A5089500863- Nanoplatforms for cancer theranostics
- Composite Material Mechanics
- Virus-based gene therapy research
- RNA Interference and Gene Delivery
- Viral Infectious Diseases and Gene Expression in Insects
- Mechanical Behavior of Composites
- Nanoparticle-Based Drug Delivery
- Photoacoustic and Ultrasonic Imaging
- Shape Memory Alloy Transformations
- Extracellular vesicles in disease
- Numerical methods in engineering
- Thin-Film Transistor Technologies
- Hematopoietic Stem Cell Transplantation
- Silicon Nanostructures and Photoluminescence
- Membrane-based Ion Separation Techniques
- Advanced Surface Polishing Techniques
- Silicon and Solar Cell Technologies
- Electrospun Nanofibers in Biomedical Applications
- Cellular and Composite Structures
- Cancer, Hypoxia, and Metabolism
- Advanced Nanomaterials in Catalysis
- Analytical Chemistry and Chromatography
- Advanced DC-DC Converters
- Drug Transport and Resistance Mechanisms
- Selenium in Biological Systems
Karolinska Institutet
2016-2025
Karolinska University Hospital
2015-2025
Xi'an Jiaotong University
2023-2025
Beijing University of Chinese Medicine
2025
Betta Pharmaceuticals (China)
2025
Nantong University
2024
Beijing Friendship Hospital
2024
Capital Medical University
2024
Huaqiao University
2022-2024
Northeast Forestry University
2019-2023
Extracellular vesicles (EVs) are naturally occurring nano-sized carriers that secreted by cells and facilitate cell-to-cell communication their unique ability to transfer biologically active cargo. Despite the pronounced increase in our understanding of EVs over last decade, from disease pathophysiology therapeutic drug delivery, improved molecular tools track delivery still needed. Unfortunately, present catalogue utilised for EV labelling lacks sensitivity or not sufficiently specific....
The complexity of the cancer microenvironment makes it highly challenging for drugs to meet therapeutic requirements, significantly hampering their clinical translation. enormous potential intelligent materials that can act as themselves results in development smart drugless or drug-like architectures, offering synergistic effects. In this study, we demonstrate generation transition metal-based dichalcogenides (TMDCs)-based conformational (flower-like) nanoarchitectonics trimodal therapies...
In preclinical cancer studies, non-invasive functional imaging has become an important tool to assess tumor development and therapeutic effects. Tumor hypoxia is closely associated with aggressiveness therefore a key parameter be monitored. Recently, photoacoustic (PA) inherently co-registered high-frequency ultrasound (US) reached applicability, allowing parallel collection of anatomical information. Dual-wavelength PA can used quantify tissue oxygen saturation based on the absorbance...
X-ray-based analytics are routinely applied in many fields, including physics, chemistry, materials science, and engineering. The full potential of such techniques the life sciences medicine, however, has not yet been fully exploited. We highlight current upcoming advances this direction. describe different methodologies (including those performed at synchrotron light sources X-ray free-electron lasers) their potentials for application to investigate nano–bio interface. discussion is...
Abstract New therapeutic options for patients with ovarian cancer are urgently needed. Therefore, we evaluated the efficacy of two second-generation mesothelin (MSLN)-directed CAR T cells in orthotopic mouse models cancer. Treatment expressing an MSLN construct including CD28 domain (M28z) significantly prolonged survival, but no persistent tumor control was observed. Despite lower response rates, MSLN-4–1BB (MBBz) induced long-term remission some SKOV3–bearing mice. Tumor-infiltrating M28z...
Extracellular vesicles (EVs) have shown promise as potential therapeutics for the treatment of various diseases. However, their rapid clearance after administration could be a limitation in certain therapeutic settings. To solve this, an engineering strategy is employed to decorate albumin onto surface EVs through display binding domains (ABDs). ABDs were either included extracellular loops select EV-enriched tetraspanins (CD63, CD9 and CD81) or directly fused terminal single transmembrane...
Extracellular vesicles (EVs) are gaining ground as next-generation drug delivery modalities. Genetic fusion of the protein interest to a scaffold with high EV-sorting ability represents robust cargo loading strategy. To address paucity such proteins, we leverage simple and reliable assay that can distinguish intravesicular proteins from surface- well non-vesicular compare potential 244 candidate proteins. We identify 24 conserved abilities across five types producer cells. TSPAN2 TSPAN3...
Background Limited persistence of functional CAR T cells in the immunosuppressive solid tumor microenvironment remains a major hurdle successful translation cell therapy to treat tumors. Fine-tuning activation by mutating CD3ζ chain immunoreceptor tyrosine-based motifs (ITAMs) CD19-CAR (containing CD28 costimulatory domain) has proven extend preclinical models B malignancies. Methods In this study, two conventional second-generation MSLN-CAR constructs encoding for either co-stimulatory...
Based on the Eshelby-Mori-Tanaka theory nine effective elastic constants of an orthotropic composite reinforced with monotonically aligned elliptic cylinders, and five moduli a transversely isotropic two-dimensional randomly-oriented are derived. These given in terms cross-sectional aspect ratio volume fraction cylinders. When approaches zero, cylinders exist as thin ribbons, these very simple, explicit forms function fraction. It turns out that, case, coincide Hill’s Hashin’s upper bounds...
Cell-to-cell communication precisely controls the creation of new organs during reproductive growth. However, sensor molecules that mediate developmental signals in monocot plants are poorly understood. Here, we report DWARF AND RUNTISH SPIKELET1 (DRUS1) and DRUS2, two closely related receptor-like kinases (RLKs), redundantly control growth development rice (Oryza sativa). A drus1-1 drus2 double knockout mutant, but not either single showed extreme dwarfism barren inflorescences harbored...
Abstract Human embryonic stem (hES) cells as a renewable cell source have great prospective applications in both developmental biology research and regenerative medicine. To realize these potentials, the development of effective safe genetic manipulation methods hES is an obvious demand. We report here that baculoviral vectors were able to transduce efficiently. In transient transduction experiments, recombinant vector equipped with human elongation factor 1-α promoter woodchuck hepatitis...
Transcriptional targeting using a tissue-specific cellular promoter is proving to be powerful means for restricting transgene expression in targeted tissues. In the context of cancer suicide gene therapy, this approach may lead cytotoxic effects both and nontarget normal cells. Considering microRNA (miRNA) function post-transcriptional regulation expression, we have developed viral vector platform combining promoter-based transcriptional with miRNA glioma therapy mouse brain. The employed,...
[Yang J, Lam DH, Goh SS, Lee EX, Zhao Y, Tay FC, Chen C, Du S, Balasundaram G, Shahbazi M, Tham CK, Ng WH, Toh HC, Wang S. Tumor tropism of intravenously injected human‐induced pluripotent stem cell‐derived neural cells and their gene therapy application in a metastatic breast cancer model. https://doi.org/10.1002/stem.105110.1002/stem.1051. Stem Cells. (2012) 30: 1021–1029.] This article has been retracted at the request Institute Bioengineering Nanotechnology, Singapore. The author Mr. DH...