A5012518176- Cell Adhesion Molecules Research
- Cancer Diagnosis and Treatment
- Immune Cell Function and Interaction
- Piperaceae Chemical and Biological Studies
- Head and Neck Surgical Oncology
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Proteoglycans and glycosaminoglycans research
- Circular RNAs in diseases
- Head and Neck Cancer Studies
- Cancer Immunotherapy and Biomarkers
- Immunotherapy and Immune Responses
- PI3K/AKT/mTOR signaling in cancer
- Metabolism, Diabetes, and Cancer
- Antimicrobial Peptides and Activities
- Glycosylation and Glycoproteins Research
- Caveolin-1 and cellular processes
- Platelet Disorders and Treatments
- Phytochemical compounds biological activities
Huazhong University of Science and Technology
2021-2024
Union Hospital
2021-2024
Sichuan Cancer Hospital
2024
University of Electronic Science and Technology of China
2024
Southern Medical University
2020-2021
Chinese Academy of Medical Sciences & Peking Union Medical College
2017
Radiotherapy (RT) is used for over 50% of cancer patients and can promote adaptive immunity against tumour antigens. However, the underlying mechanisms remain unclear. Here, we discovered that RT induces release irradiated cell-derived microparticles (RT-MPs), which significantly upregulate MHC-I expression on membranes non-irradiated cells, enhancing recognition killing these cells by T cells. Mechanistically, RT-MPs induce DNA double-strand breaks (DSB) in activating ATM/ATR/CHK1-mediated...
Substantial preclinical evidence has indicated out a direct anti‑proliferation effect of metformin on various solid tumors; however, further and more detailed exploration into its molecular mechanism remains to be performed. The present study aimed investigate the cell viability underlying mechanism, in cultured human skin keratinocyte line, HaCaT. In addition, it clarify role microRNA-21(miR-21)/phosphatase tensin homolog (PTEN)/AKT serine/threonine kinase 1 (Akt) signaling pathway, which...
Patients older than the expected age of local population generally have limited life expectancy. The optimal treatment approach for very elderly patients with head and neck cancer remains uncertain. This study retrospectively analyzed over 78 years old, in 2019 Chinese individuals, who underwent at a tertiary center China. compared overall survival rates among different groups. findings revealed that eligible surgery, radical resection yielded better outcomes to radiotherapy-based...
Abstract Background: Mounting researches have established that long-chain non-coding RNA (lncRNA) and microRNA (miRNA) occupy an essential position in osteosarcoma development. The present study attempted to explicate the functional role mechanism of LINC00485 miR-361-5p regulating progression.Methods: RT-PCR was employed measure expression tissues adjacent healthy tissues. Moreover, correlation between clinicopathological indexes analyzed. Further, low-expressed cell model constructed, CCK8...