A5101765032- Ginseng Biological Effects and Applications
- Spectroscopy and Chemometric Analyses
- Autophagy in Disease and Therapy
- Protein Interaction Studies and Fluorescence Analysis
- Food Quality and Safety Studies
- Pharmacological Effects of Natural Compounds
- Agriculture, Soil, Plant Science
- Traditional Chinese Medicine Analysis
- Cancer-related molecular mechanisms research
- Remote Sensing and Land Use
- Surfactants and Colloidal Systems
- Berberine and alkaloids research
- Spectroscopy Techniques in Biomedical and Chemical Research
- Essential Oils and Antimicrobial Activity
- Remote Sensing in Agriculture
- Smart Agriculture and AI
- Drug Transport and Resistance Mechanisms
- Erythrocyte Function and Pathophysiology
- Gold and Silver Nanoparticles Synthesis and Applications
- Paraquat toxicity studies and treatments
- Bone Metabolism and Diseases
- Gene Regulatory Network Analysis
- Biological and pharmacological studies of plants
- Molecular Biology Techniques and Applications
- Botany, Ecology, and Taxonomy Studies
Changchun University of Chinese Medicine
2014-2025
Jilin Normal University
2024
China Agricultural University
2023-2024
Accumulation of amyloid-β (Aβ), which results in the formation senile plaques that cause oxidative damage and neuronal cell death, has been accepted as major pathological mechanism Alzheimer's disease (AD). Hence, inhibition Aβ-induced apoptosis represents effective strategies combating AD. Ginsenoside Re (Re) pharmacological effects against neurotoxicity. However, its molecular remains elusive. The present study evaluated effect cytotoxicity SH-SY5Y cells, investigated underlying mechanism....
Ganoderma lucidum is a widely used medicinal fungus whose quality influenced by various factors, making traditional chemical detection methods complex and economically challenging. This study addresses the need for fast, noninvasive testing combining hyperspectral imaging with machine learning to predict polysaccharide ergosterol levels in cap powder. Hyperspectral images visible near-infrared (385-1009 nm) short-wave infrared (899-1695 ranges were collected, measured high-performance liquid...
20(S)-Ginsenoside Rg3 (GRg3) has various bioactivities including anti-cancer effects and inhibition of autophagy. However, no reports have investigated the appearance autophagy or connection between apoptosis in HeLa cells treated with 20(S)-GRg3. Cell viability was measured by CCK-8 (cell counting kit-8) assays. Apoptosis cell cycle were analyzed Hoechst 33342 staining flow cytometry. Apoptotic pathways examined ROS (reactive oxygen species) determination rhodamine 123 Western blot analysis...
20(S)‑Ginsenoside Rh2 [20(S)‑GRh2], one of the main active components Panax ginseng, induces apoptosis in a wide range cancer cell types. The present study found that 20(S)‑GRh2 reduces mitochondrial membrane potential, decreases adenosine triphosphate generation and reactive oxygen species HeLa cervical cells. In addition, activated mitochondrion‑dependent inhibited both oxidative phosphorylation glycolysis It was voltage‑dependent anion channel 1 (VDAC1) expression significantly...
Deer sinew (DS) has been used traditionally for various illnesses, and the major active constituent is collagen. In this study, we assessed effects of collagen peptide from DS on bone loss in ovariectomized rats. Wister female rats were randomly divided into six groups as follows: sham-operated (SHAM), control (OVX), OVX given 1.0 mg/kg/week nylestriol (OVX + N), 0.4 g/kg/day H), 0.2 (OXV M), 0.1 L), respectively. After 13 weeks treatment, euthanized, body weight, uterine mineral density...
High-affinity, sodium-dependent dicarboxylate transporter (NaDC3) is responsible for transport of Krebs cycle intermediates and may involve in regulation aging life span. Hydropathy analysis predicts that NaDC3 contains 11 or 12 hydrophobic transmembrane (TM) domains. However, the actual membrane topological structure remains unknown. In this study, confocal immunofluorescence microscopy biotinylation epitope-tagged N C termini provide evidence an extracellular terminus intracellular...
Deer antlers have become a valuable model for biomedical research due to the capacities of regeneration and rapid growth. However, molecular mechanism antler growth remains be elucidated. The aim present study was compare explore control exerted by main beam brow tine during growth.The beams tines sika deer were collected from Chinese (Cervus nippon) at stage. Comparative transcriptome analysis conducted using RNA-Seq technology. Differential expression assessed DEGseq package. Functional...
Cancer cells through autophagy-mediated recycling to meet the metabolic demands of growth and proliferation. The steroidal saponin 20(S)-ginsenoside Rh2 effectively inhibits survival a variety tumor cell lines animal models, but effects on autophagy remain elusive.Cell viability was measured by CCK-8 (cell counting kit-8) assays. Apoptosis, ROS generation mitochondrial membrane potential were analyzed flow cytometry. Western blot analyses used determine changes in protein levels. Morphology...
ABSTRACT 20(S)-Ginsenoside Rh2 (GRh2) has various biological activities including anticancer effects. However, no reports have investigated the connection between autophagy and apoptosis in HeLa cells treated with 20(S)-GRh2. In this study, we found that 20(S)-GRh2 suppressed proliferation induced by activating intrinsic apoptotic pathway causing mitochondrial dysfunction. enhanced cell through promoting phosphorylation of AMPK, depressed AKT, mTOR activity. Furthermore, treatment inhibitor...