A5054078532- Osteoarthritis Treatment and Mechanisms
- Bone Metabolism and Diseases
- Cancer-related molecular mechanisms research
- Spine and Intervertebral Disc Pathology
- Bone health and osteoporosis research
- Inflammatory mediators and NSAID effects
- Spinal Fractures and Fixation Techniques
- Scoliosis diagnosis and treatment
- MicroRNA in disease regulation
- RNA Research and Splicing
- Vitamin D Research Studies
- Rheumatoid Arthritis Research and Therapies
- Cervical and Thoracic Myelopathy
- TGF-β signaling in diseases
- Folate and B Vitamins Research
- Estrogen and related hormone effects
- Trace Elements in Health
- Animal Virus Infections Studies
- interferon and immune responses
- Metabolomics and Mass Spectrometry Studies
- Pharmacological Effects of Medicinal Plants
- Liver Disease Diagnosis and Treatment
- Traditional Chinese Medicine Studies
- Peroxisome Proliferator-Activated Receptors
- Musculoskeletal pain and rehabilitation
Changchun University of Chinese Medicine
2011-2025
Changchun University
2013-2024
The Affiliated Hospital to Changchun University of Chinese Medicine
2011-2023
Weatherford College
2022
Zhejiang Marine Fisheries Research Institute
2019
Zhejiang Shuren University
2019
Second People's Hospital of Yunnan Province
2014
Capital Medical University
1999
The small, heavily glycosylated protein CD24 is primarily expressed by many immune cells and highly mostly in cancer cells. As one of the most crucial biomarkers cancers, frequently solid tumors, while tumor-associated macrophages express Siglec-10 at high levels, can interact on innate to lessen inflammatory responses a variety disorders. Inhibiting inflammation brought SHP-1 and/or SHP-2 phosphatases as well cell phagocytosis macrophages, binding prevent toll-like receptor-mediated...
Background Osteoporosis has already been a growing health concern worldwide. The influence of living area, lifestyle, socioeconomic, and medical conditions on the occurrence osteoporosis in middle-aged elderly people China not fully addressed. Methods study was multicenter cross-sectional permanent residents, which gathered information 22,081 residents from June 2015 to August 2021 seven representative regions China. bone mineral density lumbar vertebrae hip were determined using dual-energy...
Abstract Osteoarthritis (OA) is the most common degenerative joint disorder that causes disability in aged individuals, caused by functional and structural alterations of knee joint. To investigate whether metabolic drivers might be harnessed to promote cartilage repair, a liquid chromatography–mass spectrometry (LC–MS) untargeted metabolomics approach was carried out screen serum biomarkers osteoarthritic rats. Based on correlation analyses, α-ketoglutarate (α-KG) has been demonstrated have...
Glioblastoma is the most aggressive cerebral gliomas. Despite advances in therapies, prognosis still very poor. Therefore, novel therapeutic strategies are required. As a proteasome inhibitor, bortezomib has shown its efficacy as an active antitumor agent against variety of tumors. However, inhibition activity leads to cell death and also induces autophagy, due dual roles autophagy survival tumor cells, effect on glioblastoma cells remains be explored. We therefore assessed whether capable...
Knee osteoarthritis (KOA) is a persistent degenerative condition characterized by the deterioration of cartilage. The Chinese herbal formula Radix Rehmanniae Praeparata- Angelica Sinensis-Radix Achyranthis Bidentatae (RAR) has often been used in effective prescriptions for KOA as main functional drug, but its underlying mechanism remains unclear. Therefore, network pharmacology and verification experiments were employed to investigate impact mode action RAR treatment KOA.
Prospective radiographic study.To investigate the feasibility of controlling quality reconstructed sagittal balance for imbalance.Patients with imbalance cannot walk or stand erect without overwork musculature because compromised biomechanical advantage. The result is muscle fatigue and activity-related pain. During reconstructive surgery, restoration optimal crucial obtaining satisfactory clinical results. However, there no way to control before during surgery.A method was developed...
Oxidative stress is increasingly recognized as a risk factor associated with the development and progression of osteoporosis. Fufang Lurong Jiangu Capsule (FLJC) has known anti-osteoporotic effect, but its pharmacological effect on osteoblasts not clearly understood. This study was designed to investigate FLJC effects/mechanisms in vitro hydrogen peroxide (H2O2)-induced oxidative damage vivo lipopolysaccharide (LPS)-induced mice bone loss. alleviates osteoporosis via unknown mechanisms....
Retrospective radiographic review.To evaluate the outcome of selective thoracic fusion (STF) by using cantilever bending technique (CBT) and direct vertebral rotation (DVR) for major thoracic-compensatory lumbar (MTCL) curves selected new curve criteria, which are broader than Lenke criteria STF.Surgical treatment MTCL aims to maximize number that can be treated with STF optimize instrumented spontaneous correction. Comparing current guidelines shows surgical utilized may affect successful...
Eucommia leaves are dry of ulmoides which have long been considered as a functional health food for the treatment hypertension, hypercholesterolemia, fatty liver, and osteoporosis. With recent development Chinese medicine, widely used tonifying kidneys strengthening bone. However, specific molecular mechanism bone remains largely unknown. Osteoblasts main cells formation; thus, it is essential to study effect on osteoblasts better understand their action. In present study, we prepared an...
Deer antler is considered as a precious traditional Chinese medicinal material and has been widely used to reinforce kidney's yang, nourish essence, strengthen bone function. The most prominent bioactive components in deer are water-soluble proteins that play potential roles formation repair. aim of this study was explore the molecular control therapeutic targets extract (DAE) on articular cartilage.
Abstract Background Deer antler is a traditional Chinese medicine with the function of tonifying kidney and strengthening bone, which often used to treat orthopedic diseases. Methods Eight-week-old C57BL/6 mice were as fixation model open tibial fracture intramedullary nail. The treated deer extract (DAE) or PBS by oral gavage once daily. samples collected performed tissue analysis, including X-ray, micro-CT, histology, qRT-PCR, immunohistochemistry. MC3T3-E1 cells detect effect on ability...
DNA self-assembled nanostructures have been considered as effective vehicles for biomolecule delivery because of their excellent biocompatibility, cellular permeability, noncytotoxicity, and small size. Here, we report an efficient antiviral strategy with tetrahedral framework nucleic acids (tFNAs) delivering interfering RNA (t-siRNA) to silence classical swine fever virus (CSFV) gene in porcine host cells. In this study, two previously reported siRNAs, C3 C6, specifically targeting the CSFV...
Abstract Background The present study investigated the prevalence of osteoporosis (OP) among patients with essential hypertension (EH) in Changchun community and analysed correlation between EH OP. Methods included 425 subjects age- sex-matched healthy controls. Bone mineral density (BMD) serum creatinine (CR) levels were measured, subjects' current OP statuses surveyed to analyse Results group exhibited lower BMD a higher rate having than control group, this difference was statistically...
Cuproptosis is a novel form of cell death, mediated by protein lipid acylation and highly associated with mitochondrial metabolism, which regulated in the cell. Ulcerative colitis (UC) chronic inflammatory bowel disease that recurs frequently, its incidence increasing worldwide every year. Currently, growing number studies have shown cuproptosis-related genes (CRGs) play crucial role development progression variety tumors. However, regulatory CRGs UC has not been fully elucidated. Firstly,...
Deer antlers have become a valuable model for biomedical research due to the capacities of regeneration and rapid growth. However, molecular mechanism antler growth remains be elucidated. The aim present study was compare explore control exerted by main beam brow tine during growth.The beams tines sika deer were collected from Chinese (Cervus nippon) at stage. Comparative transcriptome analysis conducted using RNA-Seq technology. Differential expression assessed DEGseq package. Functional...
Deer velvet antlers are the young horns of male deer that not ossified and densely overgrown. Velvet antler its preparations have been widely used in treatment postmenopausal osteoporosis (PMOP) recent years, although mechanism action human body remains unclear. To screen effective ingredients targets PMOP using network pharmacology to explore potential mechanisms such treatments, we screened active BATMAN-TCM database. We also relevant GeneCards OMIM databases then compared at intersection...