A5068134036- Urinary Bladder and Prostate Research
- MicroRNA in disease regulation
- Glaucoma and retinal disorders
- Urinary Tract Infections Management
- Pelvic floor disorders treatments
- Retinal Diseases and Treatments
- Circular RNAs in diseases
- Extracellular vesicles in disease
- Inflammatory Bowel Disease
- Minimally Invasive Surgical Techniques
- Hernia repair and management
- RNA modifications and cancer
- Gastrointestinal Tumor Research and Treatment
- Cancer, Hypoxia, and Metabolism
- Epigenetics and DNA Methylation
- Cancer-related molecular mechanisms research
- Ophthalmology and Visual Impairment Studies
- Intestinal and Peritoneal Adhesions
- Gut microbiota and health
- Cardiac, Anesthesia and Surgical Outcomes
- Nanoplatforms for cancer theranostics
- ATP Synthase and ATPases Research
- Immunotherapy and Immune Responses
- Enhanced Recovery After Surgery
- Colorectal Cancer Surgical Treatments
Shanghai Jiao Tong University
2011-2025
Shanghai Sixth People's Hospital
2024-2025
Xinyang Normal University
2025
Union Hospital
2022-2024
Huazhong University of Science and Technology
2020-2024
Shanghai Ninth People's Hospital
2016-2024
Shanghai Pudong New Area Gongli Hospital
2022-2024
Second Military Medical University
2022-2024
Nanjing Institute of Technology
2024
Kunming University of Science and Technology
2024
Objective: To analyze the epidemiological history, clinical manifestations, treatment and short-term prognosis of 31 cases 2019 novel coronavirus (2019-nCoV) infection in children from six provinces (autonomous region) northern China. Methods: A retrospective analysis symptoms, signs, laboratory examinations, chest imaging, 2019-nCoV was conducted. The patients were diagnosed between January 25th, 2020 February 21st, 21 hospitals 17 cities Shaanxi, Gansu, Ningxia, Hebei, Henan Shandong....
Erianin, a natural product derived from Dendrobium chrysotoxum, has exhibited potential antitumor activity in various malignancies, including hepatocarcinoma, melanoma, and promyelocytic leukemia. Here we explored the effects of erianin on osteosarcoma (OS) vitro vivo further elucidated underlying molecule mechanisms. In this study, found that potently suppressed cell viability OS lines. Treatment with induced G2/M-phase arrest, apoptosis, autophagy cells. Further studies showed...
Abstract Malignant ascites in advanced hepatocellular carcinoma (HCC) is a complex clinical problem that lacks effective treatments. Due to the insensitivity of HCC cells traditional chemotherapies, low drug accumulation, and limited residence time peritoneal cavity, therapeutic effects malignant are not satisfactory. In this study, an injectable hydrogel delivery system based on chitosan hydrochloride oxidized dextran (CH‐OD) designed load sulfasalazine (SSZ), FDA‐approved with...
OBJECTIVE To examine the impact of each type urinary incontinence (stress, urge, and mixed) on health‐related quality life (HRQL). SUBJECTS AND METHODS The USA National Overactive Bladder Evaluation (NOBLE) programme prevalence was used to identify respondents with based upon telephone survey responses. A nested case‐control study then conducted symptoms an overactive bladder (OAB), age gender‐matched controls; this consisted completing a series questionnaires, including OAB‐q (an HRQL scale...
To evaluate the prevalence of nocturia and its effects, with without concomitant overactive bladder (OAB, i.e. urgency, frequency, urge incontinence nocturia), on health-related quality life (HRQoL) sleep.A national survey was conducted in USA to assess OAB nocturia. A nested case-control study among respondents symptoms age- gender-matched controls, participants completing a series questionnaires HRQoL (OAB-q, Short Form-36, Medical Outcomes Study (MOS) sleep scale). Descriptive analyses,...
We here evaluated the potential anti-colorectal cancer activity by erastin, a voltage-dependent anion channel (VDAC)-binding compound. Our in vitro studies showed that erastin exerted potent cytotoxic effects against multiple human colorectal cell lines, possibly via inducing oxidative stress and caspase-9 dependent apoptosis. Further, mitochondrial permeability transition pore (mPTP) opening was observed erastin-treated cells, which evidenced VDAC-1 cyclophilin-D (Cyp-D) association,...
Abstract Cisplatin-based chemotherapy improves the control of distant metastases in patients with nasopharyngeal carcinoma (NPC); however, around 30% fail treatment due to acquired drug resistance. Epigenetic regulation is known contribute cisplatin resistance; nevertheless, underlying mechanisms remain poorly understood. Here, we showed that lysine-specific demethylase 5B (KDM5B) was overexpressed and correlates tumor progression resistance NPC. We also specific inhibition KDM5B impaired...
Abstract Background The development of radioresistance seriously hinders the efficacy radiotherapy in lung cancer. However, underlying mechanisms by which occurs are still incompletely understood. N 6 -Methyladenosine (m A) modification RNA is involved cancer progression, but its role remains elusive. This study aimed to identify m A regulators radiosensitivity and further explore therapeutic targets overcome radioresistance. Methods Bioinformatic mining was used regulator IGF2BP2...
Abstract Background Glioblastoma (GBM) is the most common malignant tumor of central nervous system. It an aggressive characterized by rapid proliferation, diffuse morphology, and poor prognosis. Unfortunately, current treatments, such as surgery, radiotherapy, chemotherapy, are unable to achieve good outcomes. Therefore, there urgent need explore new treatment targets. A detailed mechanistic exploration role nuclear pore transporter KPNB1 in GBM lacking. This study demonstrated that...
Abstract Myofibroblast buildup and prostatic fibrosis play a crucial role in the development of benign hyperplasia (BPH). Treatments specifically targeting myofibroblasts could be promising approach for treating BPH. Tadalafil, phosphodiesterase type 5 (PDE5) inhibitor, holds potential to intervene this biological process. This study employs stromal fibroblasts induce myofibroblast differentiation through TGFβ1 stimulation. As result, tadalafil significantly inhibited fibroblast...
AIM: The aim of this study was to observe the possible change microRNAs (miRNAs) in serum extracellular vesicles (EVs) from hepatocellular carcinoma (HCC) patients. METHODS: were purified seventeen healthy donors, sixteen chronic hepatitis B (CHB) patients and twenty-four HCC sequenced analyzed obtain highly differentially expressed genes (DEGs). Finally, expression pattern DEGs validated using qRT-PCR. RESULTS: We found that hsa-miR-21-5p hsa-miR-144-3p significantly higher liver cancer...
The relationship between traditional village landscape genes and the geographical environment is closely intertwined, exhibiting notable spatial differences cultural characteristics during scale transformations. To effectively elucidate formation mechanisms of these genes, it essential to construct a multi-scale analytical framework that integrates multiple dimensions. This paper address challenges by expanding sample selection range combining both qualitative quantitative analyses across...
To evaluate the effect of factors on space between posterior capsule and IOL. A total 126 patients were included in study. All underwent AS-OCT examinations after surgery. The relationship capsule-IOL (PC-IOL) adhesion range various factors, including IOL type, follow-up period, axial length, lens thickness, analyzed. When period was shorter than 1 week, proportion PC-IOL greater 1/2 ZA9003, softec, SN6ATX, 525 groups 66.7%, 78.9%, 25%, 53.8%, respectively. longer month, these proportions...
Background: Our previous studies have demonstrated that human papillomaviruse (HPV)-16 oncoproteins promoted epithelial-mesenchymal transition (EMT), leading to non-small cell lung cancer (NSCLC) progression, but the underlying molecular mechanisms still remain unclear. PI3K/Akt/HIF-1α signaling pathway has been reported mediate hypoxia-induced EMT. In this study, we further explored role of in HPV-16 oncoprotein-induced EMT NSCLC cells. Methods: A549 and NCI-H460 cells were transiently...
Objective Increasing evidence suggests that gut microbiota is involved in the occurrence and progression of urinary system diseases such as clear cell renal carcinoma (ccRCC). However, mechanism how alteration metagenome promotes ccRCC remains unclear. Here we aim to elucidate association specific bacteria their metabolites with ccRCC. Methods In a pilot case-control study among 30 patients (RCC group) healthy controls (Control group), 16S ribosomal RNA (rRNA) gene sequencing were analyzed...
Betulin is a common triterpene that can be readily obtained from various plants, particularly birch trees, in their natural environment. Specific tumor cells are sensitive to betulin, whereas healthy not. was observed stimulate programmed cell death of cancer lines; however, the precise molecular mechanism action betulin remains unknown. The present study used colon cells, which mass apoptosis triggered by identified, and apoptotic process demonstrated occur via activation caspase‑3 ‑9...
Our previous studies have found that human papillomavirus (HPV)-16 E7 oncoprotein promotes epithelial-mesenchymal transition (EMT) and hypoxia-inducible factor-1α (HIF-1α) protein accumulation in non-small cell lung cancer (NSCLC) cells monoamine oxidase A (MAOA) is highly expressed NSCLC tissues. Here, we further explored the role of MAOA HPV-16 E7-induced EMT HIF-1α A549 NCI-H460 cells. results showed enhanced expression Additionally, knockout inhibited migration, invasion, EMT,...
This study explored the effects of miR-125-5p and interleukin-6 receptor (IL-6 R) on ulcerative colitis (UC) cell models mouse models. The sera derived from UC patients healthy subjects were collected for expression analysis. in vitro vivo model constructed used. Expressions miR-125-5p, IL-6 R, AK1/STAT3 NF-κB pathways, inflammatory factors, histopathology apoptosis determined by conducting a series molecular experiments. relationship between R was analyzed TargetScan7.2 verified...
In Brief Purpose: To determine whether comorbidities are more prevalent among individuals with neovascular age-related macular degeneration (NV-AMD) than without AMD. Methods: This 2-year, retrospective, case-control study included Medicare beneficiaries (standard 5% analytic sample) continuously enrolled from January 1, 2003, to December 31, 2004, excluding those in managed care plans. The NV-AMD cohort ≥65 at baseline a diagnosis of 2003 and 2004. Age-, gender-, race-matched controls were...
To determine utilisation patterns and calculate treatment failure discontinuation rates in patients with open angle glaucoma treated the United Kingdom any of six groups intraocular pressure (IOP) lowering agents.The UK General Practice Research Database was used to identify newly diagnosed (after 1 January 1997) who were naive therapy index drug groups: carbonic anhydrase inhibitors, latanoprost, miotics, sympathomimetics, timolol, other (non-timolol) beta blockers. Analyses included data...