A5087548970- Nerve injury and regeneration
- Neonatal and fetal brain pathology
- Neurogenesis and neuroplasticity mechanisms
- Spinal Cord Injury Research
- Mesenchymal stem cell research
- Neuroinflammation and Neurodegeneration Mechanisms
- Mitochondrial Function and Pathology
- Traumatic Brain Injury and Neurovascular Disturbances
- MicroRNA in disease regulation
- Neurological Disease Mechanisms and Treatments
- Anesthesia and Neurotoxicity Research
- Pain Mechanisms and Treatments
- Alzheimer's disease research and treatments
- Acupuncture Treatment Research Studies
- Anesthesia and Pain Management
- S100 Proteins and Annexins
- Medicinal Plants and Bioactive Compounds
- Spine and Intervertebral Disc Pathology
- RNA Interference and Gene Delivery
- Healthcare and Venom Research
- Domain Adaptation and Few-Shot Learning
- Neonatal Respiratory Health Research
- Cancer-related molecular mechanisms research
- Pluripotent Stem Cells Research
- Cardiac Ischemia and Reperfusion
Sichuan University
2016-2025
West China Hospital of Sichuan University
2016-2025
Zunyi Medical University
2021-2025
State Key Laboratory of Biotherapy
2015-2025
First People’s Hospital of Zunyi
2025
Southwest Medical University
2023-2025
Kunming Medical University
2015-2024
Gannan Normal University
2011-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
Jinzhou Medical University
2021-2024
Abstract In recent years, biomarkers have been integrated into the diagnostic process and become increasingly indispensable for obtaining knowledge of neurodegenerative processes in Alzheimer’s disease (AD). Peripheral blood mononuclear cells (PBMCs) human reported to participate a variety activities. Here, single-cell RNA sequencing analysis PBMCs from 4 AD patients (2 early stage, 2 late stage) normal controls was performed explore differential cell subpopulations patients. A significant...
Abstract Introduction Self‐repair of spinal cord injury (SCI) has been found in humans and experimental animals with partial recovery neurological functions. However, the regulatory mechanisms underlying spontaneous locomotion after SCI are elusive. Aims This study was aimed at evaluating pathological changes injured exploring possible mechanism related to recovery. Results Immunofluorescence staining performed detect GAP43 expression lesion site transection (SCT) rats. Then RNA sequencing...
Abstract Mitochondrial dysfunction is an early feature of Alzheimer's disease (AD). Accumulated damaged mitochondria, which are associated with impaired mitophagy, contribute to neurodegeneration in AD. We show levels Disrupted‐in‐schizophrenia‐1 (DISC1), genetically psychiatric disorders and AD, decrease the brains AD patients transgenic model mice Aβ‐treated cultured cells. contains a canonical LC3‐interacting region (LIR) motif ( 210 FSFI 213 ), through DISC1 directly binds LC3‐I/II....
Abstract Glycosylation is currently considered to be an important hallmark of cancer. However, the characterization glycosylation-related gene sets has not been comprehensively analyzed in glioma, and relationship between genes glioma prognosis elucidated. Here, we firstly found that differentially expressed patients were engaged biological functions related progression revealed by enrichment analysis. Then seven glycosylation ( BGN , C1GALT1C1L GALNT13 SDC1 SERPINA1 SPTBN5 TUBA1C )...
Traumatic brain injury (TBI) induces inflammations that lead to secondary damage. Hesperetin (Hes) exerts anti-inflammatory activities against central nervous system (CNS) diseases. This article probes the possible neuroprotective effect and mechanism of Hes on TBI-induced acute cerebral damage.Male C57BL/6J mice were subjected controlled cortical impingement (CCI) (50 mg/kg) treatment after surgery. Short-term neurological deficits assessed with modified severity score (mNSS) Rota-rod test....
We sought to investigate the effects of co-grafting neural stem cells (NSCs) with olfactory ensheathing (OECs) on neurological behavior in rats subjected traumatic brain injury (TBI) and explore underlying molecular mechanisms. TBI was established by percussion device made through a weight drop (50 g) from 30 cm height. Cultured NSCs OECs isolated were labeled Hoechst 33342 (blue) chloromethyl-benzamidodialkyl carbocyanine (CM-Dil) (red), respectively. Then, and/or OECs, separately or...
Neuronal apoptosis is important pathological change in neonatal hypoxic-ischemic brain damage (HIBD), while the role of miR-7a-2-3p regulation HIBD remains to be unknown. The purpose this study explore mechanism injury and provide theoretical basis for clinical target therapy. Firstly, we established HI model verified with Zealonga scores MRI. Next, changes were screened ischemic cortex by qRT-PCR at 12h,48h 96h after rats. Then, OGD pc12 cells, sy5y cells neurons vitro. Moreover, was used...
Abstract Neonatal hypoxic–ischemic (HI) injury derived from asphyxia during perinatal period, is a serious complication of neonatal and the main cause acute death chronic neurological injury. Aberrant autophagy occurs in many nervous system diseases, but its role underlying mechanism HI largely unknown. Here, we successfully constructed newborn rat model brain injury, knockout-miR-127-3p (KO-miR-127-3p) rats were structured by using CRISPR/Cas9. Subsequently, vitro functional experiments,...
ABSTRACT Aims Neuropathic pain (NP) is a debilitating condition characterized by chronic resulting from nerve damage or lesion. Despite the ongoing efforts of clinically defining NP, its distinctive mechanisms that lead to various NP phenotypes remain unresolved. Methods Using spared injury (SNI) model, we investigated underlying development caused in peripheral nerves. With CRISPR‐Cas9‐mediated knockout and virus‐mediated overexpression strategies, role LncRNA Vof16 (abbreviated as Vof16)...
The tree shrew brain has garnered considerable attention due to its remarkable similarities human brain. However, the cellular composition and genetic signatures of hippocampus across postnatal life remain poorly characterized. Here, we establish first single-nucleus transcriptomic atlas spanning life, detailing dynamics diversity neurogenic lineage, oligodendrocytes, microglia, endothelial cells. Notably, cross-species comparison among humans, macaques, shrews, mice reveals that...
ABSTRACT The lack of natural aging‐inducing Alzheimer's disease (AD) model presents a significant gap in the current preclinical research. Here, we identified unique cohort 10 naturally aging tree shrews (TSs) displaying distinct Alzheimer's‐like pathology (ALP) from population 324, thereby establishing novel that closely mirrors human AD progression. Using single‐nucleus RNA sequencing, generated comprehensive transcriptome atlas, revealing cellular diversity and gene expression changes...
Abstract Neuroregeneration and apoptosis are two important pathophysiologic changes after spinal cord injury (SCI), but their underlying mechanisms remain unclear. MicroRNAs (miRNAs) play a crucial role in the regulation of neuroregeneration neuronal apoptosis, research areas that have been greatly expanded recent years. Here, using miRNA arrays to profile transcriptomes, we demonstrated miR-127-3p was significantly down-regulated transection (SCT). Then, bioinformatics analyses experimental...
Cytochrome c oxidase subunit Va (COX5A) is involved in maintaining normal mitochondrial function. However, little known on the role of COX5A development and progress Alzheimer's disease (Martinez-Losa et al., 2018). In this study, we established characterized genomic profiles genes expressed hippocampus Senescence-Accelerated Mouse-prone 8 (SAMP8) mice, revealed differential expression among 12-month-aged SAMP8 mice 2-month-aged mice. Newly transgenic with systemic overexpression (51%...
Abstract Dysfunctions of ATP-binding cassette, subfamily D, member 1 (ABCD1) cause X-linked adrenoleukodystrophy, a rare neurodegenerative disease that affects all human tissues. Residing in the peroxisome membrane, ABCD1 plays role translocation very long-chain fatty acids for their β-oxidation. Here, six cryo-electron microscopy structures four distinct conformational states were presented. In transporter dimer, two transmembrane domains form substrate pathway, and nucleotide-binding site...
Currently, the treatment of Alzheimer's disease (AD) is still at stage symptomatic due to lack effective drugs. The research on miracle fruit seeds (MFSs) has focused lipid-lowering and antidiabetic effects, but no therapeutic effects have been reported in AD. purpose this study was provide data resources a potential drug for An AD mouse model established treated with MFSs 1 month. Morris water maze test used assess learning memory function mice. Nissl staining demonstrate histopathological...