A5025068820- Pharmacological Effects of Natural Compounds
- Extracellular vesicles in disease
- Herbal Medicine Research Studies
- Orthopedic Infections and Treatments
- Phytochemicals and Antioxidant Activities
- Chromatography in Natural Products
- Gut microbiota and health
- Atrial Fibrillation Management and Outcomes
- Toxin Mechanisms and Immunotoxins
- Mitochondrial Function and Pathology
- Healthcare Systems and Public Health
- Natural product bioactivities and synthesis
- Dermatology and Skin Diseases
- Medicinal Plants and Bioactive Compounds
- Congenital Anomalies and Fetal Surgery
- Medical and Biological Sciences
- Plant Toxicity and Pharmacological Properties
- Neurogenetic and Muscular Disorders Research
- Metal complexes synthesis and properties
- Health Systems, Economic Evaluations, Quality of Life
- Parasitic infections in humans and animals
- Hereditary Neurological Disorders
- Drug-Induced Hepatotoxicity and Protection
- Chemical Reaction Mechanisms
- Polysaccharides and Plant Cell Walls
Chuvash State University
2015-2025
Mari State University
2020-2024
Karolinska Institutet
2020-2024
Karolinska University Hospital
2024
Ural Federal University
2019
Dmitry Rogachev National Research Center of Pediatric Hematology, Oncology and Immunology
2016
Pirogov Russian National Research Medical University
2003-2011
Extracellular vesicles (EVs) are naturally occurring nano-sized carriers that secreted by cells and facilitate cell-to-cell communication their unique ability to transfer biologically active cargo. Despite the pronounced increase in our understanding of EVs over last decade, from disease pathophysiology therapeutic drug delivery, improved molecular tools track delivery still needed. Unfortunately, present catalogue utilised for EV labelling lacks sensitivity or not sufficiently specific....
Certain Bifidobacterium strains have been shown to inhibit inflammatory responses in intestinal epithelial cells. However, the precise mechanisms of these effects, including chemical nature active compounds, remain be elucidated. Here partial characterization anti-inflammatory properties isolated from feces healthy infants is reported. It was found that conditioned media (CM) all studied are capable attenuating tumor necrosis factor-α (TNF-α) and lipopolysaccharide- (LPS) induced HT-29 cell...
Abstract Haematopoiesis dysregulation with the presence of immature myeloid and erythroid immunosuppressive cells are key characteristics immune escape phase tumour development. Here, role in vitro generated B16F10 cell‐derived extracellular vesicles (tEVs) as indirect cellular communicators, participating tumour‐induced haematopoiesis, was explored. The isolated tEVs displayed features small EVs a size range 100–200 nm, expressed common EV markers CD63, CD9, Alix, had spherical shape lipid...
Warfarin is an anticoagulant with proven efficacy in preventing thromboembolic complications patients mechanical heart valves. Genetic characteristics of the patient, such as carriage polymorphisms responsible for its pharmacokinetics (CYP2C9) and pharmacodynamics (VKORC1) are significant when selecting doses this drug.
<p dir="ltr">EVs are membrane-enclosed nanostructures released by various cell types and serve as critical mediators of intercellular communication. Their ability to transport proteins, nucleic acids, lipids has positioned EVs promising biomarkers delivery vehicles in diagnostics therapeutics. However, a comprehensive understanding their vivo biodistribution, clearance, immunomodulatory potential remains limited, hindering translational progress. The work described this thesis...
<p dir="ltr">EVs are membrane-enclosed nanostructures released by various cell types and serve as critical mediators of intercellular communication. Their ability to transport proteins, nucleic acids, lipids has positioned EVs promising biomarkers delivery vehicles in diagnostics therapeutics. However, a comprehensive understanding their vivo biodistribution, clearance, immunomodulatory potential remains limited, hindering translational progress. The work described this thesis...
Introduction Infectious spondylodiscitis is rising in incidence and often a late diagnosis identification of the causative agent. The objective was to evaluate treatment outcomes patients with infectious depending on positive/negative results intraoperative microbiological culture. Material methods Treatment 52 were retrospectively analyzed no culture growth biological samples (group I, n = 22) identified pathogen II, 30). verified using MRI imaging, test, clinical picture blood inflammation...
It is considered that glutamate excitotoxicity may be a major factor in the pathological death of neurons and mediate development neurodegenerative diseases humans. Here, we show isoliquiritigenin (ILG) at concentration 0.5-5 µM protects primary neuroglial cell culture from glutamate-induced (glutamate 100 µM). ILG (1 µM) prevented sharp increase [Ca2+]i decrease mitochondrial potential (ΔΨm). With background action (1-5 µM), there was an oxygen consumption rate (OCR) response to glutamate,...
Contact sensitivity is a classical T cell-mediated, clinically important phenomenon elicited by small molecular weight molecules (haptens) that bind to host proteins form complete antigen. In our model experiments, contact was produced in CBA mice, means of cutaneous sensitization with 2.4-dinitrofluorobenzene. We used an adoptive transfer different populations splenocytes, order detect immunosuppressive effects licorice (Glycyrrhizae) root flavonoids. Suppression mice-recipients degree...
Была изучена сплошная этнически однородная (чуваши) выборка, включающая 30 пациентов с острым коронарным синдромом, поступивших в бюджетное учреждение «Республиканский кардиологический диспансер» Минздрава Чувашской Республики июня по август 2023 г., средний возраст которых составил 64,4 ± 11,6 лет. В день поступления, до оперативного вмешательства все пациенты начинали получать антиагрегантную терапию: клопидогрел или тикагрелор комбинации ацетилсалициловой кислотой. момент поступления...
The article discusses the high relevance of problem inflammatory bowel diseases (IBD). First all, attention is drawn to annual increase in incidence ulcerative colitis and Crohn’s disease. Factors that can influence development IBD are assessed. A diagram pathogenetic cascade dysbiotic disorders presented, manifested by an blood serum metabolic products intestinal microflora, microvascular, immune changes leading triggering inflammation wall.
The gastrointestinal tract is a barrier, represented by dynamic and mutually regulating components (microbial, chemical, physical immune) for the selective penetration of luminal contents into internal environment. From point view immunologists, even in physiological condition, epithelium intestinal wall state mild inflammation, which explained constant invasion antigens (food, microbial) and, turn, readiness immune system to respond.
Introduction: Currently, about 3,000 foreign students study at I.N. Ulyanov Chuvash State University. Globalization of education involves Russian universities into a common global educational space and makes higher more accessible to foreigners. However, moving another country creates stress problem, which affects the quality life health migrant students. Objective: To Indian medical receiving in Republic. Materials methods: A continuous sample first fifth year Medical Faculty was examined...
Introduction. The development and introduction of new drugs with immunomodulatory effects is one the priorities modern medicine. Numerous studies have proven immunotropic activity individual substances isolated from medicinal plants (flavonoids, phenylpropanoids, polysaccharides, ecdysteroids, terpenoids, etc.). In this study, it interest to determine effect Rhaponticum uniflorum (L.) DC. purpose study. Determine properties 20-hydroxyecdysone, 5-О-caffeoylquinic acid arabino-3,6-galactan,...
In order to prevent thromboembolic complications in atrial fibrillation patients with prosthetic heart valves, Warfarin still remains a standard drug real-life clinical practice. However, against the background of therapy, haemorrhage is common; some cases it can be fatal. The reason for this situation lies narrow therapeutic range and wide individual dosage variations drug. Among factors determining effectiveness safety Warfarin, modifiable (for example, interactions, bad habits)...
Since 2020, pathogenetic pharmacotherapy of spinal muscular atrophy in children has been introduced into use the Chuvash Republic. To date, results more than two years using Nusinersen and Risdiplam have accumulated. The aim study was to generalize experience for with an assessment factors determining its effectiveness Materials methods. A retrospective analysis medical records 15 inpatient patients who were treated settings neuropsychiatric department Republican Children's Clinical Hospital...
The incidence of infection after reconstructive plastic surgery on the spine (in particular, spondylodesis) in children remains at a fairly high level and ranges from 0.4% to 8.7%. These complications are often caused by polyresistant bacterial pathogens; this accentuates need for new effective therapeutic approaches. Bacteriophage preparations combination with antibiotics can optimize existing strategies treatment infectious diseases, since they able selectively destroy bacteria, including...