A5100633771- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Apelin-related biomedical research
- Pectus Deformity Diagnosis and Treatment
- Cancer-related gene regulation
- Congenital Diaphragmatic Hernia Studies
- Birth, Development, and Health
- Gastrointestinal disorders and treatments
- Peptidase Inhibition and Analysis
- Tissue Engineering and Regenerative Medicine
- Heat shock proteins research
- Urological Disorders and Treatments
- Circular RNAs in diseases
- DNA and Nucleic Acid Chemistry
- Drug Transport and Resistance Mechanisms
- Cancer, Hypoxia, and Metabolism
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Mycobacterium research and diagnosis
- Video Coding and Compression Technologies
- Advanced Data Compression Techniques
- Pregnancy and preeclampsia studies
- Galectins and Cancer Biology
- Acute Ischemic Stroke Management
- Neonatal Respiratory Health Research
Eye & ENT Hospital of Fudan University
2023-2025
Qinghai Red Cross Hospital
2023-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2013-2025
Shanghai Clinical Research Center
2025
Nanjing Medical University
2009-2024
Tianjin Medical University Cancer Institute and Hospital
2020-2024
Yancheng Third People's Hospital
2024
University of Oklahoma Health Sciences Center
2018-2024
Jiangsu Province Hospital
2018-2022
Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital
2011-2022
Abstract Background Mitophagy is closely related to the regulation of retinal ganglion cell (RGC) structure and function. Our previous study suggested that long noncoding RNAs (lncRNAs) can cause damage myopic RGCs. However, whether electroacupuncture (EA) treatment delay myopia progression through lncRNA-mediated mitophagy in RGCs currently unknown. This aimed investigate effect EA on Methods investigated modulatory guinea pigs with form-deprived (FDM). RNA sequencing was performed further...
Abstract Background Psychosocial functioning is poor in patients with pectus excavatum (PE). However, a comprehensive understanding of this issue does not exist. The aim study was to assess the severity psychosocial problems as associated PE, well identify its risk factors. Methods A comparative performed at Sichuan Academy Medical Sciences/Sichuan Provincial People's Hospital Chengdu, China. Patients age 6 16 who admitted outpatient department for evaluation or treatment PE were included...
Background: Atherosclerosis (AS) is a major risk factor for cardiovascular disease. microRNAs play key role in gene regulation the formation and development of atherosclerotic plaques. Herein, target miR-185 AS were explored.Materials methods: Cell viability, migration invasion examined by cell counting kit-8 (CCK-8) transwell assay. The relative luciferase activity was measured reporter levels miR-185, STIM1, vascular endothelial growth (VEGF) matrix metalloprotein-9 (MMP-9) evaluated...
Tetraspanin CD151 is highly expressed in endothelia and reinforces cell adhesion, but its role vascular inflammation remains largely unknown.
The multiple gas mixtures in the deck depression chamber (DDC) serves as a life-sustaining medium for divers to adapt high-pressure environments and safely decompress after saturation diving operations....
Oxidative stress serves a key role in doxorubicin (DOX)‑induced cardiotoxicity. The peptide Szeto‑Schiller (SS)31 is an efficacious antioxidant with the capacity to reduce mitochondrial reactive oxygen species (ROS) levels and scavenge free radicals. Although SS31 involved pathophysiological process of various cardiovascular diseases, DOX‑induced cardiotoxicity remains unclear. To explore effects cardiotoxicity, present study first constructed models, which H9c2 cells were incubated 1 µM DOX...
<sec><strong>Objective</strong>Systemic chemotherapy has limited efficacy in the treatment of peritoneal metastasis (PM) gastric cancer (GC). Hyperthermic intraperitoneal (HIPEC) combined with complete cytoreductive surgery (CRS) shown promising outcomes but remains controversial. The present study aimed to evaluate safety and HIPEC without CRS GC patients PM.</sec><sec><strong>Methods</strong>This retrospective propensity score-matched multicenter cohort included PM treated either alone (Cx...
Recent studies have revealed that exercise has myocardial protective effects, but the exact mechanism remains unclear. Studies increasingly found peptides play a role in ischaemia-reperfusion (I/R) injury. However, little is known about of exercise-induced I/R To elucidate effect peptide EIP-22 injury, we first determined on hypoxia/reperfusion (H/R)- or H2 O2 -induced injury via assessing cell viability and lactate dehydrogenase (LDH) level. In addition, reactive oxygen species (ROS)...
Increasing evidence revealed that apoptosis and oxidative stress injury were associated with the pathophysiology of doxorubicin (DOX)-induced myocardial injury. ELABELA (ELA) is a newly identified peptide 32 amino acids, can reduce hypertension exogenous infusion. However, effect 11-residue furn-cleaved fragment (ELA-11) still unclear. We first administrated ELA-11 in DOX-injured mice measured cardiac function investigated vivo . found alleviated heart induced by DOX inhibited tissues from...
In previous studies, we have demonstrated that long noncoding RNA uc.4 may influence the cell differentiation through TGF-β signaling pathway, suppressed heart development of zebrafish and resulting cardiac malformation. DNA methylation plays a significant role in disordered cause disruption control gene promoter. this study, methylated immunoprecipitation was performed to identify different expression levels regions. Gene Ontology Kyoto Encyclopedia Genes Genomes (KEGG) analysis were also...
Heart failure (HF) induced by ischemia myocardial infarction (MI) is one of the major causes morbidity and mortality all around world.Atorvastatin, a hydroxymethylglutaryl coenzyme A reductase inhibitor, has been demonstrated to benefit patients with ischemic or non-ischemicinduced HF, but mechanism still poorly understood.Increasing evidence indicates that lncRNAs play important role in variety human disease.However, underlying molecular mechanisms remain largely unclear.In our work, we...
Intrahepatic cholangiocarcinoma (ICC) can invade and metastasize. EIF5A2 is involved in the invasive metastatic process of several digestive malignancies. However, its role ICC yet to be elucidated. Immunohistochemistry (IHC) Western blot (WB) were used detect level tumor specimens patients evaluate correlation between expression clinicopathological characteristics. The significance prognosis was further evaluated by Kaplan-Meier Cox regression analysis. In addition, CCK-8, EdU, Transwell...
Self-expandable metallic stents (SEMSs) have been recommended for patients with unresectable malignant biliary obstruction while radiation-emitting (REMSs) loaded 125I seeds recently approved to provide longer patency and overall survival in tract obstruction. This trial is evaluate the efficacy safety of REMS plus hepatic arterial infusion chemotherapy (REMS-HAIC) versus SEMS HAIC (SEMS-HAIC) perihilar cholangiocarcinoma (pCCA).