A5002690169- AI in cancer detection
- Nanoplatforms for cancer theranostics
- Neuroscience and Neuropharmacology Research
- Immunotherapy and Immune Responses
- High Entropy Alloys Studies
- Cancer Immunotherapy and Biomarkers
- Extracellular vesicles in disease
- High-Temperature Coating Behaviors
- Surface Treatment and Residual Stress
- Erosion and Abrasive Machining
- Immune cells in cancer
- Additive Manufacturing Materials and Processes
- Advanced machining processes and optimization
- MicroRNA in disease regulation
- Advanced Machining and Optimization Techniques
- High-Velocity Impact and Material Behavior
- Memory and Neural Mechanisms
- Cancer-related molecular mechanisms research
- Corneal Surgery and Treatments
- Epigenetics and DNA Methylation
- Advanced Surface Polishing Techniques
- Ubiquitin and proteasome pathways
- Organ Transplantation Techniques and Outcomes
- Intermetallics and Advanced Alloy Properties
- nanoparticles nucleation surface interactions
Union Hospital
2019-2025
Huazhong University of Science and Technology
2016-2025
Nanjing University
2021-2024
Guangdong Ocean University
2023-2024
Nanjing University of Chinese Medicine
2024
Sun Yat-sen University
2024
Sun Yat-sen University Cancer Center
2024
Dana-Farber Cancer Institute
2024
Harvard University
2024
Hefei University of Technology
2023
By mimicking the RIBE machinery, we provided an indirect radiotherapy approach based on RT-MP for eradication of MPE in mice.
Background: Tumor associated macrophages (TAMs) have strong plasticity and if reprogrammed, can clear tumor cells regulate the adaptive immune system for cancer immunotherapy. Deubiquitinating enzymes (DUBs), which remove ubiquitin (Ub) from Ub-modified substrates, been with oncogenic metabolism but are not well-known regulating TAMs repolarization. Methods: The expression of DUB related genes in (MΦs) was detected by reverse transcription-PCR. Flow cytometry immunofluorescence were used to...
Photodynamic therapy (PDT) is a clinical cancer treatment modality based on the induction of therapeutic reactive oxygen species (ROS), which can trigger immunogenic cell death (ICD). With aim simultaneously improving both PDT-mediated intracellular ROS production and ICD levels, we designed serum albumin (SA)-coated boehmite ("B"; aluminum hydroxide oxide) organic-inorganic scaffold that could be loaded with chlorin e6 (Ce6), photosensitizer, honey bee venom melittin (MLT) peptide, denoted...
<ns4:p>Fear is a response to impending threat that prepares subject make appropriate defensive responses, whether freeze, fight, or flee safety. The neural circuits underpin how subjects learn about cues signal threat, and have been studied using Pavlovian fear conditioning in laboratory rodents as well humans. These studies established the amygdala key player process led model where learning results from long-term potentiation of inputs convey information conditioned stimulus amygdala. In...
Cancer immunotherapy, which suppresses cancer progression by activating the anti-cancer immunity of patients, shows utility in treating multiple types cancers. Immunogenic cell death (ICD) induced most clinical treatment modalities plays a critical role promoting immunotherapy releasing tumor-associated antigens and neoantigens exposing "danger signals" to stimulate immune cells. This comment article presents different roles nanoparticles various cancers, including chemotherapy,...
Cancer cell radioresistance is the primary cause of decreased curability non–small lung cancer (NSCLC) observed in patients receiving definitive radiotherapy (RT). Following RT, a set microenvironmental stress responses triggered, including senescence. However, senescence often ignored designing effective strategies to resolve radioresistance. Herein, we identify senescence-like characteristics cancer-associated fibroblasts (CAFs) after RT and clarify formidable ability CAFs promoting NSCLC...
Background:The role of senescent cells in the tumor microenvironment (TME) is usually bilateral, and diverse therapeutic approaches, such as radiotherapy chemotherapy, can induce cellular senescence.Cellular interactions are widespread TME, reprogram immune metabolically by producing metabolites.However, how remodel metabolism TME remains unclear.This study aimed to explore precise targets enhance cells-induced anti-tumor immunity from a metabolic perspective. Methods:The vivo senescence...
Abstract Cisplatin-based chemotherapy improves the control of distant metastases in patients with nasopharyngeal carcinoma (NPC); however, around 30% fail treatment due to acquired drug resistance. Epigenetic regulation is known contribute cisplatin resistance; nevertheless, underlying mechanisms remain poorly understood. Here, we showed that lysine-specific demethylase 5B (KDM5B) was overexpressed and correlates tumor progression resistance NPC. We also specific inhibition KDM5B impaired...
Abstract Background The development of radioresistance seriously hinders the efficacy radiotherapy in lung cancer. However, underlying mechanisms by which occurs are still incompletely understood. N 6 -Methyladenosine (m A) modification RNA is involved cancer progression, but its role remains elusive. This study aimed to identify m A regulators radiosensitivity and further explore therapeutic targets overcome radioresistance. Methods Bioinformatic mining was used regulator IGF2BP2...
Abstract Network activity in the lateral central amygdala (CeL) plays a crucial role fear learning and emotional processing. However, local circuits of CeL are not fully understood have only recently begun to be explored detail. Here, we characterized intrinsic using paired whole-call patch-clamp recordings, immunohistochemistry, optogenetics C57BL/6J wild-type somatostatin-cre (SOM-Cre) mice. Our results revealed that throughout rostrocaudal extent CeL, neurons form inhibitory connections...
Abstract Reciprocal interactions between the tumor microenvironment (TME) and cancer cells play important roles in tumorigenesis progression of glioma. Glioma-associated macrophages (GAMs), either peripheral origin or representing brain-intrinsic microglia, are majority population infiltrating immune GAMs, usually classified into M1 M2 phenotypes, have remarkable plasticity regulate through different metabolic pathways. Recently, research efforts increasingly focused on GAMs metabolism as...
Abstract Background Glioblastoma (GBM) is the most common malignant tumor of central nervous system. It an aggressive characterized by rapid proliferation, diffuse morphology, and poor prognosis. Unfortunately, current treatments, such as surgery, radiotherapy, chemotherapy, are unable to achieve good outcomes. Therefore, there urgent need explore new treatment targets. A detailed mechanistic exploration role nuclear pore transporter KPNB1 in GBM lacking. This study demonstrated that...
Abstract Vaccine‐based therapeutics for cancers face several challenges including lack of immunogenicity and tumor escape pathways single antigen targets. It has been reported that radiotherapy an in situ vaccine effect provides antigens following irradiation, helping to activate antigen‐presenting cells (APCs). Herein, a new approach is developed by combining genetically engineered irradiated cell debris (RTD) hyaluronic acid (HA), termed HA@RTD. A cancer line overexpresses...
Radiotherapy (RT) is used for over 50% of cancer patients and can promote adaptive immunity against tumour antigens. However, the underlying mechanisms remain unclear. Here, we discovered that RT induces release irradiated cell-derived microparticles (RT-MPs), which significantly upregulate MHC-I expression on membranes non-irradiated cells, enhancing recognition killing these cells by T cells. Mechanistically, RT-MPs induce DNA double-strand breaks (DSB) in activating ATM/ATR/CHK1-mediated...