A5100409650- Osteoarthritis Treatment and Mechanisms
- Extracellular vesicles in disease
- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- Bone Metabolism and Diseases
- Bone health and treatments
- MicroRNA in disease regulation
- Kruppel-like factors research
- Glycosylation and Glycoproteins Research
- Inflammasome and immune disorders
- Seaweed-derived Bioactive Compounds
- X-ray Diffraction in Crystallography
- Escherichia coli research studies
- Polysaccharides and Plant Cell Walls
- interferon and immune responses
- Parathyroid Disorders and Treatments
- Chronic Myeloid Leukemia Treatments
- Genetics and Neurodevelopmental Disorders
- Temporomandibular Joint Disorders
- Biofuel production and bioconversion
- Connective tissue disorders research
- Ferroptosis and cancer prognosis
- Genetic Syndromes and Imprinting
- Metabolomics and Mass Spectrometry Studies
- Peroxisome Proliferator-Activated Receptors
Changchun University of Chinese Medicine
2018-2025
Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine
2022
Chinese Institute for Brain Research
2022
Beijing University of Chinese Medicine
2022
Jiangsu Vocational College of Medicine
2022
Kunming Medical University
2022
Affiliated Hospital of Youjiang Medical University for Nationalities
2020-2021
Frederick National Laboratory for Cancer Research
2021
National Cancer Institute
2021
Center for Cancer Research
2021
The fruit of Schisandra chinensis has been used in the traditional Chinese medicine for thousands years. Accumulating evidence suggests that Schisandrin B (Sch B) cardioprotection effect on myocardial ischemia vitro. However, it is unclear whether Sch beneficial effects continuous vivo. aim present study was to investigate could improve cardiac function and attenuate remodeling after infarction (MI) mice. Mice model MI established by permanent ligation left anterior descending (LAD) coronary...
There is compelling evidence that FoxP3+ regulatory T cells (Tregs) play a critical role in promoting tumor immune evasion. Our prior research demonstrated the expression of miR-125b-5p directly inhibits Tregs by targeting TNFR2 and FoxP3. Given significant therapeutic potential mesenchymal stromal/stem cell (MSC)-derived exosomes (MSC-EXO) cancer treatment, MSC-EXO augmenting anti-tumor immunotherapy through delivery remains unexplored. Nanoparticle tracking analysis (NTA) transmission...
Fe<sub>3</sub>O<sub>4</sub>@PANI can be utilized in efficiently enriching intact <italic>N</italic>-glycopeptides from complex biological samples based on hydrogen bond and electrostatic adsorption between glycopeptides this bifunctional nanomaterial.
Objective: To investigate the efficiency and potential mechanisms of exosomes from dendritic cells (DCs) transfected with Forkhead box protein P3 (FOXP3) in development experimental autoimmune encephalomyelitis (EAE). Method: Mouse bone marrow-derived immature DCs were loaded adenovirus carrying FOXP3 gene, generated. Then (FOXP3-EXOs) co-cultured CD4+T cell vitro to evaluate their on proliferation differentiation, injected into EAE mice assess effects EAE. Result: FOXP3-EXOs effective...
Guzhi Zengsheng Zhitongwan (GZZSZTW) is an effective formula of traditional Chinese herbal medicine and has been widely applied in the treatment joint diseases for many years. The aim this study was to dissect molecular targets signaling pathways based on analysis serum proteomics.The herbs GZZSZTW were immersed 5 l distilled water boiled with reflux extraction method. extract filtered, concentrated freeze-dried. chemical profile determined by high-performance lipid chromatography (HPLC)....
Polysaccharides (DAI-1 and DAI-2) from Dipsacus asperoides (D. asperoides) were obtained using mixed-bed ion exchange resin Sephadex G-50 column chromatography following which their properties, structures, activities investigated. The results showed that DAI-1 DAI-2 homogeneous in nature, with glucose the only constituent, had molecular masses of 17 4 kDa, respectively. Methylation analysis indicated backbones mainly composed (1→6)-linked residues. possessed a small number side chains branch...
Realgar is a mineral Chinese medicine, which has been used in China for thousands of years. A well-known truth that the quality traditional medicines basis their efficacious and reliable roles clinical use, principally determined by elements including location production inner inorganic composition. However, there are few studies on control at present. Colon cancer, severe malignant tumor, known to have poor prognosis due high rate metastasis. So far, effects against colon cancer not yet...
<title>Abstract</title> Background There is compelling evidence that FoxP3<sup>+</sup> regulatory T cells (Tregs) play a critical role in promoting tumor immune evasion. Our prior research demonstrated the expression of miR-125b-5p directly inhibits Tregs by targeting TNFR2 and FoxP3. Given significant therapeutic potential mesenchymal stem cell-derived exosomes (MSC-EXO) cancer treatment, MSC-EXO augmenting anti-tumor immunotherapy through delivery remains unexplored. Methods Nanoparticle...
X-box-binding protein 1 (XBP1) is a containing the basic leucine zipper structure. It belongs to cAMP-response element binding (CREB)/activating transcription factor family. As main factor, spliced XBP1 (XBP1s) participates in many physiological and pathological processes plays an important role embryonic development. Previous studies showed that XBP1-knockout mice died because of pancreatic exocrine function deficiency, indicating However, exact development remains unclear. This study aimed...