A5100377417- X-ray Diffraction in Crystallography
- Inflammasome and immune disorders
- Crystallization and Solubility Studies
- Cancer, Hypoxia, and Metabolism
- Metabolomics and Mass Spectrometry Studies
- Gout, Hyperuricemia, Uric Acid
- Angiogenesis and VEGF in Cancer
- Diet and metabolism studies
- Immunotherapy and Immune Responses
- Receptor Mechanisms and Signaling
- Cancer Research and Treatments
- Virus-based gene therapy research
- Immune Response and Inflammation
- Genetics, Aging, and Longevity in Model Organisms
- Prostate Cancer Treatment and Research
- Heat shock proteins research
- Bipolar Disorder and Treatment
- Connexins and lens biology
- Mass Spectrometry Techniques and Applications
- Plant and Fungal Interactions Research
- Educational Technology and Pedagogy
- Metal-Organic Frameworks: Synthesis and Applications
- Cardiac Ischemia and Reperfusion
- Glycosylation and Glycoproteins Research
- Phosphodiesterase function and regulation
First Affiliated Hospital of Henan University
2022-2025
Soochow University
2025
Henan University
2016-2024
Zhejiang Ocean University
2024
Sichuan University
2012-2016
State Key Laboratory of Biotherapy
2014-2016
Chinese Academy of Agricultural Sciences
2016
Institute of Plant Protection
2016
Centre for Addiction and Mental Health
2014-2015
NLRP3 inflammasome activation plays an important role in diabetic cardiomyopathy (DCM), which may relate to excessive production of reactive oxygen species (ROS). Gypenosides (Gps), the major ingredients Gynostemma pentaphylla (Thunb.) Makino, have exerted properties anti-hyperglycaemia and anti-inflammation, but whether Gps improve myocardial damage mechanism remains unclear. Here, we found that high glucose (HG) induced by activating then promoting IL-1β IL-18 secretion H9C2 cells NRVMs....
Gastric cancer is the fourth most common and second deadly worldwide. Study on molecular mechanisms of carcinogenesis will play a significant role in diagnosing treating gastric cancer. Metabolic profiling may offer opportunity to understand mechanism help identify potential biomarkers for early diagnosis In this study, we reported metabolic tissue samples large cohort human subjects (n = 125) normal controls 54) based 1H nuclear magnetic resonance (1H NMR) together with multivariate...
Two novel double-stranded RNA (dsRNA) mycoviruses, termed Fusarium poae dsRNA virus 2 (FpV2) and 3 (FpV3), were isolated from the plant pathogenic fungus, strain SX63, molecularly characterized. FpV2 FpV3, with respective genome sequences of 9518 9419 base pairs (bps), are both predicted to contain two discontinuous open reading frames (ORFs), ORF1 ORF2. A hypothetical polypeptide (P1) a RNA-dependent polymerase (RdRp) encoded by ORF2, respectively. Phytoreo_S7 domain (pfam07236) homologs...
Abstract Metal halides have recently garnered significant attention in developing functional materials, predominantly utilizing elements with stable isotopes as chemical components. However, the exploration of metal containing radioisotopes remains its infancy, and their potential functionalities are not yet well understood. Herein, synthesis characterization first radionuclide‐doped supramolecular halide that displays unprecedented self‐induced radioluminescence reported. The complex 90...
Purpose: Metformin (Met) is widely used to treat a variety of diseases, but its role in ulcerative colitis (UC) has not been fully elucidated. This study aimed clarify the effect Met on UC, exploring relationship with NLRP3 inflammasome and elucidating potential mechanisms. Methods: C57BL/6J mice were administrated DSS solution establish UC model. Disease Activity Index (DAI) hematoxylin eosin staining (HE) performed evaluate impact Enzyme-linked immunosorbent assay (ELISA), Reverse...
1,25-dihydroxyvitamin D3 (1,25(OH)2 D3, VitD3) is the major active ingredient of vitamin D and has anti-inflammatory activity; however, mechanism for this remains poorly understood. In study, we found that VitD3 was able to abolish NOD-like receptor protein 3 (NLRP3) inflammasome activation subsequently inhibit caspase-1 IL-1β secretion via (VDR). Furthermore, specifically prevented NLRP3-mediated apoptosis-associated speck-like with a caspase-recruitment domain (ASC) oligomerization....
Abstract Uric acid crystal is known to activate the NLRP3 inflammasome and cause tissue damages, which can result in many diseases, such as gout, chronic renal injury myocardial damage. Meanwhile, soluble uric (sUA), before forming crystals, also related these diseases. This study was carried out investigate whether sUA could cardiomyocytes analyse mechanisms. The cardiomyocyte activity monitored, along with levels of mature IL‐1β caspase‐1 from H9c2 cells following stimulus. We found that...
The abnormal activation of NLRP3 inflammasome is related to the occurrence and development ulcerative colitis (UC). However, ideal drug delivery system remain important factors limiting targeting in UC therapy. Gene therapy by delivering siRNA effective treating various diseases. Therefore, siNLRP3 using an vector for treatment necessary.Nanoparticles were developed based on cationic liposome (CLP/siNLRP3). Their ability inhibit was monitored Western blot (WB) Enzyme-linked Immunosorbent...
Prostate cancer (PCa) is a malignant tumor for which there are no effective treatment strategies. In this study, we developed targeted strategy prostate-specific membrane-antigen (PSMA)-positive PCa in vitro based on 2-(3-((S)-5-amino-1-carboxypentyl)ureido) pentanedioic acid (ACUPA) modified polyethylene glycol (PEG)-Cholesterol micelles containing wogonin (WOG), was named ACUPA-M-WOG. ACUPA-M-WOG conventionally prepared using self-assembling method, produced stable particle size and ζ...
Gastric cancer (GC) is a malignant tumor worldwide. As primary pathway for metastasis, the lymphatic system an important prognostic factor GC patients. Although metabolic changes of gastric have been investigated in extensive studies, little effort focused on profiling lymph node metastasis (LNM)-positive or negative We performed 1H NMR spectrum tissue samples with and without LNM to identify novel potential biomarkers process GC. NMR-based untargeted metabolomics approach combined...
Adjuvants are important components of recombinant protein vaccines which often poorly immunogenic. For decades, the search for new vaccine adjuvants has been predominantly empirical. In addition, combinations more than one adjuvant plus antigen have systematically studied. Plasmid DNA containing additional oligodeoxynucleotides with unmethylated CpG motifs (CpG ODN) entrapped in liposomes used as an and shown powerful immunostimulatory functions. our study, combination plasmid 16 ODNs...
Abstract Aim This study aimed to develop and evaluate the efficacy safety of Supine Daoyin, a TCM PR technique, in hospitalized patients with AECOPD. Methods is multicenter, prospective, randomized, controlled trial involving AECOPD inpatients recruited from April 2021 December 2023 five tertiary hospitals China. Participants were randomly assigned 14 days Daoyin group or control evaluated at 3, 7, (posttreatment). The primary outcomes LOS CCQ secondary 6MWD, 30‐STS, BI, Borg CR10, time on...
Long-term polymer flooding exacerbates reservoir heterogeneity, intensifying intra- and inter-layer conflicts, which makes it difficult to recover the remaining oil. Therefore, further improvement in oil recovery after is essential. In this study, a weak gel system was successfully synthesized, possesses distinct network structure that becomes more compact as concentration of partially hydrolyzed polyacrylamide increases. The provides excellent shear resistance, with its apparent viscosity...
Hepatocellular carcinoma (HCC) is a typical hypervascular tumor. Our previous studies have demonstrated that hepatitis B virus X protein (HBx) was able to inhibit the growth of HCC cells via inducing apoptosis and inhibiting tumor angiogenesis. Interleukin-12 (IL-12) disulfide-linked heterodimeric cytokine with potent immunostimulatory activity anti-angiogenic properties. In this study, further investigate regulatory effect IL-12 on HBx-mediated intervention hepatoma microenvironment...
Adeno-associated virus (AAV) is an ideal choice for gene delivery; however, its further development has been limited owing to low transduction efficiency. DNA-damaging agents can improve AAV-mediated transgene expression. Hyperthermia, as one of the oldest documented tumor treatment modalities, cause DNA damage well. However, combined consisting hyperthermia and therapy not reported yet. In this work we investigated whether pigment epithelium-derived factor (PEDF) delivery with synergistic...