A5100379281- Cancer-related molecular mechanisms research
- Plant Molecular Biology Research
- Circular RNAs in diseases
- MicroRNA in disease regulation
- RNA modifications and cancer
- Soybean genetics and cultivation
- Plant nutrient uptake and metabolism
- Plant Stress Responses and Tolerance
- Plant Gene Expression Analysis
- Plant Reproductive Biology
- Plant Disease Resistance and Genetics
- Photosynthetic Processes and Mechanisms
- Plant and Fungal Interactions Research
- Legume Nitrogen Fixing Symbiosis
- Nitrogen and Sulfur Effects on Brassica
- Plant Virus Research Studies
- Genomics and Phylogenetic Studies
- Research in Cotton Cultivation
- Plant tissue culture and regeneration
- Ferroptosis and cancer prognosis
- RNA Research and Splicing
- Chromosomal and Genetic Variations
- Plant Physiology and Cultivation Studies
- Nematode management and characterization studies
- Kruppel-like factors research
University of Minnesota System
2025
Jilin Agricultural University
2024-2025
Chinese Academy of Agricultural Sciences
2015-2025
Sun Yat-sen University
2017-2025
Ministry of Agriculture and Rural Affairs
2020-2025
State Key Laboratory of Oncology in South China
2017-2025
Sun Yat-sen University Cancer Center
2017-2025
Central China Normal University
2020-2025
Guangzhou University of Chinese Medicine
2025
Agricultural Information Institute
2025
Summary A large number of noncoding circular RNA s (circ s) with regulatory potency have been identified in animals, but little attention has given to plant circ s. We performed genome‐wide identification Oryza sativa and Arabidopsis thaliana using publically available ‐Seq data, analyzed compared features animal (12037 6012) were , respectively, 56% (10/18) the sampled rice exonic validated experimentally. Parent genes over 700 orthologues between suggesting conservation plants. The introns...
Flowering is an indication of the transition from vegetative growth to reproductive and has considerable effects on life cycle soya bean (Glycine max). In this study, we employed CRISPR/Cas9 system specifically induce targeted mutagenesis GmFT2a, integrator in photoperiod flowering pathway bean. The cultivar Jack was transformed with three sgRNA/Cas9 vectors targeting different sites endogenous GmFT2a via Agrobacterium tumefaciens-mediated transformation. Site-directed mutations were...
Barnyardgrass (Echinochloa crus-galli) is a pernicious weed in agricultural fields worldwide. The molecular mechanisms underlying its success the absence of human intervention are presently unknown. Here we report draft genome sequence hexaploid species E. crus-galli, i.e., 1.27 Gb assembly representing 90.7% predicted size. An extremely large repertoire genes encoding cytochrome P450 monooxygenases and glutathione S-transferases associated with detoxification found. Two gene clusters...
Flowering time is a key agronomic trait that directly influences the successful adaptation of soybean (Glycine max) to diverse latitudes and farming systems. GmFT2a GmFT5a have been extensively identified as flowering activators integrators in soybean. Here, we two quantitative loci (QTLs) regions harbouring GmFT5a, respectively, associated with different genetic effects on under photoperiods. We analysed transgenic plants overexpressing or ft2a mutants, ft5a mutants ft2aft5a double long-day...
Recent genome-wide studies have revealed that the majority of mouse genome is transcribed as non-coding RNAs (ncRNAs) and growing evidence supports importance ncRNAs in regulating gene expression epigenetic processes. However, low efficiency conventional targeting strategies has hindered functional study vivo, particularly generating large fragment deletions long (lncRNAs) with multiple variants. The bacterial clustered regularly interspaced short palindromic repeats...
Yellow seed is a desirable quality trait of the Brassica oilseed species. Previously, several coat color genes have been mapped in species, but molecular mechanism still unknown. In present investigation, map-based cloning method was used to identify gene, located on A9 B. rapa. Blast analysis with Arabidopsis genome showed that there were 22 this region including at4g09820 at4g10620. Functional complementation test exhibited phenotype reversion thaliana tt8-1 mutant and yellow-seeded plant....
Geese were domesticated over 6,000 years ago, making them one of the first poultry. are capable rapid growth, disease resistance, and high liver lipid storage capacity, can be easily fed coarse fodder. Here, we sequence analyze whole-genome an economically important goose breed in China compare it with that terrestrial bird species.A draft whole-goose genome was obtained by shotgun sequencing, 16,150 protein-coding genes predicted. Comparative genomics indicate significant differences occur...
Flowering time is a critical determinant of the geographic distribution and regional adaptability soybean (Glycine max) strongly regulated by photoperiod temperature. In this study, quantitative trait locus (QTL) mapping subsequent candidate gene analysis revealed that GmPRR37, encoding pseudo-response regulator protein, responsible for major QTL qFT12-2, which was identified from population 308 recombinant inbred lines (RILs) derived cross between very late-flowering cultivar,...
Soybean flowering and maturation are strictly regulated by photoperiod. Photoperiod-sensitive soybean varieties can undergo reversion when switched from short-day (SD) to long-day (LD) conditions, suggesting the presence of a 'floral-inhibitor' under LD conditions. We combined gene expression profiling with study transgenic plants confirmed that GmFT1a, Flowering Locus T (FT) homolog, is floral inhibitor. GmFT1a expressed specifically in leaves, similar flowering-promoting FT homologs...
Multiple myeloma (MM) is the second most common hematological cancer all over world. Long non-coding RNA (lncRNA) colon associated transcript-1 (CCAT1) has been reported to play important roles in development and progression of multiple human malignancies. However, little known about its functional role molecular mechanism MM. The aim this study was investigate clinical biological significance CCAT1 Our data showed that relative expression levels were significantly upregulated MM tissues...
Summary Soybean staygreen syndrome, characterized by delayed leaf and stem senescence, abnormal pods, aborted seeds, has recently become a serious prominent problem in soybean production. Although the pest Riptortus pedestris received increasing attention as possible cause of mechanism remains unknown. Here, we clarify that direct feeding R. , not transmission pathogen this pest, is primary typical syndrome critical damage occurs at early pod stage . Transcriptome profiling indicated many...
Abstract Spatial transcriptomics unveils the complex dynamics of cell regulation and transcriptomes, but it is typically cost-prohibitive. Predicting spatial gene expression from histological images via artificial intelligence offers a more affordable option, yet existing methods fall short in extracting deep-level information pathological images. In this paper, we present THItoGene, hybrid neural network that utilizes dynamic convolutional capsule networks to adaptively sense potential...
Abstract The Nucleic Acid Knowledgebase (nakb.org) is a new data resource, updated weekly, for experimentally determined 3D structures containing DNA and/or RNA nucleic acid polymers and their biological assemblies. NAKB indexes acid-containing derived from all major structure determination methods (X-ray, NMR EM), including held by the Protein Data Bank (PDB). As planned successor to Database (NDB), NAKB’s design preserves functionality of NDB provides novel acid-centric content, structural...
Abstract Introduction Self‐repair of spinal cord injury (SCI) has been found in humans and experimental animals with partial recovery neurological functions. However, the regulatory mechanisms underlying spontaneous locomotion after SCI are elusive. Aims This study was aimed at evaluating pathological changes injured exploring possible mechanism related to recovery. Results Immunofluorescence staining performed detect GAP43 expression lesion site transection (SCT) rats. Then RNA sequencing...
Motivation: Recent studies reveal an important role of non-coding circular RNA (circRNA) in the control cellular processes. Because differences organization plant and mammal genomes, sensitivity accuracy circRNA prediction programs using algorithms developed for animals humans perform poorly plants. Results: A software plants (termed PcircRNA_finder) was that is more sensitive detecting circRNAs than other frequently used (such as find_circ CIRCexplorer), Based on analysis simulated real...
Day length has an important influence on flowering and growth habit in many plant species. In crops such as soybean, photoperiod sensitivity determines the geographical range over which a given cultivar can grow flower. The soybean genome contains ~10 genes homologous to FT, central regulator of from Arabidopsis thaliana. However, precise roles these FTs are not clearly. Here we show that one gene, GmFT2b, promotes under long-days (LDs). Overexpression GmFT2b upregulates expression...
PIWIL2, a member of PIWI/AGO gene family, is expressed in the germline stem cells (GSCs) testis for gametogenesis but not adult somatic and cells. It has been implicated to play an important role tumor development. We have previously reported that precancerous (pCSCs) constitutively express Piwil2 transcripts promote their proliferation. Here we show these de facto represent Piwil2-like (PL2L) proteins. identified several PL2L proteins including PL2L80, PL2L60, PL2L50 PL2L40, using combined...
The genus Echinochloa (Poaceae) includes numerous problematic weeds that cause the reduction of crop yield worldwide. To date, DNA sequence information is still limited in Echinochloa. In this study, we completed entire chloroplast genomes two species (Echinochloa oryzicola and crus-galli) based on high-throughput sequencing data from their fresh green leaves. are 139,891 139,800 base pairs length, respectively, contain 131 protein-coding genes, 79 indels 466 substitutions helpful for...
Circular RNAs (circRNAs) have recently been shown to exert effects on multiple pathological processes by acting as miRNA sponges. However, the roles of circRNAs in ovarian senescence are largely unknown. The objective this study was identify involved aging and predict their potential biological functions. We first performed RNA-sequencing generate circRNA expression profiles from young (n = 3) groups. In total, 48,220 were identified, which 194 significantly up-regulated 207 down-regulated...