A5100652552- Nanoparticle-Based Drug Delivery
- RNA Interference and Gene Delivery
- Nanoplatforms for cancer theranostics
- Advanced biosensing and bioanalysis techniques
- Autophagy in Disease and Therapy
- Immunotherapy and Immune Responses
- Extracellular vesicles in disease
- Cancer Research and Treatments
- Carbon and Quantum Dots Applications
- Immune cells in cancer
- Graphene and Nanomaterials Applications
- Cancer, Hypoxia, and Metabolism
- Advanced Drug Delivery Systems
- Nanocluster Synthesis and Applications
- Protease and Inhibitor Mechanisms
- Advanced Nanomaterials in Catalysis
- Cancer, Lipids, and Metabolism
- Cancer Immunotherapy and Biomarkers
- Drug Solubulity and Delivery Systems
- Cancer Cells and Metastasis
- Inflammatory Biomarkers in Disease Prognosis
- Drug Transport and Resistance Mechanisms
- Adenosine and Purinergic Signaling
- Paraquat toxicity studies and treatments
- Chemokine receptors and signaling
Sichuan University
2016-2025
Jinhua Central Hospital
2025
Hunan University
2024-2025
Central China Normal University
2025
Stomatological Hospital of Chongqing Medical University
2024
Huazhong University of Science and Technology
2024
Central Hospital of Wuhan
2024
Xiamen University
2024
Henan Normal University
2024
Lanzhou University
2021-2024
The treatment of brain tumors remains a challenge due to the limited accumulation drugs and nanoparticles. Here, we triggered aggregation gold nanoparticles (AuNPs) using legumain enhance retention chemotherapeutics in tumors. This nanoplatform, AuNPs-A&C, is comprised Ala-Ala-Asn-Cys-Lys modified AuNPs (AuNPs-AK) 2-cyano-6-aminobenzothiazole (AuNPs-CABT). AuNPs-AK could be hydrolyzed expose 1,2-thiolamino groups on presence legumain, which occurs by click cycloaddition with contiguous cyano...
Glioma treatment using targeted chemotherapy is still far from satisfactory due to not only the limited accumulation but also multiple survival mechanisms of glioma cells, including up-regulation both autophagy and programmed cell death ligand 1 (PD-L1) expression. Herein, we proposed a combined therapeutic regimen based on functional gold nanoparticles (AuNPs)-enabled chemotherapy, inhibition, blockade PD-L1 immune checkpoint. Specifically, legumain-responsive AuNPs (D&H-A-A&C) could...
Abstract Rheumatoid arthritis (RA) is a common chronic inflammatory disorder that usually affects joints. It was found roburic acid (RBA), an ingredient from anti-RA herb Gentiana macrophylla Pall., displayed strong anti-inflammatory activity. However, its medical application limited by hydrophobicity, lack of targeting capability and unclear functional mechanism. Here, we constructed pH responsive dual-target drug delivery system hitchhiking RBA (RBA-NPs) targeted both CD44 folate...
Therapeutic outcome for the treatment of glioma was often limited due to low permeability delivery systems across blood–brain barrier (BBB) and poor penetration into tumor tissue. In order overcome these hurdles, we developed dual-targeting doxorubicin liposomes conjugated with cell-penetrating peptide (TAT) transferrin (T7) (DOX-T7-TAT-LIP) transporting drugs BBB, then targeting brain glioma, penetrating tumor. The effects were evaluated by both in vitro vivo experiments. cellular uptake...
Abstract Receptor mediated transcytosis (RMT) is a common mechanism used for nanotherapeutics to traverse the blood–brain barrier (BBB). However, of ligand modified nanoparticles via RMT likely be trapped within brain capillary endothelial cells due high binding affinity with receptors, which greatly reduces amount across BBB. Here, P‐aminophenyl‐α‐D‐mannopyranoside (MAN) decorated doxorubicin‐loaded dendrigraft poly‐l‐lysine acid‐cleavable transferrin (Tf) coating outside (DD‐MCT) proposed....
Despite the great achievements that nanomedicines have obtained so far, deep penetration of into tumors is still a major challenge in tumor treatment. The enhanced permeability and retention (EPR) effect was main theoretical foundation for using to treat solid tumor. However, antitumor efficiency modest because heterogeneous, with dense collagen matrix, abnormal vasculature, lymphatic system. Nanomedicines could only passively accumulate near leaky site vessels, they cannot reach region To...
The network of collagen I in tumors could prevent the penetration drugs loaded nanoparticles, and this would lead to impaired antitumor efficacy. In study, free losartan (an angiotensin inhibitor) was injected before treatment reduce level I, which facilitate nanoparticles. Then pH-sensitive cleavable liposomes (Cl-Lip) were subsequently exert effect. Cl-Lip constituted by PEG(5K)-Hydrazone-PE DSPE-PEG(2K)-R8. When reached tumor site enhanced permeability retention (EPR) effect, hydrolyzed...
A kind of CD was prepared using a simple one-step method and applied for non-invasive glioma imaging.
Protein corona is immediately established on the surface of nanoparticles upon their introduction into biological milieu. Several studies have shown that targeting efficiency ligand-modified attenuated or abolished owing to protein adsorption. Here, transferrin receptor-targeting ligands, including LT7 (CHAIYPRH), DT7 (hrpyiahc, all d-form amino acids), and transferrin, were used identify influence ligand size conformation formation. The results showed capacity was lost after incubation with...
Abstract Chemoimmunotherapy‐induced antitumor immune response is highly dependent on tumor autophagy. When cells are treated with chemoimmunotherapy, timely overactivated autophagy can not only lead more to death, but also participate in the endogenous antigen presentation and stimulators secretion of dying cells, thus plays a vital role. However, accurately during chemoimmunotherapy great difficulty. Here, an on‐demand cascade amplification nanoparticle (ASN) reported boost...
Tumor-associated fibroblasts (TAFs), which form a predominant stromal cellular component of the tumor microenvironment, hinder delivery nanomedicine to deep cells and lead poor prognosis tumors. However, depletion TAFs by therapeutic agents results in secretion damage response program (DRP) molecules weaken efficacy treatment. This paper reports multifunctional size-switchable nanoparticle (denoted DGL (dendrigraft poly-l-lysine) (DGL)/GEM@PP/GA) for TAF-targeted regulation penetration....
Distal metastases of tumors result from the interaction between "seeds" (circulating tumor cells, CTCs) and "soil" (premetastatic niche, PMN). Various strategies focus on CTC inhibition, but only a few inhibit PMN formation. The main predisposition formation in melanoma lies pulmonary recruitment granulocytic myeloid-derived suppressor cells (G-MDSCs, CD11b+Ly6G+ cells) induced by tumors, which increase vascular permeability secreting matrix metalloproteinase-9 (MMP-9) immunosuppression...