A5012797448- Advanced MRI Techniques and Applications
- Cardiac Imaging and Diagnostics
- Nanoparticle-Based Drug Delivery
- Advanced Neuroimaging Techniques and Applications
- High Altitude and Hypoxia
- Cardiovascular Function and Risk Factors
- MRI in cancer diagnosis
- Cardiomyopathy and Myosin Studies
- Angiogenesis and VEGF in Cancer
- Lanthanide and Transition Metal Complexes
- Characterization and Applications of Magnetic Nanoparticles
- Ultrasound and Hyperthermia Applications
- Radiomics and Machine Learning in Medical Imaging
- Cardiovascular Disease and Adiposity
- bioluminescence and chemiluminescence research
- Mesenchymal stem cell research
- Cardiac electrophysiology and arrhythmias
- Nanoplatforms for cancer theranostics
- Cardiac Ischemia and Reperfusion
- Cardiovascular Effects of Exercise
- Glioma Diagnosis and Treatment
- Barrier Structure and Function Studies
- RNA Interference and Gene Delivery
- Virus-based gene therapy research
- Electron Spin Resonance Studies
West China Hospital of Sichuan University
2016-2025
Sichuan University
2016-2025
Yunnan University
2022-2025
Sichuan Cancer Hospital
2024
University of Electronic Science and Technology of China
2024
Qinghai Provincial Peoples Hospital
2021
West China Medical Center of Sichuan University
2008-2020
Yunnan University of Traditional Chinese Medicine
2020
Chengdu University
2015-2017
Imaging Center
2015
A brain delivery probe was prepared by covalently conjugating lactoferrin (Lf) to a poly(ethylene glycol) (PEG)-coated Fe(3)O(4) nanoparticle in order facilitate the transport of nanoparticles across blood-brain barrier (BBB) receptor-mediated transcytosis via Lf receptor present on cerebral endothelial cells. The efficacy Fe(3)O(4)-Lf conjugate cross BBB evaluated vitro using cell culture model for as well vivo SD rats. For an experiment, well-established porcine used based primary...
Therapeutic outcome for the treatment of glioma was often limited due to low permeability delivery systems across blood–brain barrier (BBB) and poor penetration into tumor tissue. In order overcome these hurdles, we developed dual-targeting doxorubicin liposomes conjugated with cell-penetrating peptide (TAT) transferrin (T7) (DOX-T7-TAT-LIP) transporting drugs BBB, then targeting brain glioma, penetrating tumor. The effects were evaluated by both in vitro vivo experiments. cellular uptake...
The blood-brain barrier (BBB) impedes entry of many drugs into the brain, limiting clinical efficacy. A safe and efficient method for reversibly increasing BBB permeability would greatly facilitate central nervous system (CNS) drug delivery expand range possible therapeutics to include water soluble compounds, proteins, nucleotides, other large molecules. We examined effect vascular endothelial growth factor (VEGF) on in Kunming (KM) mice. Human VEGF165 was administered treatment groups at...
Abstract Epidemiological studies have shown that an elevated uric acid (UA) level predicts the development of metabolic syndrome and diabetes; however, there is no direct evidence this underlying mechanism remains unclear. Here, we showed a high-UA diet triggered expression pro-inflammatory cytokines, activated NF-κB pathway increased gliosis in hypothalamus. Intracerebroventricular injection UA induced hypothalamic inflammation reactive gliosis, whereas these effects were markedly...
Uric acid (UA) is a purine metabolite that in most mammals degraded by the hepatic enzyme uricase to allantoin. Epidemiological studies have shown an elevated UA level predicts development of cognition and memory deficits; however, there no direct evidence this relationship, underlying mechanism largely undefined. Here, we show high-UA diet triggers expression proinflammatory cytokines, activates Toll-like receptor 4 (TLR4)/nuclear factor (NF)-κB pathway, increases gliosis hippocampus Wistar...
Purpose: To use magnetic resonance (MR) imaging and positron emission tomography (PET) dual detection of cardiac-grafted embryonic stem cells (ESCs) to examine (a) survival proliferation ESCs in normal infarcted myocardium, (b) host macrophage versus grafted ESC contribution serial MR signal over time, (c) cardiac function associated with the formation grafts whether improvement is related differentiation ESCs. Materials Methods: All animal procedures were approved by institutional care...
Liver-imaging probes are prepared through the conjugation of Gd chelates and galactosyl moieties to peptide dendrimers. The dendritic possessing highly controlled structures a single molecular weight have two-fold increase in T(1) relaxivity 9.1 x 10(3) (Gd M)(-1) s(-1) compared Gd-DTPA. No obvious cytotoxicity this multifunctional agent is discovered vitro. dendrimer bearing leads much-higher hepatocyte-cell uptake vitro provides good signal-intensity enhancement (35%) mouse liver vivo...
The blood-brain barrier (BBB) protects the central nervous system from external insults by limiting substance diffusion through endothelial interface. presence of BBB makes drug delivery in neurological disorders very challenging. Cisplatin has been shown to be cytotoxic glioma cells, but substantial limitations exist its clinical applications due difficulties penetration across BBB. Here, we show that L-borneol, a messenger widely used traditional Chinese medicine, can induce transient...
Eu-doped GdPO<sub>4</sub> NRs coated by silk fibroin have been prepared in a template of (SF) peptides <italic>via</italic> mineralization process. A growth mechanism SF-NRs is proposed to explain their stronger luminescence, better cyto-compatibility and higher longitudinal relaxivity <italic>r</italic><sub>1</sub>.
Targeting delivery and size-induced deep penetration have been applied in triple-negative breast cancer (TNBC) theranostics.
Abstract Rubiaceae-type cyclopeptides (RAs) are a type of plant from the Rubia that have garnered significant attention owing to their unique bicyclic structures and amazing antitumour activities. Our recent work has shown RAs suppress inflammation angiogenesis induce apoptosis. However, underlying mechanism targets remained unknown. Nuclear factor κB (NF-κB) signaling pathway plays critical role in these biological processes, prompting us investigate whether how affect this pathway. By...
To detect diffuse myocardial fibrosis in different severity levels of left ventricular diastolic dysfunction (DD) spontaneous type 2 diabetes mellitus (T2DM) rhesus monkeys.Eighteen T2DM and nine healthy monkeys were studied. Echocardiography was performed for function classification. Cardiac magnetic resonance (CMR) imaging to obtain extracellular volume fraction (ECV) maps T1ρ at two spin-locking frequencies. ECV values, index (mFI) values which are based on the dispersion T1ρ, calculated....
We aimed to explore the protective effects and potential treatment mechanism of Epigallocatechin-3-gallate (EGCG) in an animal model chronic exposure a natural high-altitude hypoxia (HAH) environment. Behavioral alterations were assessed with Morris water maze test. Iron accumulation hippocampus was detected by using DAB enhanced Perls' staining, MRI, qPCR colorimetry, respectively. Oxidative stress (malondialdehyde, MDA), apoptosis (Caspase-3), neural regeneration (brain-derived...
Atherosclerosis is one of the main risk factors cause acute cerebral-cardio vascular diseases. It's great significance to establish an atherosclerosis animal model that can mimic characteristics and nature course human patients. Therefore, a rhesus monkey was induced by high-fat diet monitor their lipid profile intima-media thickness (IMT) artery walls study progression. Fifty male monkeys were enrolled in this study. All these aged 7 14 years with BMI >30 kg/m2. They fed containing 10% fat...