responses
- Endoplasmic Reticulum Stress and Disease
- Mitochondrial Function and Pathology
- Galectins and Cancer Biology
- Epigenetics and DNA Methylation
- Tardigrade Biology and Ecology
- RNA modifications and cancer
- Infectious Diseases and Mycology
- Biocrusts and Microbial Ecology
- Spaceflight effects on biology
- PI3K/AKT/mTOR signaling in cancer
- Lung Cancer Treatments and Mutations
Beijing Proteome Research Center
2020-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2022-2023
First Affiliated Hospital of Nanchang University
2023
Nanchang University
2023
State Key Laboratory of Proteomics
2020-2021
Sichuan University
2015
Snail is a prominent epithelial-mesenchymal transition (EMT) transcription factor and promotes metastasis. However, protein unstable quickly degraded through ubiquitination-mediated proteasome pathway. Deubiquitinases prevent degradation by regulating the hydrolysis process. Our studies demonstrate that deubiquitinating enzyme (DUB) family member, USP37, can deubiquitinate of Snail. USP37 co-localized with in nucleus. Biologically, upregulated expression lung cancer cell migration, while...
Tardigrades are captivating organisms known for their resilience in extreme environments, including ultra-high-dose radiation, but the underlying mechanisms of this remain largely unknown. Using genome, transcriptome, and proteome analysis
Abstract β ‐TrCP is an E3 ubiquitin ligase that plays important roles in multiple human cancers including esophageal squamous cell carcinoma (ESCC). Analysis of ESCC patient samples reveal only protein level but not transcript associated with prognosis, suggesting regulators stability play essential role progression and may be novel targets to develop therapies. Although known mediated by the ubiquitin‐proteasome system, it unclear which enzymes a major determine context ESCC. In this study,...
Abstract Linear ubiquitination catalyzed by HOIL-1-interacting protein (HOIP), the key component of linear assembly complex, plays fundamental roles in tissue homeostasis executing domain-specific regulatory functions. However, a proteome-wide analysis interactome HOIP across tissues is lacking. Here, we present comprehensive mass spectrometry-based profiling four domains nine mouse tissues. The interaction dataset provides high-quality resource with an average approximately 90 interactors...
Linear ubiquitination is a reversible posttranslational modification, which plays key roles in multiple biological processes. ubiquitin chain assembly complex (LUBAC) catalyzes linear ubiquitination, while the deubiquitinase OTULIN (OTU with linkage specificity, FAM105B) exclusively cleaves chains. However, our understanding of restricted to few substrates and pathways. Here we used human proteome microarray detect interacting proteins LUBAC by systematically screening up 20,000 proteins. We...