A5060840634- Plant-derived Lignans Synthesis and Bioactivity
- Cancer, Hypoxia, and Metabolism
- Epigenetics and DNA Methylation
- Phytochemistry and Biological Activities
- Metabolomics and Mass Spectrometry Studies
- Synthesis and biological activity
- Sperm and Testicular Function
- Diet and metabolism studies
- Pancreatic function and diabetes
- Chemical Reactions and Isotopes
- Cancer, Lipids, and Metabolism
- Cancer-related gene regulation
- Pain Mechanisms and Treatments
- Biological Activity of Diterpenoids and Biflavonoids
- Radiomics and Machine Learning in Medical Imaging
- Lung Cancer Diagnosis and Treatment
- Histone Deacetylase Inhibitors Research
- Peptidase Inhibition and Analysis
- Advanced Breast Cancer Therapies
- Neuropeptides and Animal Physiology
- Advanced NMR Techniques and Applications
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Barrier Structure and Function Studies
- Gout, Hyperuricemia, Uric Acid
- RNA regulation and disease
Sichuan University
2015-2025
State Key Laboratory of Biotherapy
2015-2025
West China Hospital of Sichuan University
2023-2025
Massachusetts General Hospital
2022
Harvard University
2022
Nanjing University of Chinese Medicine
2020-2021
Suzhou Traditional Chinese Medicine Hospital
2020-2021
CM Hospital
2020
Nantong University
2009-2013
The Nautical Institute
2010
Abstract Breast carcinoma is the most common female cancer with considerable metastatic potential. Signal transducers and activators of transcription 3 (Stat3) signaling pathway constitutively activated in many cancers including breast has been validated as a novel potential anticancer target. Here, we reported our finding nifuroxazide, an antidiarrheal agent identified potent inhibitor Stat3. The potency nifuroxazide on was assessed vitro vivo . In this investigation, found that decreased...
Gastric cancer is the fourth most common and second deadly worldwide. Study on molecular mechanisms of carcinogenesis will play a significant role in diagnosing treating gastric cancer. Metabolic profiling may offer opportunity to understand mechanism help identify potential biomarkers for early diagnosis In this study, we reported metabolic tissue samples large cohort human subjects (n = 125) normal controls 54) based 1H nuclear magnetic resonance (1H NMR) together with multivariate...
Introduction: Serine hydroxymethyltransferase 2 (SHMT2) plays a critical role in serine-glycine metabolism to drive cancer cell proliferation. However, the nonmetabolic function of SHMT2 tumorigenesis, especially human colorectal (CRC) progression, remains largely unclear. Methods: expression CRC cells was identified by western blot and immunofluorescence assay. The proliferation, migration, invasion after knockdown or overexpression were explored through vitro vivo assays....
Uric acid (UA) is a purine metabolite that in most mammals degraded by the hepatic enzyme uricase to allantoin. Epidemiological studies have shown an elevated UA level predicts development of cognition and memory deficits; however, there no direct evidence this relationship, underlying mechanism largely undefined. Here, we show high-UA diet triggers expression proinflammatory cytokines, activates Toll-like receptor 4 (TLR4)/nuclear factor (NF)-κB pathway, increases gliosis hippocampus Wistar...
Serine metabolism provides important metabolic intermediates that support the rapid proliferation of tumor cells. However, role serine in esophageal squamous cell carcinoma (ESCC) and underlying mechanism remains unclear. Here, we show starvation predominantly inhibits ESCC by suppressing purine nucleotides NADPH synthesis. Mechanistically, depletion led to accumulation aminoimidazole carboxamide ribonucleoside (AICAR), an intermediate metabolite de novo synthesis, AMP/ATP ratio. These...
Accumulating evidence has revealed the anti-inflammatory effects of arbutin against various diseases. However, are not clarified in ulcerative colitis. This study was intended to investigate protective and mechanisms on DSS-induced Hematoxylin eosin staining performed determine pathological damage intestinal tissue mice. Inflammatory factors levels were detected by enzyme linked immunosorbent assay (ELISA) assay. TUNEL showed apoptosis cells. Intestinal permeability analyzed using...
A series of benzoisoindolin hydrazones as analogues natural lignan diphyllin were synthesized and the structures these compounds established by 1H-NMR, 13C-NMR, Mass high resolution (HR)-MS. The evaluated for in vitro cytotoxicity against KB, A549 HCT-116 cancer cell lines 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Compound 4 possessed highest growth inhibitory effect. Significant apoptosis cells treated with compound was observed Hoechst33342-propidium iodide...
A series of quinoline derivatives was synthesized and biologically evaluated as Enhancer Zeste Homologue 2 (EZH2) inhibitors. Structure-activity relationship (SAR) studies led to the discovery 5-methoxy-2-(4-methyl-1,4-diazepan-1-yl)-N-(1-methylpiperidin-4-yl)quinolin-4-amine (5k), which displayed an IC50 value 1.2 μM against EZH2, decreased global H3K27me3 level in cells also showed good anti-viability activities two tumor cell lines. Due low molecular weight fact that no derivative has...
Background: Cancer associated fibroblasts (CAFs) undergo a metabolic reprogramming to support tumor metastasis. However, lipid alterations of CAFs and underlying mechanism in colorectal cancer (CRC) progression remain unclear.Methods: Human normal (NFs) are isolated from fresh CRC samples. The proliferation migration cells detected by MTT assay, Wound-healing Transwell qRT-PCR, Western bolt Immunofluorescent (IF). profiles CAFs, NFs their CM UPLC-Q-TOF/MS based on lipidomic assay. verified...
To investigate the differences in intestinal microbiota between diarrhea irritable bowel syndrome mice (IBS‐D) and healthy to explore effects of Jianpi mixture on microbes’ changes IBS‐D based 16S rDNA sequencing analysis. 48 young ICR male were randomly divided into four groups ( n = 12): (1) control group, (2) group fed with distilled water, (3) lactic acid bacteria compound, (4) for 14 days. At end treatment period, 5 selected from each then before after analyzed by high‐throughput gene...
Abstract Serine metabolism provides important metabolic intermediates that support rapid proliferation of tumor cells. However, the role serine in esophageal squamous cell carcinoma (ESCC) and underlying mechanisms remains unclear. Here, we show starvation predominantly inhibits ESCC by suppressing purine nucleotide NADPH synthesis, which inducing inhibition one-carbon metabolism. Mechanistically, aminoimidazole carboxamide ribonucleoside (AICAR), an intermediate metabolite for de novo...
Background Oligospermia is one of the most common reasons for male infertility which troubling numerous couples child-bearing age. This investigation scrutinizes implications and mechanistic underpinnings ursolic acid’s effect on busulfan-induced oligospermia in mouse models. Methods A singular intraperitoneal injection busulfan at a dosage 30 mg/kg induced oligospermia. Two weeks subsequent to this induction, mice were subjected various dosages acid (10, 30, 50 body weight, respectively)...
Objective Hydroxytyrosol (HT), a polyphenolic component identified in olive oil and leaves, represents one of the most extensively investigated natural phenol due to its diverse beneficial biological properties. Recent studies have shown that HT exhibits protective effects on reproductive function can improve sperm quality. However, precise effect underlying mechanism oligozoospermia remain unclear. This study aims investigate across varying concentrations oligozoospermia. Methods...