A5100672865- Autophagy in Disease and Therapy
- Signaling Pathways in Disease
- Extracellular vesicles in disease
- Ubiquitin and proteasome pathways
- Nanoplatforms for cancer theranostics
- Immune Cell Function and Interaction
- Inflammasome and immune disorders
- Toxin Mechanisms and Immunotoxins
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Erythrocyte Function and Pathophysiology
- Ginseng Biological Effects and Applications
- Bone Metabolism and Diseases
- FOXO transcription factor regulation
- Single-cell and spatial transcriptomics
- SARS-CoV-2 detection and testing
- Plant Gene Expression Analysis
- Galectins and Cancer Biology
- IL-33, ST2, and ILC Pathways
- Biochemical and Structural Characterization
- Invertebrate Immune Response Mechanisms
- Protein Degradation and Inhibitors
- Multiple Myeloma Research and Treatments
- Milk Quality and Mastitis in Dairy Cows
- Histone Deacetylase Inhibitors Research
Second Affiliated Hospital of Nanchang University
2025
Nanchang University
2023-2025
Fujian Agriculture and Forestry University
2025
Zunyi Medical University
2023-2025
Changchun University of Chinese Medicine
2017-2024
Henan University
2018-2024
Shandong University
2023-2024
Dalian Medical University
2024
First Affiliated Hospital of Dalian Medical University
2024
National Cancer Center
2024
Cells release extracellular vesicles (EVs) as the carriers for intercellular communications to regulate life activities. Particularly, it is increasingly apparent that mechanical forces play an essential role in biological systems. The nanomechanical properties of EVs and their dynamics cancer development are still not fully understood. Herein, with use atomic force microscopy (AFM), signatures from liquid biopsies hematologic patients were unraveled. Single native probed by AFM under...
The cancer-associated fibroblast (CAF) barrier in pancreatic ductal adenocarcinoma (PDAC) greatly restricts clinical outcomes. Major obstacles to PDAC treatment include restricted immune cell infiltration and drug penetration the immunosuppressive microenvironment. Here, we reported a "shooting fish barrel" strategy by preparing lipid–polymer hybrid delivery system (PI/JGC/L-A) that could overcome CAF turning it into "barrel" with antitumor depot properties alleviate microenvironment...
Epigallocatechin-3-O-gallate (EGCG) is an important ingredient that indicates tea quality and has healthcare functions. Magnesium nutrition can improve the yield of plants, but its regulatory role in biosynthesis EGCG plants not been clarified. Herein, we performed a comprehensive analysis metabolomics transcriptomics shoots ‘Huangdan’ at five magnesium concentrations: L1-L5 (0, 0.15, 0.45, 0.6, 0.9 mmol/L mg2+, respectively). The results showed content treated with low concentrations was...
The aim of this study was to investigate whether magnesium cantharidate (MC) exerts anti-hepatocellular carcinoma (anti-HCC) effects by targeting receptor for activated C kinase 1 (RACK1). Cancer Genome Atlas (TCGA) database used analyze the expression RACK1 in liver tissues. Molecular docking examine binding interactions between MC and RACK1. Huh-7 SK-Hep-1 cancer cells' viability, proliferation, apoptosis were assessed using Cell Counting Kit-8 (CCK-8) assay, 5-ethynyl-2'-deoxyuridine...
In the course of both innate and adaptive immunity, cytidine deaminases within activation induced deaminase (AID)/apolipoprotein B editing complex (APOBEC) family modulate immune responses by mutating specific nucleic acid sequences hosts pathogens. The evolutionary emergence these mediators, however, seems to coincide precisely with immunity in vertebrates. Here, we show a genes species two divergent invertebrate phyla-the echinoderm Strongylocentrotus purpuratus brachiopod Lingula...
Abstract Uric acid crystal is known to activate the NLRP3 inflammasome and cause tissue damages, which can result in many diseases, such as gout, chronic renal injury myocardial damage. Meanwhile, soluble uric (sUA), before forming crystals, also related these diseases. This study was carried out investigate whether sUA could cardiomyocytes analyse mechanisms. The cardiomyocyte activity monitored, along with levels of mature IL‐1β caspase‐1 from H9c2 cells following stimulus. We found that...
Abstract Tumor immune escape caused by low levels of tumor immunogenicity and checkpoint‐dependent suppression limits the immunotherapeutic effect. Herein, a “two‐way regulation” epigenetic therapeutic strategy is proposed using novel nano‐regulator that inhibits upregulating expression tumor‐associated antigens (TAAs) to improve downregulating programmed cell death 1 ligand (PD‐L1) block death‐1 (PD‐1)/PD‐L1. To engineer nano‐regulator, DNA methyltransferase (DNMT) inhibitor zebularine...
Glioblastoma stem cells (GSCs) are pivotal in the recurrence and drug resistance of glioblastoma multiforme (GBM). However, precision therapeutic diagnostic markers for GSCs have not been fully established. Here, using bioinformatics experimental analysis, we identified P4HB, a protein disulfide isomerase, as serum marker that maintains stemness through Wnt/β-catenin signaling pathway. Transcriptional silencing P4HB induces apoptosis diminishes cell-like characteristics GSCs. Treatments with...
Growth differentiation factor 11 (GDF11) has an anti-inflammatory effect in the mouse model of atherosclerosis and Alzheimer's disease, but how GDF11 regulates intestinal inflammation during ulcerative colitis (UC) is poorly defined. The Nod-like receptor family pyrin domain-1 containing 3 (NLRP3) inflammasome closely associated with because its ability to increase IL-1β secretion. Our aim determine whether on attenuating experimental mice. In this study, using a dextran sodium sulfate...
Abstract Vasculogenic mimicry (VM) is an endothelium-independent tumor microcirculation that provides adequate blood supply for growth. The presence of VM greatly hinders the treatment glioblastoma (GBM) with anti-angiogenic drugs. Therefore, targeting formation may be a feasible therapeutic strategy GBM. research aimed to evaluate roles BUD13, CDK12, MBNL1 in regulating BUD13 and CDK12 were upregulated was downregulated GBM tissues cells. Knockdown or overexpression inhibited formation....
<title>Abstract</title> Glioblastoma (GBM), the most aggressive and treatment-resistant form of brain cancer, is significantly influenced by GBM stem cells (GSCs), which contribute to tumor initiation recurrence. In this study, we introduce two novel proteolysis-targeting chimeras (PROTACs), AN-1 AN-2, engineered degrade BCL-X<sub>L</sub>, a critical anti-apoptotic protein in BCL-2 family. These PROTACs are optimized from ABT-263 uniquely utilize MDM2 as an E3 ligase, strategy not previously...
// Chunyu Zhu 1, * , Fangliang Zheng Junfeng 1 Meichen Liu Na Xue Li Zhang Zaidong Deng Qi Zhao 2, 3 and Hongsheng 2 Key Laboratory of Animal Resource Epidemic Disease Prevention, School Life Science, Liaoning University, Shenyang 110036, China Research Center for Computer Simulating Information Processing Bio-Macromolecules Liaoning, Mathematics, The first two authors should be regarded as joint Correspondence to: Liu, email: liuhongsheng@lnu.edu.cn Keywords: IAV, NS1, NOLC1,...
The incidence of acute myocardial infarction (AMI) is currently increasing. Early detection important for the treatment and prognosis patients with AMI. Heart‑type fatty acid‑binding protein (H‑FABP) may be used as an early marker AMI due to its high sensitivity, specificity prognostic value. Therefore, in present study, H‑FABP was a biomarker double‑antibody sandwich method colloidal gold‑based lateral flow immunoassay develop rapid kit processing time only 5 min. sensitivity plasma whole...
A GTPase binding protein, Ras interacting protein 1 (RASIP1), has been reported with a tumor-promoting role in lung cancer cells, and its lymphoma remains unknown. The analysis of medical databank shows that RASIP1 is upregulated diffuse large B-cell (DLBCL) specimens. In this article, we demonstrated highly expressed DLBCL cell lines, compared primary B cells. gain- loss-of-function experiments were performed to investigate the effects on CCK-8, flow cytometry, western blot, transwell...
Modified Duhuo Jisheng Decoction (MDHJSD) is a traditional Chinese medicine prescription for the treatment of osteoporosis (OP), but its mechanism action has not yet been clarified. This study aims to explore MDHJSD in OP through combination network pharmacology analysis and experimental verification.The active ingredients corresponding targets were acquired from Traditional Medicine System Pharmacology (TCMSP) database. OP-related databases, including Genecards, OMIM, Drugbank, CTD, PGKB....
Cyclophilins (CyPs), a member of peptidyl-prolyl cis-trans isomerases (PPIases), are ubiquitously distributed in organisms such as bacteria, yeast, plants and animals. CyPs have diverse biological functions, with some exhibiting antifungal antiviral activities. In this study, Panax ginseng cyclophilin (pgCyP), novel gene encoding an protein from ginseng, was cloned, its product expressed Escherichia coli, then fractionated by affinity chromatography. The open reading frame the pgCyP...
Background: Among central nervous system tumors, glioblastoma (GBM) is considered to be the most destructive malignancy. Recurrence one of fatal aspects GBM. However, driver molecules that trigger GBM recurrence are currently unclear. Methods: The mRNA expression data and clinical information normal tissues were collected from Chinese Glioma Genome Atlas Cancer (TCGA), REpository for Molecular BRAin Neoplasia DaTa (REMBRANDT) cohorts. DESeq2 R package was used identify differentially...
Abstract Diffuse large B‐cell lymphoma (DLBCL) is difficult to treat due the high recurrence rate and therapy intolerance, so finding potential therapeutic targets for DLBCL critical. FK506‐binding protein 3 (FKBP3) contributes progression of various cancers highly expressed in DLBCL, but role FKBP3 its mechanism are not clear. Our study demonstrated that aggravated proliferation stemness cells, tumour growth a xenograft mouse model. The interaction between parkinsonism associated deglycase...