A5041579823- Robotic Mechanisms and Dynamics
- Iterative Learning Control Systems
- Soft Robotics and Applications
- Cancer Genomics and Diagnostics
- Piezoelectric Actuators and Control
- Prenatal Screening and Diagnostics
- Cancer-related molecular mechanisms research
- Robot Manipulation and Learning
- Manufacturing Process and Optimization
- Gastric Cancer Management and Outcomes
- Advanced Surface Polishing Techniques
- Gastroesophageal reflux and treatments
- MicroRNA in disease regulation
- Diamond and Carbon-based Materials Research
- Landfill Environmental Impact Studies
- Epigenetics and DNA Methylation
- Infection Control and Ventilation
- Advanced Measurement and Metrology Techniques
- Esophageal Cancer Research and Treatment
- Genomics and Phylogenetic Studies
- Metal and Thin Film Mechanics
- Nonlinear Photonic Systems
- Nonlinear Waves and Solitons
- Coagulation and Flocculation Studies
- Pancreatic and Hepatic Oncology Research
BGI Group (China)
2021-2025
Shandong University of Science and Technology
2021-2025
Hebei Medical University
2018-2024
Second Hospital of Hebei Medical University
2018-2024
Southwest University
2021-2024
Chinese University of Hong Kong
2018-2024
BGI Research
2023-2024
Hebei University of Chinese Medicine
2024
Hospital of Hebei Province
2024
Ningbo University
2016-2024
Barnyardgrass (Echinochloa crus-galli) is a pernicious weed in agricultural fields worldwide. The molecular mechanisms underlying its success the absence of human intervention are presently unknown. Here we report draft genome sequence hexaploid species E. crus-galli, i.e., 1.27 Gb assembly representing 90.7% predicted size. An extremely large repertoire genes encoding cytochrome P450 monooxygenases and glutathione S-transferases associated with detoxification found. Two gene clusters...
Significance We identified differentiating molecular characteristics of plasma EBV DNA between nasopharyngeal carcinoma (NPC) patients and non-NPC subjects. Sequencing-based analysis revealed higher amounts generally longer fragment lengths viral molecules in NPC than Based on these findings, we have developed a highly accurate blood-based test for screening NPC. Such an approach is shown to enhance the positive predictive value demonstrate superior performance screening. It also obviates...
Significance Cell-free DNA molecules in the plasma of pregnant women exhibit nonrandom fragmentation with preferred end sites. We studied if such sites might bear any relationship fragment lengths DNA. Short and long were associated different Analysis size-tagged ends could be used for measuring fetal fraction facilitating trisomy 21 detection. Fetal generally located nucleosome cores, while maternal ones linker regions. This conceptual framework provides an explanation relative shortness...
Safe and efficient provision of electrical stimulation (ES) for nerve repair regeneration is a problem that needs to be addressed. In this study, silk fibroin/poly(vinylidene fluoride-co-hexafluoropropylene)/Ti3C2Tx (SF/PVDF-HFP/MXene) composite scaffold with piezoelectricity was developed by electrospinning technology. MXene loaded the enhance piezoelectric properties (Output voltage reaches up 100 mV), mechanical properties, antibacterial activity. Cell experiments demonstrated under...
Abstract Epstein-Barr virus (EBV) is associated with a number of diseases, including malignancies. Currently, it not known whether patients different EBV-associated diseases have methylation profiles circulating EBV DNA. Through whole-genome analysis plasma samples from nasopharyngeal carcinoma (NPC), lymphoma and infectious mononucleosis, we demonstrate that DNA exhibit disease-associated pattern. This observation implies significant potential for the development NPC diagnostics. We further...
The genus Echinochloa (Poaceae) includes numerous problematic weeds that cause the reduction of crop yield worldwide. To date, DNA sequence information is still limited in Echinochloa. In this study, we completed entire chloroplast genomes two species (Echinochloa oryzicola and crus-galli) based on high-throughput sequencing data from their fresh green leaves. are 139,891 139,800 base pairs length, respectively, contain 131 protein-coding genes, 79 indels 466 substitutions helpful for...
Oxidative stress is an important contributory factor resulting the development of kidney injury in patients with diabetes. Numerous vitro and vivo studies have suggested that anthocyanins, natural phenols commonly existing numerous fruits vegetables, exhibit antioxidative, anti‑inflammatory antihyperlipidemic effects; however, their effects underlying mechanisms on diabetic nephropathy (DN) not yet been fully determined. In present study, regulation apoptosis metabolism antioxidative...
Kinematic accuracy reliability is an important performance index in the evaluation of mechanism quality. By using a 3-DOF 3-PUU parallel robot manipulator as research object, position and orientation error model was derived by mapping relation between input output mechanism. Three sensitivity indexes that evaluate kinematic were obtained adapting singular value decomposition translation matrix. Considering influence controllable uncontrollable factors on accuracy, mathematical based random...
Sesquizygotic multiple pregnancy is an exceptional intermediate between monozygotic and dizygotic twinning. We report a monochorionic twin with fetal sex discordance. Genotyping of amniotic fluid from each sac showed that the twins were maternally identical but chimerically shared 78% their paternal genome, which makes them genetically in dizygotic; they are sesquizygotic. observed no evidence sesquizygosis 968 pairs whom we screened by means pangenome single-nucleotide polymorphism...
Long non-coding RNAs (lncRNAs) are crucial in contributing to gastric tumorigenesis and development. However, the diagnostic value of majority lncRNAs cancer (GC) not clear. The present study investigated associated transcript 2 (GACAT2), a lncRNA that is aberrantly expressed GC tissues. A total 343 plasma samples from 80 healthy individuals, 29 patients with dysplasia (GD) 117 paired preoperative postoperative were collected. Plasma GACAT2 levels subsequently measured by reverse...
Cellular mitochondrial DNA (mtDNA) is organized as circular, covalently closed and double-stranded DNA. Studies have demonstrated the presence of short mtDNA fragments in plasma. It not known whether circular might concurrently exist with linear plasma.We elucidated topology plasma using restriction enzyme BfaI cleavage signatures on fragment ends to differentiate mtDNA. both carrying were defined circular-derived mtDNA, whereas those no signature or 1 linear-derived An independent assay...
The morphological structure reconstruction and functional recovery of long-distance peripheral nerve injury (PNI) are global medical challenges. Biodegradable scaffolds that provide mechanical support for the growth extension neurites a desired way to repair PNI. However, synchrony scaffold degradation regeneration is still challenging. Here, novel bioinspired multichannel guide conduit (MNGC) with topographical cues based on silk fibroin ε-polylysine modification was constructed. This...
Circulating cell-free RNA (cfRNA) has emerged as a promising analyte for disease detection. However, the comprehensive profiling of diverse cfRNA types remains under-characterized. Here, we applied new wide-spectrum sequencing method and simultaneously captured rRNA, tRNA, mRNA, miRNA, lncRNA, all mitochondrial RNA. The compositions, size distributions, highly abundant genes were analyzed each type cfRNA. We depicted cell origin profiles 66 generally healthy individuals found that BMI showed...
There are limited parallel robots applicable to three-axis grinding machines due the restricted reachable workspace originating from multiple kinematic chains with spatial joints. The robot will gain significant potential in industry if a larger can be achieved. This research introduces special relationship between upper triangular matrix and structures for purpose of designing group novel without detailed inverse solution selected manipulator is derived accordance its straightforward...
The incidence of colorectal cancer (CRC) is rapidly increasing, and early detection plays a crucial role in improving the prognosis survival rates patients. This study aimed to assess diagnostic ability combined SDC2-KCNQ5-IKZF1 methylation levels plasma for CRC detection. A total 92 patients were recruited from Department General Surgery at Second Hospital Hebei Medical University, including 56 patients, 22 polyp adenoma 14 healthy controls. Plasma cfDNA was extracted test SDC2, KCNQ5,...
Spring viraemia of carp virus (SVCV) is the causative pathogen outbreaks an acute haemorrhagic and contagious responsible for significant mortality in several cyprinid species. However, endocytic pathway(s) their regulatory molecules have not been characterized SVCV. Here, using a combination specific pharmacological inhibitors, transmission electron microscopy, immunofluorescence microscopy real-time quantitative PCR, we found that SVCV entered grass ovary cells via clathrin-mediated...
This paper presents a novel redundantly actuated 2R P U-2S R parallel manipulator that can be employed to form five-axis hybrid kinematic machine tool for large heterogeneous complex structural component machining in aerospace field. On the contrary series manipulators, has potential merits of high stiffness, speed, excellent dynamic performance, and complicated surface processing capability. First, by resorting screw theory, degree freedom proposed is briefly addressed with general...