A5100756474- Hematopoietic Stem Cell Transplantation
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Cytomegalovirus and herpesvirus research
- Immune cells in cancer
- Mesenchymal stem cell research
- Immune Response and Inflammation
- Heme Oxygenase-1 and Carbon Monoxide
- Peroxisome Proliferator-Activated Receptors
- Chronic Myeloid Leukemia Treatments
- Liver Disease Diagnosis and Treatment
- Immunotherapy and Immune Responses
- Extracellular vesicles in disease
- CAR-T cell therapy research
- Circular RNAs in diseases
- Inflammatory mediators and NSAID effects
- Inflammasome and immune disorders
- Acute Myeloid Leukemia Research
- Hepatitis B Virus Studies
- Monoclonal and Polyclonal Antibodies Research
- Chemical Reactions and Isotopes
- Autophagy in Disease and Therapy
- MicroRNA in disease regulation
- Blood groups and transfusion
- Chemokine receptors and signaling
Peking University
2010-2025
Beijing Normal University
2025
University of Chinese Academy of Sciences
2024
China University of Petroleum, East China
2023-2024
Harbin Medical University
2020-2024
Peking University People's Hospital
2010-2024
Second Affiliated Hospital of Harbin Medical University
2020-2024
Air Force General Hospital PLA
2009-2024
Dalian University of Technology
2024
Beijing University of Chemical Technology
2014-2024
Circular RNAs (circRNAs) and extracellular vesicles (EVs) are involved in various malignancies. We aimed to clarify the functions mechanisms of dysregulated circRNAs cells EVs cholangiocarcinoma (CCA).CircRNA microarray was used identify circRNA expression profiles CCA tissues bile-derived (BEVs). CCA-associated 1 (circ-CCAC1) measured by quantitative real-time PCR. The clinical importance circ-CCAC1 analyzed receiver operating characteristic curves, Fisher's exact test, Kaplan-Meier plots,...
Abstract Arsenic exposure causes nonalcoholic steatohepatitis (NASH). Inflammation is a key contributor to the pathology of fatty liver disease (NAFLD), including NASH. However, it unclear how arsenic induces inflammation. In mouse livers, we show that trioxide (As 2 O 3 ) induced NASH, increased autophagy and NLRP3 inflammasome activation, lipid accumulation, resulted in dysregulation lipid-related genes. Supplemented with taurine (Tau) attenuated inflammation caused by As . HepG2 cells,...
This review summarizes the research progress of single-atom catalysts (SACs) in hydrogen production and hydrogenation, proposes rational design principles SACs for hydrogenation firstly.
AIM: The aim of this study was to observe the possible change microRNAs (miRNAs) in serum extracellular vesicles (EVs) from hepatocellular carcinoma (HCC) patients. METHODS: were purified seventeen healthy donors, sixteen chronic hepatitis B (CHB) patients and twenty-four HCC sequenced analyzed obtain highly differentially expressed genes (DEGs). Finally, expression pattern DEGs validated using qRT-PCR. RESULTS: We found that hsa-miR-21-5p hsa-miR-144-3p significantly higher liver cancer...
Myeloid-derived suppressor cells (MDSCs) are proposed to control graft-versus-host disease (GVHD) in allogeneic hematopoietic stem cell transplantation (allo-HSCT). However, the definition of human MDSCs has not yet reached consensus, and mechanism GVHD remains unclear. Immature myeloid (HLA-DR−/lowCD33+CD16−) were tested before after granulocyte colony-stimulating factor (G-CSF) administration healthy donor isolated for suppression assays co-culture with T vitro. Isolated infused humanized...
Hydroformylation of olefins, as a study olefinic downstream derivative production, is great relevance in chemical production. Heterogeneous hydroformylation beneficial for catalyst separation and recycling compared to homogeneous systems. Cobalt cheap metal with excellent catalytic activity well the precious rhodium. Therefore, research on cobalt-based catalysts heterogeneous has value significance. The nano or atomic structures have significant impact behaviors process. There rarely design...
Floral fragrance is one of the most important characteristics ornamental plants and plays a pivotal role in plant lifespan such as pollinator attraction, pest repelling, protection against abiotic biotic stresses. However, precise determination floral limited. In present study, volatile compounds six Hedychium accessions exhibiting from faint to highly fragrant were comparatively analyzed via gas chromatography–mass spectrometry (GC–MS) Electronic nose (E-nose). A total 42 identified through...
Distant metastasis is a prevalent cause of mortality in gastric cancer (GC) patients. Anoikis, process that induces cell death when cells get detached from the extracellular matrix (ECM), acts as barrier to tumor metastasis. To survive circulatory system and metastasize, must acquire anoikis resistance. It crucial identify molecular processes resistance GC since this might lead discovery novel treatment targets improve long-term survival In study, we employed quantitative proteomics growth...
Background: Recombinant subunit vaccines leveraging pathogen-derived components are pivotal for disease prevention. Nonetheless, application of these still faces challenges such as low immunogenicity and a short half-life. Additionally, selecting appropriate antigens presents significant barrier in recombinant vaccine design. Methods: Here, we applied novel approach to address by developing targeting LMP2A. We employed silico epitope prediction splicing create enrichment regions (EERs)...
Abstract Electrocatalysis is fundamental to modern energy conversion, driving essential processes like water splitting, CO 2 reduction, nitrogen fixation, and biomass transformation. These reactions are pivotal for advancing sustainable solutions, enabling clean hydrogen production, efficient carbon recycling, valueadded chemical synthesis. However, most studies currently struggle achieve the industrially‐relevant current densities (>300 mA cm −2 ), alongside challenges in maintaining...
Angiotensin II (Ang II) has been shown to function as a key role in neovascularization of hepatocellular carcinoma (HCC), but little is known its underlying mechanisms. The aim this study was explore the Janus kinase/signal transducer and activator transcription (JAK/STAT) signaling pathway Ang II-induced HCC angiogenic factors production. Herein, we found that upregulated production such vascular endothelial growth factor (VEGF), angiopoietin-2 (Ang-2) Tie-2 MHCC97H cells time-...
Metastasis is the major cause of cancer-related deaths. Targeting process metastasis has been proposed as a strategy to fight cancer. Scutellaria barbata D. Don (S. barbata), traditional Chinese medicine, used for treatment many diseases, including This study aimed determine anti-metastatic effect total flavonoids S. (TF-SB) using human hepatocarcinoma MHCC97H cell line with high metastatic potential. Our results show that TF-SB could significantly inhibit proliferation and invasion cells in...
AIM:To investigate the effects of Chrysanthemum indicum extract (CIE) on inhibition proliferation and apoptosis, underlying mechanisms, in a human hepatocellular carcinoma (HCC) MHCC97H cell line. METHODS:Viable rat hepatocytes endothelial ECV304 cells were examined by trypan blue exclusion MTT assay, respectively, as normal controls.The was determined assay.The cellular morphology observed phase contrast microscopy.Flow cytometry performed to analyze apoptosis with annexin V/propidium...
Erythroid differentiation-associated gene (EDAG) has been considered to be a transcriptional regulator that controls hematopoietic cell differentiation, proliferation, and apoptosis. The role of EDAG in erythroid differentiation primary progenitor cells vivo remains unknown. In this study, we found is highly expressed CMPs MEPs upregulated during the CD34(+) following erythropoietin (EPO) treatment. Overexpression induced vitro using immunodeficient mice. Conversely, knockdown reduced...