A5100694730- HIV-related health complications and treatments
- Head and Neck Cancer Studies
- Advanced biosensing and bioanalysis techniques
- Nanoparticle-Based Drug Delivery
- Diabetes Management and Research
- Nanoplatforms for cancer theranostics
- Glaucoma and retinal disorders
- Heart Rate Variability and Autonomic Control
- Non-Invasive Vital Sign Monitoring
- Helicobacter pylori-related gastroenterology studies
- Liver Disease Diagnosis and Treatment
- RNA Interference and Gene Delivery
- Lung Cancer Research Studies
- Extracellular vesicles in disease
- Acute Myeloid Leukemia Research
- HIV Research and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Pancreatic function and diabetes
- Cervical Cancer and HPV Research
- Atherosclerosis and Cardiovascular Diseases
- Lipid Membrane Structure and Behavior
- Molecular Sensors and Ion Detection
- Hepatitis B Virus Studies
- Advanced Surface Polishing Techniques
- Diabetes, Cardiovascular Risks, and Lipoproteins
Lishui University
2022-2025
Wenzhou Medical University
2008-2025
Shanghai Children's Medical Center
2017-2025
Shanghai Jiao Tong University
2018-2025
Shanghai Sixth People's Hospital
2019-2025
China Institute of Sport Science
2024-2025
Zhejiang Lab
2025
Jinzhou Kangning Hospital
2025
Northeastern University
2025
Hangzhou Normal University
2025
Introduction: This trial assessed safety and effectiveness of an advanced hybrid closed-loop (AHCL) system with automated basal (Auto Basal) bolus correction Correction) in adolescents adults type 1 diabetes (T1D). Materials Methods: multicenter single-arm study involved intent-to-treat population 157 individuals (39 aged 14-21 years 118 ≥22-75 years) T1D. Study participants used the MiniMed™ AHCL during a baseline run-in period which sensor-augmented pump +/- predictive low glucose...
Synthetic ester oil (SEO) is promising for bolstering sustainable development and enhancing operational reliability of transformers at low-temperature. The intention this study to acquire understanding differential low-temperature AC breakdown characteristics exhibited by SEO mineral (MO), while delving into the microscopic influencing factors. results unveil that voltage between -20°C 20°C illustrates a "V"-shaped trend, with consistently higher than MO. presents its maximum minimum 0°C,...
Ren, Yan‐Dan; Ye, Zhen‐Shi; Yang, Liu‐Zhu; Jin, Li‐Xin; Wei, Wen‐Jun; Deng, Yong‐Yue; Chen, Xiao‐Xiao; Xiao, Chuan‐Xing; Yu, Xiao‐Fang; Xu, Hong‐Zhi; Li‐Zhu; Tang, Yun‐Na; Zhou, Fei; Wang, Xue‐Lian; Mei‐Ya; Li‐Gang; Hong, Mei‐Zhu; Jian‐Lin; Pan, Jin‐Shui Author Information
The synthesis, multilevel structural features, adsorption performance and environmental applications of graphene nanosheets 2D/3D graphene-based macrostructure material were summarized.
Patients who survive influenza A (H7N9) virus infection are at risk of physical and psychological complications lung injury multi-organ dysfunction. However, there were no prospectively individualized assessments physiological, functional quality-of-life measures after hospital discharge. The current study aims to assess the main determinants disability these patients during follow-up. Fifty-six survivors investigated 2-year discharge from hospital. Results show interstitial change fibrosis...
Mushroom showed pellet, clump and/or filamentous mycelial morphologies during submerged fermentation. Addition of microparticles including Talc (magnesium silicate), aluminum oxide and titanium could control to improve mycelia growth secondary metabolites production. Here, effect microparticle (45 μm) addition on the morphology, fermentation performance, monosaccharide compositions polysaccharides enzymes activities associated with polysaccharide synthesis in G. frondosa was well...
Real-world data from the first 3141 patients who completed 3 months of SmartGuard™ Auto Mode-enabled MiniMed™ 670G system use during MiniMed System Commercial Launch are reported. CareLink™ uploaded by real-world in March 17, 2017 to December 31, were deidentified and analyzed. Comparisons overall night (10:00 PM-07:00 AM) time spent below, within, above target glucose range (TIR) (70-180 mg/dL) between baseline Manual Mode closed-loop periods made. These evaluated alongside 124 (aged 14-75...
Nitric oxide (NO) and glutathione (GSH) have interplaying roles in oxidant-antioxidant balance. In this work, we developed the first example of a single fluorescent probe that displayed turn-on fluorescence response toward NO GSH from dual emission channels. The was synthesized by introducing 4-amino-3-(methylamino)-phenol to BODIPY scaffold. Specifically, NO-mediated transformation diamine into triazole triggered green channel, GSH-induced SNAr substitution reaction led red-shifted red...
The aim of this study was to evaluate the outcomes transitioning MiniMed 780G advanced hybrid closed-loop (AHCL) system in adult individuals with type 1 diabetes mellitus (T1DM) naive continuous subcutaneous insulin infusion (CSII) and glucose monitoring (CGM) technologies.This a two-center, randomized, controlled, parallel-group trial evaluation T1DM aged 26-60 years managed multiple daily injections (MDI) self-monitoring blood (BGM) HbA1c <10%.A total 41 participants were recruited...
The cyclic GMP-AMP synthase (cGAS)-stimulator of interferon (STING) pathway is a key mediator innate immunity involved in cancer development and treatment. roles mitochondrial DNA (mtDNA) immunotherapy have gradually emerged. Herein, we report highly emissive rhodium(iii) complex (Rh-Mito) as the mtDNA intercalator. Rh-Mito can specifically bind to cause cytoplasmic release fragments activate cGAS-STING pathway. Moreover, activates retrograde signaling by disturbing metabolites epigenetic...
Abstract Dielectric capacitors, characterized by ultra‐high power densities, are considered as fundamental energy storage components in electronic and electrical systems. However, synergistically improving densities efficiencies remains a daunting challenge. Understanding the role of polarity heterogeneity at nanoscale determining polarization response is crucial to domain engineering high‐performance dielectrics. Here, bidirectional design with phase‐field simulation machine learning...
Abstract Dielectric capacitors offer great potential for advanced electronics due to their high power densities, but energy density still needs be further improved. High-entropy strategy has emerged as an effective method improving storage performance, however, discovering new high-entropy systems within a high-dimensional composition space is daunting challenge traditional trial-and-error experiments. Here, based on phase-field simulations and limited experimental data, we propose...
Abstract Organic photoluminescent materials with room‐temperature phosphorescence (RTP) are of great interest, yet achieving RTP in hydrogels faces challenges due to water‐quenching effects. In this study, a straightforward method is presented achieve hydrogel using self‐healing and salt‐hardening hydrogel. The synthesized by polymerizing acrylic acid (AA) diethylenetriamine (DETA) as the dynamic crosslinker. poly(acrylic acid)/DETA could an afterglow lasting 1.6 s after soaking NaBr...
A new C-type lectin-like gene encodes 293 amino acids and maps to chromosome 19p13.3 adjacent the previously described lectin genes, CD23, dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin (DC-SIGN), DC-SIGN-related protein (DC-SIGNR). The four genes form a tight cluster in an insert size of 105 kb have analogous genomic structures. molecule, designated liver lymph node sinusoidal endothelial cell (LSECtin), is type II integral membrane ∼40 kDa with single domain...
Clarifying the signaling pathway associated with nitric oxide (NO) and glutathione (GSH) in cardiovascular disease therapy is important for understanding its physiological pathological processes but challenging due to lack of efficient analytical techniques. Herein, we report a BODIPY-based fluorescent probe recognition NO GSH sequence high sensitivity selectivity. The exhibits turn-on fluorescence triggered by NO, followed red-shifted emission presence GSH. sequentially activated mechanism...
Summary Millions of people die from liver diseases annually, and failure is one the three major outcomes disease. The gut microbiota plays a crucial role in diseases. This study aimed to explore effects Lactobacillus casei strain Shirota (LcS), probiotics used widely around world, on acute injury (ALI), as well underlying mechanism. Sprague Dawley rats were intragastrically administered LcS suspensions or placebo once daily for 7 days before induction ALI by intraperitoneal injection...
Hypoxia at the tumor site limits therapeutic effects of photodynamic therapy (PDT) in oral squamous cell carcinoma (OSCC), which is an oxygen-consumption process. Inhibiting cellular oxygen consumption and reducing ATP production are expected to enhance PDT. In this study, we designed constructed dandelion-like size-shrinkable nanoparticles for tumor-targeted delivery hypoxia regulator resveratrol (RES) agent chlorine e6 (CE6). Both drugs were co-encapsulated small-sized micelles modified...
Advanced hepatocellular carcinoma (HCC) is a severe malignancy that poses serious threat to human health. Owing challenges in early diagnosis, most patients lose the opportunity for radical treatment when diagnosed. Nonetheless, recent advancements cancer immunotherapy provide new directions of HCC. For instance, monoclonal antibodies against immune checkpoint inhibitors (ICIs) such as programmed cell death protein 1/death ligand-1 and cytotoxic t-lymphocyte associated antigen-4...
Abstract Glutathione (GSH)‐activated prodrugs are promising for overcoming the limitations of conventional anti‐tumor drugs. However, current GSH‐responsive disulfide groups exhibit unregulated reactivity, making it impossible to precisely control drug release rate. We herein report a series with “three‐in‐one” molecular design by integrating fluorescence unit, stimuli‐responsive unit and chemodrug into one scaffold tunable aromatic nucleophilic substitution (S N Ar) reactivity. The rate...