A5101907856- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- Extracellular vesicles in disease
- Advanced biosensing and bioanalysis techniques
- Nanoparticles: synthesis and applications
- Maritime Navigation and Safety
- Silk-based biomaterials and applications
- Gold and Silver Nanoparticles Synthesis and Applications
- Endoplasmic Reticulum Stress and Disease
- Maritime Ports and Logistics
- Advanced Photocatalysis Techniques
- MXene and MAX Phase Materials
- Polydiacetylene-based materials and applications
- Thermal Regulation in Medicine
- Hydrogen's biological and therapeutic effects
- Biosensors and Analytical Detection
- Autophagy in Disease and Therapy
- Spectroscopy and Quantum Chemical Studies
- Microfluidic and Bio-sensing Technologies
- 3D Printing in Biomedical Research
- Electrostatics and Colloid Interactions
- Material Dynamics and Properties
- Anesthesia and Neurotoxicity Research
- Drug Transport and Resistance Mechanisms
- Evaluation Methods in Various Fields
State Key Laboratory of Chemobiosensing and Chemometrics
2023
Hunan University
2022-2023
Universität Hamburg
2018-2023
Wuhan National Laboratory for Optoelectronics
2021-2022
Huazhong University of Science and Technology
2021-2022
Wuhan University of Technology
2011-2021
Philipps University of Marburg
2018
Sichuan University
2016-2018
Ministry of Transport
2013
There are still some gaps in existing knowledge the field of cancer nanotheranostics, e.g., efficiency nanoparticle-loaded cells for targeted delivery. In current study, gold nanoparticles (Au NPs) were delivered to tumors both subcutaneous tumor and lung metastasis models by intravenous injection either free Au NPs or human bone marrow mesenchymal stem (MSCs), which loaded with endocytosed NPs. By making injections same dose administrated NPs, it was possible directly compare targeting...
Abstract Receptor mediated transcytosis (RMT) is a common mechanism used for nanotherapeutics to traverse the blood–brain barrier (BBB). However, of ligand modified nanoparticles via RMT likely be trapped within brain capillary endothelial cells due high binding affinity with receptors, which greatly reduces amount across BBB. Here, P‐aminophenyl‐α‐D‐mannopyranoside (MAN) decorated doxorubicin‐loaded dendrigraft poly‐l‐lysine acid‐cleavable transferrin (Tf) coating outside (DD‐MCT) proposed....
The physicochemical properties of a set 21 different gold nanoparticles (spherical and rod-shaped (NPs) diameters with three surface coatings) were studied. Protein corona formation, in vitro uptake, effect on cell viability proliferation, vivo biodistribution these NPs determined. relation the results was analyzed by hierarchical cluster analysis, which will tell have most similar biological effects, without having to specify individual parameters. show that (Au NPs) are mainly accounted...
Abstract Inefficient tumour treatment approaches often cause fatal metastases. Here, we report a biomimetic multifunctional nanoplatform explicitly engineered with Co-based metal organic framework polydopamine heterostructure (MOF-PDA), anethole trithione (ADT), and macrophage membrane. Co-MOF degradation in the microenvironment releases Co 2+ , which results downregulation of HSP90 expression inhibition cellular heat resistance, thereby improving photothermal therapy effect PDA. H 2 S...
After an osteosarcoma excision, recurrence and bone defects are significant challenges for clinicians. In this study, the curcumin (Cur) loaded chitosan (CS) nanoparticles (CCNP) encapsulated silk fibroin (SF)/hyaluronic acid esterified by methacrylate (HAMA) (CCNPs-SF/HAMA) hydrogel therapy regeneration was developed photocuring ethanol treatment. The micro or nanofibers networks were observed in CCNPs-SF/HAMA hydrogel. FTIR results demonstrated that alcohol vapor treatment caused increase...
The simultaneous therapy of tumor recurrence and bone defects resulting from surgical resection osteosarcoma is still a challenge in the clinic. Combination based on localized drug-delivery system shows great promise treatment osteosarcoma. Herein, bifunctional polydopamine (PDA)-modified curcumin (CM)-loaded silk fibroin (SF) composite (SF/CM-PDA) nanofibrous scaffolds, which combined photothermal with chemotherapy to synergistically enhance therapy, were prepared by PDA coating SF/CM...
X-ray photon correlation spectroscopy (XPCS), a synchrotron source-based technique to measure sample dynamics, is used determine hydrodynamic diameters of gold nanoparticles (Au NPs) different sizes in biological environments. In situ determined are benchmarked with values obtained by dynamic light scattering. The then applied analyze the behavior Au NPs environment. First, concentration-dependent agglomeration presence NaCl determined. Second, increase diameter upon proteins As X-rays...
This work aims to investigate the state of traffic safety in Yangtze River, taking navigation environment factors into account. Since accident data can directly represent water situation some extent, it is widely used evaluate River. The absolute index and relative are two kinds reasonable assessment data, but they hardly actual different waterways when changed. To overcome this problem, envelopment analysis (DEA) employed for evaluation aiming at environments paper. First, detailed...
The Three Gorges section of Yangtze River is great importance and complexity, where ship locks, ships cargos constitute a complex transportation logistics system. This system concentrates large amount information, some the information changes with time. obtaining manner processing method such are both important content work, without which whole would be obstructed. With cluster analysis relational grade navigation operating situation can obtained by observing stream, flow architecture under...