A5067605184- RNA modifications and cancer
- Inflammasome and immune disorders
- MicroRNA in disease regulation
- Cancer-related Molecular Pathways
- Head and Neck Cancer Studies
- Cancer Immunotherapy and Biomarkers
- Heme Oxygenase-1 and Carbon Monoxide
- Ferroptosis and cancer prognosis
- Cancer-related molecular mechanisms research
- RNA Research and Splicing
- Corrosion Behavior and Inhibition
- Colorectal and Anal Carcinomas
- Liver Disease Diagnosis and Treatment
- Inflammatory mediators and NSAID effects
- Hydrogen embrittlement and corrosion behaviors in metals
- Developmental Biology and Gene Regulation
- Pancreatitis Pathology and Treatment
- TGF-β signaling in diseases
- Congenital heart defects research
- Muscle and Compartmental Disorders
- Cancer, Lipids, and Metabolism
- NF-κB Signaling Pathways
- Gastroesophageal reflux and treatments
- Immune Cell Function and Interaction
- Circular RNAs in diseases
Air Force Medical University
2025
Central South University
2025
Anhui Medical University
2008-2024
First Affiliated Hospital of Anhui Medical University
2008-2024
Zhongshan Hospital
2024
Fudan University
2021-2024
Peking University Cancer Hospital
2023-2024
Peking University
2023-2024
Sun Yat-sen University
2024
China Pharmaceutical University
2023
Erythrocyte formation occurs throughout life in response to cytokine signaling. We show that microRNA-451 (miR-451) regulates erythropoiesis vivo. Mice lacking miR-451 display a reduction hematrocrit, an erythroid differentiation defect, and ineffective oxidative stress. 14-3-3zeta, intracellular regulator of signaling is repressed by miR-451, up-regulated miR-451(-/-) erythroblasts, inhibition 14-3-3zeta rescues their defect. These findings reveal essential role as mediator the proerythroid...
Pitx2 is the homeobox gene located in proximity to human 4q25 familial atrial fibrillation (AF) locus. When deleted mouse germline, haploinsufficiency predisposes pacing-induced AF, indicating that reduced promotes an arrhythmogenic substrate. Previous work focused on developmental functions predispose AF. Although expressed postnatal left atrium, it unknown whether has distinct and functions.To investigate function, we conditionally inactivated atrium while leaving its function intact....
The molecular mechanisms underlying atrial fibrillation, the most common sustained cardiac arrhythmia, remain poorly understood. Genome-wide association studies uncovered a major fibrillation susceptibility locus on human chromosome 4q25 in close proximity to paired-like homeodomain transcription factor 2 (Pitx2) homeobox gene. Pitx2, target of left-sided Nodal signaling pathway that initiates early development, represses sinoatrial node program and pacemaker activity left side. To address...
The hypothalamic-pituitary (HP) unit can produce various hormones to regulate immune responses, and some of its downstream or effectors are elevated in cancer patients. We show that the HP promote myelopoiesis immunosuppression accelerate tumor growth. Subcutaneous implantation tumors induced hypothalamus activation pituitary α-melanocyte-stimulating hormone (α-MSH) production mice. α-MSH acted on bone marrow progenitors myelopoiesis, myeloid cell accumulation, immunosuppression, growth...
Abstract Objective Osteonecrosis of the femoral head (ONFH) is a severe disease that primarily affects middle-aged population, imposing significant economic and social burden. Recent research has linked progression non-traumatic osteonecrosis (NONFH) to composition gut microbiota. Steroids alcohol are considered major contributing factors. However, relationship between NONFH caused by two etiologies microbiota remains unclear. In this study, we examined fecal metabolic phenotypes groups...
Faithful transcription of DNA is constantly threatened by different endogenous and environmental genotoxic effects. Transcription coupled repair (TCR) has been described to stop quickly remove lesions from the transcribed strand active genes, permitting rapid resumption blocked transcription. This mechanism well characterized in past using individual target genes. Moreover, numerous efforts investigated fate RNA polymerase II (Pol II) during mechanisms suggested that stopped Pol complexes...
Early heart development in Drosophila and vertebrates involves the specification of cardiac precursor cells within paired progenitor fields, followed by their movement into a linear tube structure. The latter process requires coordinated cell interactions, migration, differentiation as primitive develops toward status functional organ. In embryo, cardioblasts emerge from bilateral dorsal mesoderm primordia, alignment rows that meet at midline morph vessel. Genes function coordinating...
Dorsal vessel morphogenesis in Drosophila melanogaster serves as a superb system with which to study the cellular and genetic bases of heart tube formation. We used cardioblast-expressed Toll-GFP transgene screen for additional genes involved development identified tailup locus essential normal dorsal tailup, related vertebrate islet1, encodes LIM homeodomain transcription factor expressed all cardioblasts pericardial cells well associated lymph gland hematopoietic organs alary muscles that...
Neoadjuvant immunotherapy with anti-PD-1 was proved promising in resectable non-small cell lung cancer (NSCLC). Immune-related adverse events (irAEs) have been preliminarily implicated their association treatment efficacy. Here we elucidated the early onset of irAEs associated better clinical outcomes a prospective study (Renaissance study).We conducted NSCLC patients treated by neoadjuvant Toripalimab (240mg, every 3 weeks) plus double platinum-based chemotherapy from December 2020 to March...
Nuclear retinoic acid (RA) receptors (RARα, β and γ) are ligand-dependent transcription factors that regulate the expression of a battery genes involved in cell differentiation proliferation. They also phosphoproteins we previously showed importance their phosphorylation transcriptional activity. In study reported here, conducted genome-wide analysis regulated by RARs mouse embryonic fibroblasts (MEFs) comparing wild-type MEFs to lacking three RARs. We found absence RA, control several gene...
Backgrounds/Aims: The selective κ-opioid agonist U50,488H protects heart from myocardial ischemia-reperfusion (MI/R) injury. We examined whether is also beneficial for MI/R induced failure. Methods: Anesthetized male Sprague-Dawley rats were subjected to 30 min of ischemia via left anterior descending coronary artery (LAD) occlusion, followed by 4 weeks reperfusion. Infarct size was Evans blue/triphenyl tetrazolium chloride (TTC) staining. Cardiac function and remodeling echocardiography...