We report a ratiometric fluorescent sensor based on monochlorinated BODIPY for highly selective detection of glutathione (GSH) over cysteine (Cys)/homocysteine (Hcy). The chlorine the can be rapidly replaced by thiolates biothiols through thiol–halogen nucleophilic substitution. amino groups Cys/Hcy but not GSH further replace thiolate to form amino-substituted BODIPY. significantly different photophysical properties sulfur- and enable discrimination Cys Hcy. was applied in living cells.

Abstract Developing Type‐I photosensitizers is considered as an efficient approach to overcome the deficiency of traditional photodynamic therapy (PDT) for hypoxic tumors. However, it remains a challenge design generating reactive oxygen species by process. Herein, we report series α,β‐linked BODIPY dimers and trimer that exclusively generate superoxide radical (O 2 −. ) process upon light irradiation. The triplet formation originates from effective excited‐state relaxation initially...

The highly oxygen-dependent nature of photodynamic therapy (PDT) limits its therapeutic efficacy against hypoxic solid tumors in clinics, which is an urgent problem to be solved. Herein, we develop oxygen-independent supramolecular agent that produces hydroxyl radical (•OH) by oxidizing water the presence intracellularly abundant pyruvic acid under oxygen-free conditions. A fluorene-substituted BODIPY was designed as electron donor and coassembled with perylene diimide acceptor form...

A supramolecular strategy is reported for converting the conventional photodynamic agents from a singlet oxygen generator to superoxide radical by host–guest interaction enhanced electron transfer.

Abstract Given that Type-I photosensitizers (PSs) have hypoxia tolerance, developing general approaches to prepare PSs is of great importance, but remains a challenge. Here, we report supramolecular strategy for the preparation photodynamic agents, which simultaneously generate strong oxidizing cationic radicals and superoxide radicals, by introducing electron acceptors existing Type-II PSs. As proof-of-concept, three were designed co-assembled with classical PS produce quadruple...

It is a challenge to design photosensitizers balance between the tumor-targeting enrichment for precise treatment and efficient clearance within reasonable timescale reducing side effects. Herein, an ultra-small nano-photosensitizer 1a with excellent tumor-specific accumulation renal reported. formed from self-assembly of compound 1 bearing three triethylene glycol (TEG) arms two pyridinium groups in water. The positively charged surface neutral TEG coating enables efficiently target tumor,...

We herein present an approach of photo-induced disproportionation for preparation Type-I photodynamic agents. As a proof concept, BODIPY-based photosensitizers were rationally designed and prepared. The intermolecular electron transfer between homotypic chromophores leads to the reaction, resulting in formation charged intermediates, cationic anionic radicals. radicals efficiently oxidize cellularimportant coenzyme, tetrahydrobiopterin (BH

We report a turn-on fluorescent sensor based on nitrothiophenolate boron dipyrromethene (BODIPY) derivatives for the discrimination of cystein (Cys) from homocystein (Hcy) and glutathione (GSH). The was applied detection Cys in living cells.

Abstract We report the first highly efficient artificial light‐harvesting systems based on nanocrystals of difluoroboron chromophores to mimic chlorosomes, one most found in green photosynthetic bacteria. Uniform with controlled donor/acceptor ratios were prepared by simple coassembly donors and acceptors water. The system funneled excitation energy collected a thousand donor single acceptor. well‐defined spatial organization individual enabled an transfer efficiency 95 %, even at ratio as...

Cysteine (Cys), homocysteine (Hcy), and glutathione (GSH) are interconnected play essential roles for regulating the redox balance of biological processes. However, finding a simple effective method simultaneous determination these three biothiols in systems is always challenge. In this work, we report quantitative mixture using monochlorinated boron dipyrromethene (BODIPY)-based fluorometric sensor. At specified period time, after reacting with excess sensor, Hcy GSH form predominantly...

A carbazole‐containing difluoroboron β‐diketonate complex ( BCZ ), which shows strong fluorescence in both the solid state and organic solutions, is reported. The crystalline materials of obtained from different solvents display emission colors. Single‐crystal analysis reveals that enhanced overlap between adjacent molecules induces increased excited‐state delocalization responsible for variation colors yellow to red. are effectively tuned by external stimuli such as grinding, heating,...

Aggregation-induced emission luminogens (AIEgens) have attracted increasing attention in recent years on account of their attribute overcoming the aggregation-caused quenching (ACQ) phenomenon conventional organic fluorophores. Despite remarkable advantages and great developments, most AIEgens exhibit broad spectra with full width at half-maxima (FWHM) over 100 nm, which is to disadvantage practical applications. Herein, supramolecular polymeric AIE materials brighter fluorescence narrower...

Biothiols and SO2 derivatives, as essential reactive sulfur species (RSS), play vital roles in various physiological processes have a close network of generation metabolic pathways among them. To clarify their complex correlations, fluorescent probes to simultaneously detect GSH, Cys, derivatives are highly desirable. Herein, we develop the first probe (BO-HEM) discriminate derivatives. The is designed by integration hemicyanine BODIPY fluorophores through an ether bond. bond rapidly...

A facile approach for the preparation of supramolecular polymer‐based fluorescent nanoparticles (FNPs) is reported. FNPs with homogeneous shape and size distribution are fabricated from low‐molecular‐weight molecules, thus, different compositional constituents can be efficiently incorporated via copolymerization. The emission color covers a wide region blue to near infrared easily tuned using efficient excitation energy transfer. photoswitchable high on–off fluorescence contrast also simply...

Biological thiols, including cysteine (Cys), homocysteine (Hcy) and glutathione (GSH), play important roles in maintaining the appropriate redox status of biological systems. The discrimination between them is great importance because their different roles. Herein, we present a new near-infrared (NIR) fluorescent sensor Cy-NO2 for selective detection Cys over Hcy/GSH. nitrothiophenol group introduced to quench fluorescence through photo-induced electron transfer (PET). undergoes displacement...

Artificial light-harvesting nanoparticles were prepared from supramolecular polymers comprised of pillar[5]arene with anthracene-derived donors and acceptors through host-guest interactions. The resulting water-dispersible displayed efficient energy transfer excellent light harvesting ability in part because the steric bulk suppressed self-quenching chromophores.

Nitric oxide (NO) and glutathione (GSH) have interplaying roles in oxidant-antioxidant balance. In this work, we developed the first example of a single fluorescent probe that displayed turn-on fluorescence response toward NO GSH from dual emission channels. The was synthesized by introducing 4-amino-3-(methylamino)-phenol to BODIPY scaffold. Specifically, NO-mediated transformation diamine into triazole triggered green channel, GSH-induced SNAr substitution reaction led red-shifted red...

The “dual lock-and-key” supramolecular photosensitizers enable specific and enhanced photodynamic therapy (PDT).

Abstract An organic crystal of 4,4′‐bis(N‐carbazolyl)‐1,1′‐biphenyl (pCBP) exhibits time‐dependent afterglow color from blue to orange over 1 s. Both experimental and computational data confirm that the evolution results well‐separated, long‐persistent thermally activated delayed fluorescence (TADF) room‐temperature phosphorescence (RTP) with different but comparable decay rates. TADF is enabled by a small S –T energy gap 0.7 kcal mol −1 . The good separation RTP due 11.8 difference in 0...

Structural modifications are a successful and commonly used approach to tune the emission properties of diverse fluorophores, but extending this heavy-atom-free persistent luminophores ...