A5043861769- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Luminescence and Fluorescent Materials
- Organic Light-Emitting Diodes Research
- Supramolecular Chemistry and Complexes
- Nanoplatforms for cancer theranostics
- Psychedelics and Drug Studies
- Metal-Organic Frameworks: Synthesis and Applications
- Crystallography and molecular interactions
- Organic Electronics and Photovoltaics
- Magnetism in coordination complexes
- Neurotransmitter Receptor Influence on Behavior
- Physics of Superconductivity and Magnetism
- Advanced Photocatalysis Techniques
- Photodynamic Therapy Research Studies
- Molecular Sensors and Ion Detection
- Nanocluster Synthesis and Applications
- Polyoxometalates: Synthesis and Applications
- Cancer, Hypoxia, and Metabolism
- Advanced Nanomaterials in Catalysis
- TiO2 Photocatalysis and Solar Cells
- Metal complexes synthesis and properties
- Memory and Neural Mechanisms
- Advanced Condensed Matter Physics
- Supramolecular Self-Assembly in Materials
Daping Hospital
2025
Army Medical University
2025
South China University of Technology
2024
Chinese Academy of Sciences
1991-2020
Institute of Physics
2000-2020
Institute of Pharmacology
2017
Centre National de la Recherche Scientifique
2007-2015
Institut des Sciences Chimiques de Rennes
2007-2015
Université de Rennes
2007-2015
Générale-Beaulieu Clinic
2015
Background: Psilocybin offers new hope for treating mood disorders due to its rapid and sustained antidepressant effects, as standard medications require weeks or months exert their effects. However, the mechanisms underlying this action of psilocybin have not been identified. Aims: To investigate whether has antidepressant-like effects in mice potential are related promoted neuroplasticity. Methods: We first examined normal by forced swimming test chronic corticosterone (CORT)-exposed...
Abstract Background: Posttraumatic stress disorder (PTSD) and depression are highly comorbid. Psilocybin exerts substantial therapeutic effects on by promoting neuroplasticity. Fear extinction is a key process in the mechanism of first-line exposure-based therapies for PTSD. We hypothesized that psilocybin would facilitate fear hippocampal Methods: First, we assessed percentage freezing time an auditory cued conditioning (FC) paradigm mice. was administered 30 min before training. testing...
Three new starburst DCM (4-(dicyanomethylene)-2-methyl-6-[4-(dimethylaminostyryl)-4H-pyran]) derivatives, 4,4′,4′′-tris[2-(4-dicyanomethylene-6-t-butyl-4H-pyran-2-yl)-ethylene]triphenylamine (TDCM), 4,4′,′′-tris[2-(4-(1′,3′-indandione)-6-t-butyl-4H-pyran-2-yl)-ethylene]triphenylamine (TIN), and 4-methoxy-4′,4′′-bis[2-(4-(1′,3′-indandione)-6-t-butyl-4H-pyran-2-yl)-ethylene]triphenylamine (MBIN), have been designed synthesized for application as red-light emitters in organic light-emitting...
Psychedelics alter consciousness and may have potential for drug development. As psychedelics are likely therapeutically active, it is important to study their effects mechanisms using preclinical models. Here, we examined the of phenylalkylamine indoleamine on locomotor activity exploratory behaviour mouse Behavioural Pattern Monitor (BPM). DOM, mescaline, psilocin reduced at high doses influenced rearings, an behaviour, in a characteristic inverted U-shaped dose-response function....
Tardigrades are captivating organisms known for their resilience in extreme environments, including ultra-high-dose radiation, but the underlying mechanisms of this remain largely unknown. Using genome, transcriptome, and proteome analysis
Abstract 2‐(2‐ tert ‐Butyl‐6‐(( E )‐2‐(2,6,6‐trimethyl‐2,4,5,6‐tetrahydro‐1 H ‐pyrrolo[3,2,1‐ ij ]quinolin‐8‐yl)vinyl)‐4 ‐pyran‐4‐ylidene)malononitrile (DCQTB) is designed and synthesized in high yield for application as the red‐light‐emitting dopant organic light‐emitting diodes (OLEDs). Compared with 4‐(dicyanomethylene)‐2‐ ‐butyl‐6‐(1,1,7,7,‐tetramethyljulolidyl‐9‐enyl)‐4 ‐pyran (DCJTB), one of most efficient red‐emitting dopants, DCQTB exhibits red‐shifted fluorescence but blue‐shifted...
Abstract The reaction of U‐shaped, bimetallic, Cu I complexes, assembled from a heteroditopic pincer, with cyano‐capped π‐conjugated linkers gives straightforward access to π‐stacked metallocyclophanes in good yields. In these assemblies, the π‐walls have an almost face‐to‐face arrangement. versatility this rational supramolecular synthesis is demonstrated use that nanoscale lengths (up 27.7 Å), different chemical compositions (oligo( para ‐phenylenevinylene)s OPVs, oligo(phenylene)s,...
Ru(ii) polypyridyl complexes which can undergo photo-induced ligand dissociation and DNA covalent binding are considered as potential photoactivated chemotherapeutic (PACT) agents. Herein four pyridine-2-sulfonate (py-SO3-) based [Ru(N-N)2(py-SO3)]+ (1-4) were synthesized studied. All the fast py-SO3- upon visible light irradiation. However, only complex 4 exhibited high anticancer activities towards a series of cancer cells, with half maximal inhibitory concentration (IC50) values in...
Stringing letters together: Coordination polymers (CPs) featuring unprecedented F-shaped dinuclear CuI connectors and π-stacked metallocyclophane moieties are obtained in a one-pot synthesis from their molecular components (see picture; dppm=bis(diphenylphosphino)methane; Cu pink, C gray, H white, N blue, P red). The characterization of potential intermediate suggests that these CPs formed through multilevel self-assembly process. Supporting information for this article is available on the...
BSA@Fe/Ru nanoparticles with photocatalytic supplement of H 2 O and hydroxyl radical production at a neutral pH are developed, which display efficient selective chemodynamic therapy (CDT) activity both in vitro vivo .
Abstract Background Fasting is an important pre‐analytical factor that may affect clinical pathology parameters in toxicological and pharmacological studies. Little information available on how fasting affects cynomolgus monkeys ( Macaca fascicularis ).The aim of this study was to evaluate the influence healthy adult monkeys. Methods Five female six male were fasted for 0, 8, 16, 24 hours. Changes body weight (BW), core hematologic, serum chemical evaluated. Results The BW significantly...
The first example of the synthesis mono-N,O-B-chelated dipyrromethene (BODIPY) derivatives through an unexpected intramolecular nucleophilic displacement fluorine by alkenols in presence boron trifluoride as Lewis acid is reported. chlorine indacene core allowed for further structural modifications substitutions or palladium-catalysed coupling reactions to afford new fluorophores with tuneable photophysical properties. Their expanded conjugation structure resulted distinct red-shifted...
Using 2H-indene-1,3-dione as an electron-withdrawing group and aromatic amines of different structures electron-donating groups, four new DCM-type dyes, IN-1, IN-2, IN-3, IN-4, were designed synthesized for application in organic light-emitting diodes (OLEDs) red materials. IN-2 exhibits a shift fluorescence but blue absorption with respect to IN-1. Similarly, IN-4 IN-3. These unique photophysical properties utilized optimize the electroluminescence color purity efficiency these emitters...
Novel antibacterial agents capable of efficiently sterilizing intracellular Staphylococcus aureus and methicillin-resistant S. (MRSA) but with low cytotoxicity resistance development are quite appealing. In this work, three Ru(II) complexes photolabile ligands were explored to realize such a goal. Complex 3 (5 μM) can inhibit more than 90% growth aureus/MRSA that has invaded in J774A.1 cells upon visible light irradiation, being much efficient vancomycin. similar conditions, negligible dark-...
Coordination-driven supramolecular synthesis of new π-stacked metallacycles based on flexible π-conjugated linkers and having a ‘pseudo double-paracyclophane’ structure is presented.
In an attempt to improve the antitumor activity and reduce side effects of irinotecan (2), novel prodrugs SN-38 (3) were prepared by conjugating amino acids or dipeptides 10-hydroxyl group via a carbamate linkage. The synthesized compounds completely generated in pH 7.4 buffer human plasma, while remaining stable under acidic conditions. All prodrug demonstrated much greater vitro activities against HeLa cells SGC-7901 than irinotecan. most active compounds, 5h, 7c, 7d, 7f, exhibited IC50...
Near infrared (NIR) fluorescent sensor for biologically important analyte is very promising because NIR fluorescence imaging has minimal autofluorescence and high tissue penetration in living system. Nevertheless, its low quantum yield leads to sensitivity of detection. In this study, a functionalized gold nanorods (NIR-AuNRs-3) plasmon enhanced fluorescence-based adenosine triphosphate (ATP) was developed with highly improved sensitivity. The ATP significantly enhanced, from almost zero...
BSA modified UCNPs covalently loaded with a Ru(<sc>ii</sc>) PACT agent were constructed, which showed tumor-specific and NIR light-triggered efficient anticancer activity both <italic>in vitro</italic> vivo.</italic>
By modifying the ligand and replacing counteranions, luminescence color of [Cu(N^N)(bdppmapy)] + complexes changes from pure green (533 nm) to amber (604 nm).